2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
- Product Name
- 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
- CAS No.
- 256417-10-4
- Chemical Name
- 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
- Synonyms
- 5-Fluoroacetophenone;2,6-fluoro-4-methoxybenzaldehyde;,6-DIFLUORO-4-METHOXYBENZALDEHYDE;2,6-DIFLUORO-4-METHOXYBENZALDEHYDE;Benzaldehyde, 2,6-difluoro-4-methoxy-;2,6-Difluoro-4-methoxybenzaldehyde 98%;2,6-DIFLUORO-4-METHOXYBENZALDEHYDE ISO 9001：2015 REACH;3,5-Difluoro-4-formylanisole, 2,6-Difluoro-p-anisaldehyde
- CBNumber
- CB2330994
- Molecular Formula
- C8H6F2O2
- Formula Weight
- 172.13
- MOL File
- 256417-10-4.mol
2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Property
- Melting point:
- 73-77 °C(lit.)
- Boiling point:
- 207.1±35.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Faint Gold
- Sensitive
- Air Sensitive
- InChIKey
- ZYABCGOTMDPUDD-UHFFFAOYSA-N
- CAS DataBase Reference
- 256417-10-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 38-41
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D446220
- Product name
- 2,6-Difluoro-4-methoxybenzaldehyde
- Packaging
- 25g
- Price
- $690
- Updated
- 2021/12/16
- Product number
- 033431
- Product name
- 2,6-Difluoro-4-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 033431
- Product name
- 2,6-Difluoro-4-methoxybenzaldehyde
- Packaging
- 5g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- W4895
- Product name
- 2,6-Difluoro-4-methoxybenzaldehyde
- Packaging
- 5g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- PC9939
- Product name
- 2,6-Difluoro-4-methoxybenzaldehyde
- Purity
- 98%
- Packaging
- 10g
- Price
- $66
- Updated
- 2021/12/16
2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Uses
2,6-Difluoro-4-methoxybenzaldehyde, is a versatile building block used for the synthesis of more complex pharmaceutical and biologically active compounds. It is shown to be involved in the preparation of potent and orally available G protein-coupled receptor 40 agonists, used the treatment of type 2 diabetes.
Synthesis
4885-02-3
93343-10-3
608515-57-7
256417-10-4
The general procedure for the synthesis of 2,4-difluoro-6-methoxybenzaldehyde (Intermediate 26B) and 2,6-difluoro-4-methoxybenzaldehyde (Intermediate 26A) from 1,1-dichlorodimethyl ether and 3,5-difluoroanisole is as follows (Intermediates 26A and 26B were prepared similarly to the method described in WO 2004046133): to a stirred 3 ,5-difluoroanisole (1.0 g, 7.0 mmol) to a stirred solution of dichloromethane (6 mL) was slowly added titanium tetrachloride (1.23 mL, 11.2 mmol) and dichloromethyl methyl ether (0.63 mL, 7.0 mmol) dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour and subsequently poured into ice water (50 mL). The reaction mixture was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, washed sequentially with H2O (50 mL) and brine (50 mL), dried with Na2SO4 and filtered. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 0 to 20% EtOAc/hexane as eluent to isolate 2,6-difluoro-4-methoxybenzaldehyde (Intermediate 26A, less polar component, 230 mg, 19% yield) and 2,4-difluoro-6-methoxybenzaldehyde (Intermediate 26B, more polar component, 740 mg, 62% yield), both as a white solid. 1H NMR (400 MHz, CDCl3) data of intermediate 26A: δ 3.85 (s, 3H), 6.47 (d, J=10.55Hz, 2H), 10.17 (s, 1H). 1H NMR (400MHz, CDCl3) data for intermediate 26B: δ 3.91 (s, 3H), 6.43-6.51 (m, 2H), 10.30 (s, 1H).
References
[1] Patent: WO2007/30582, 2007, A2. Location in patent: Page/Page column 90
2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE manufacturers
- Product
- 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE 256417-10-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-26
- Product
- ,6-DIFLUORO-4-METHOXYBENZALDEHYDE 256417-10-4
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07