2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
- Product Name
- 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
- CAS No.
- 187543-87-9
- Chemical Name
- 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
- Synonyms
- Zavegepant Impurity 56;5,6-Difluoro-o-anisaldehyde;5,6-Difluoro-o-anisaldehyde>2,3-Difluoro-6-methoxybezaldehyde;2,3-DIFLUORO-6-METHOXYBENZALDEHYDE;Benzaldehyde, 2,3-difluoro-6-methoxy-;2,3-Difluoro-6-methoxybenzaldehyde98%;2,3-Difluoro-6-methoxybenzaldehyde 98%;2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%;3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde
- CBNumber
- CB0357506
- Molecular Formula
- C8H6F2O2
- Formula Weight
- 172.13
- MOL File
- 187543-87-9.mol
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Property
- Melting point:
- 55-57
- Boiling point:
- 233.0±35.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C8H6F2O2/c1-12-7-3-2-6(9)8(10)5(7)4-11/h2-4H,1H3
- InChIKey
- AKOJAYHBKACKNJ-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C(OC)C=CC(F)=C1F
- CAS DataBase Reference
- 187543-87-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D3885
- Product name
- 5,6-Difluoro-o-anisaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- D3885
- Product name
- 5,6-Difluoro-o-anisaldehyde
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $412
- Updated
- 2025/07/31
- Product number
- D448715
- Product name
- 2,3-Difluoro-6-methoxybenzaldehyde
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 116756
- Product name
- 2,3-Difluoro-6-methoxybenzaldehyde
- Packaging
- 5g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 2615-3-36
- Product name
- 2,3-Difluoro-6-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 5G
- Price
- $295
- Updated
- 2021/12/16
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Synthesis
68-12-2
115144-40-6
187543-87-9
a) General procedure for the synthesis of 2,3-difluoro-6-methoxybenzaldehyde: A 2 M solution of diisopropylaminolithium THF/n-heptane (171 mL, 341 mmol) was diluted with dry THF (250 mL) under nitrogen protection and cooled to -75°C. A solution of 3,4-difluoroanisole (46.8 g, 325 mmol) in anhydrous THF (100 mL) was added slowly dropwise and stirred for 1 hour keeping the temperature at -75 °C. Subsequently, dry N,N-dimethylformamide (27.6 mL, 358 mmol) was added slowly and stirring was continued at -70 °C for 10 min. After the reaction was completed, acetic acid (30 mL) and water (400 mL) were added and warmed to 10 °C. The reaction mixture was extracted with ether (2 x 300 mL). The organic phases were combined and washed sequentially with water (250 mL), 0.2N aqueous hydrochloric acid (400 mL) and brine (2 x 250 mL), dried with anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure to give a red to orange oil, which was allowed to stand and crystallized. Purification by recrystallization from ether/petroleum ether (40-60 °C) afforded the target product 2,3-difluoro-6-methoxybenzaldehyde (53.0 g, 95% yield).1H NMR (300 MHz, CDCl3) δ: 10.40 (1H, s, CHO), 7.37 (1H, q, ArH), 6.71 (1H, m, ArH), 3.93 ( 3H, s, OCH3).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 21, p. 5395 - 5399
[2] Patent: US2009/118546, 2009, A1. Location in patent: Page/Page column 5-6
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 39 - 40
[4] Patent: US2011/124686, 2011, A1. Location in patent: Page/Page column 45
[5] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00142
2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE manufacturers
- Product
- 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 187543-87-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-29
- Product
- 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 187543-87-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%HPLC
- Supply Ability
- 20 tons
- Release date
- 2022-11-09
- Product
- 5,6-Difluoro-o-anisaldehyde 187543-87-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10