ChemicalBook > CAS DataBase List > 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

Product Name: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
CAS No.: 187543-87-9
Chemical Name: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
Synonyms: Zavegepant Impurity 56;5,6-Difluoro-o-anisaldehyde;5,6-Difluoro-o-anisaldehyde>2,3-Difluoro-6-methoxybezaldehyde;2,3-DIFLUORO-6-METHOXYBENZALDEHYDE;Benzaldehyde, 2,3-difluoro-6-methoxy-;2,3-Difluoro-6-methoxybenzaldehyde98%;2,3-Difluoro-6-methoxybenzaldehyde 98%;2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%;3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde
CBNumber: CB0357506
Molecular Formula: C8H6F2O2
Formula Weight: 172.13
MOL File: 187543-87-9.mol

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2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Property

Melting point:: 55-57
Boiling point:: 233.0±35.0 °C(Predicted)
Density: 1.289±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
color: White to Light yellow to Light orange
Sensitive: Air Sensitive
InChI: InChI=1S/C8H6F2O2/c1-12-7-3-2-6(9)8(10)5(7)4-11/h2-4H,1H3
InChIKey: AKOJAYHBKACKNJ-UHFFFAOYSA-N
SMILES: C(=O)C1=C(OC)C=CC(F)=C1F
CAS DataBase Reference: 187543-87-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37
Hazard Note: Irritant/Air Sensitive
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3885
Product name: 5,6-Difluoro-o-anisaldehyde
Purity: >97.0%(GC)
Packaging: 1g
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: D3885
Product name: 5,6-Difluoro-o-anisaldehyde
Purity: >97.0%(GC)
Packaging: 5g
Price: $412
Updated: 2025/07/31

TRC

Product number: D448715
Product name: 2,3-Difluoro-6-methoxybenzaldehyde
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 116756
Product name: 2,3-Difluoro-6-methoxybenzaldehyde
Packaging: 5g
Price: $185
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2615-3-36
Product name: 2,3-Difluoro-6-methoxybenzaldehyde
Purity: 98%
Packaging: 5G
Price: $295
Updated: 2021/12/16

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2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

68-12-2

115144-40-6

187543-87-9

a) General procedure for the synthesis of 2,3-difluoro-6-methoxybenzaldehyde: A 2 M solution of diisopropylaminolithium THF/n-heptane (171 mL, 341 mmol) was diluted with dry THF (250 mL) under nitrogen protection and cooled to -75°C. A solution of 3,4-difluoroanisole (46.8 g, 325 mmol) in anhydrous THF (100 mL) was added slowly dropwise and stirred for 1 hour keeping the temperature at -75 °C. Subsequently, dry N,N-dimethylformamide (27.6 mL, 358 mmol) was added slowly and stirring was continued at -70 °C for 10 min. After the reaction was completed, acetic acid (30 mL) and water (400 mL) were added and warmed to 10 °C. The reaction mixture was extracted with ether (2 x 300 mL). The organic phases were combined and washed sequentially with water (250 mL), 0.2N aqueous hydrochloric acid (400 mL) and brine (2 x 250 mL), dried with anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure to give a red to orange oil, which was allowed to stand and crystallized. Purification by recrystallization from ether/petroleum ether (40-60 °C) afforded the target product 2,3-difluoro-6-methoxybenzaldehyde (53.0 g, 95% yield).1H NMR (300 MHz, CDCl3) δ: 10.40 (1H, s, CHO), 7.37 (1H, q, ArH), 6.71 (1H, m, ArH), 3.93 ( 3H, s, OCH3).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 21, p. 5395 - 5399
[2] Patent: US2009/118546, 2009, A1. Location in patent: Page/Page column 5-6
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 39 - 40
[4] Patent: US2011/124686, 2011, A1. Location in patent: Page/Page column 45
[5] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00142

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIFLUORO-6-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 187543-87-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-29

SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD

Product: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 187543-87-9
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%HPLC
Supply Ability: 20 tons
Release date: 2022-11-09

Shanghai Rlavie Technology Co ltd

Product: 5,6-Difluoro-o-anisaldehyde 187543-87-9
Price: US $0.00-0.00/kg
Min. Order: 0.0001kg
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-10

187543-87-9, 2,3-DIFLUORO-6-METHOXYBENZALDEHYDERelated Search:

5,6-Difluoro-o-anisaldehyde

2,3-Difluoro-6-methoxybezaldehyde

3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde

2,3-DIFLUORO-6-METHOXYBENZALDEHYDE

2,3-Difluoro-6-methoxybenzaldehyde 98%

2,3-Difluoro-6-methoxybenzaldehyde98%

2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%

5,6-Difluoro-o-anisaldehyde&gt

Benzaldehyde, 2,3-difluoro-6-methoxy-

Zavegepant Impurity 56

187543-87-9

Fluorine series

Benzaldehyde

Aromatic Aldehydes & Derivatives (substituted)