ChemicalBook > CAS DataBase List > 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE

2,6-DIFLUORO-4-METHOXYBENZALDEHYDE

Product Name: 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
CAS No.: 256417-10-4
Chemical Name: 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE
Synonyms: 5-Fluoroacetophenone;2,6-fluoro-4-methoxybenzaldehyde;,6-DIFLUORO-4-METHOXYBENZALDEHYDE;2,6-DIFLUORO-4-METHOXYBENZALDEHYDE;Benzaldehyde, 2,6-difluoro-4-methoxy-;2,6-Difluoro-4-methoxybenzaldehyde 98%;2,6-DIFLUORO-4-METHOXYBENZALDEHYDE ISO 9001：2015 REACH;3,5-Difluoro-4-formylanisole, 2,6-Difluoro-p-anisaldehyde
CBNumber: CB2330994
Molecular Formula: C8H6F2O2
Formula Weight: 172.13
MOL File: 256417-10-4.mol

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2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Property

Melting point:: 73-77 °C(lit.)
Boiling point:: 207.1±35.0 °C(Predicted)
Density: 1.289±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: Faint Gold
Sensitive: Air Sensitive
InChIKey: ZYABCGOTMDPUDD-UHFFFAOYSA-N
CAS DataBase Reference: 256417-10-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 38-41
Safety Statements: 26-36/37/39
WGK Germany: 3
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: D446220
Product name: 2,6-Difluoro-4-methoxybenzaldehyde
Packaging: 25g
Price: $690
Updated: 2021/12/16

Oakwood

Product number: 033431
Product name: 2,6-Difluoro-4-methoxybenzaldehyde
Packaging: 1g
Price: $15
Updated: 2021/12/16

Oakwood

Product number: 033431
Product name: 2,6-Difluoro-4-methoxybenzaldehyde
Packaging: 5g
Price: $35
Updated: 2021/12/16

AK Scientific

Product number: W4895
Product name: 2,6-Difluoro-4-methoxybenzaldehyde
Packaging: 5g
Price: $49
Updated: 2021/12/16

Apolloscientific

Product number: PC9939
Product name: 2,6-Difluoro-4-methoxybenzaldehyde
Purity: 98%
Packaging: 10g
Price: $66
Updated: 2021/12/16

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2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Uses

2,6-Difluoro-4-methoxybenzaldehyde, is a versatile building block used for the synthesis of more complex pharmaceutical and biologically active compounds. It is shown to be involved in the preparation of potent and orally available G protein-coupled receptor 40 agonists, used the treatment of type 2 diabetes.

Synthesis

4885-02-3

93343-10-3

608515-57-7

256417-10-4

The general procedure for the synthesis of 2,4-difluoro-6-methoxybenzaldehyde (Intermediate 26B) and 2,6-difluoro-4-methoxybenzaldehyde (Intermediate 26A) from 1,1-dichlorodimethyl ether and 3,5-difluoroanisole is as follows (Intermediates 26A and 26B were prepared similarly to the method described in WO 2004046133): to a stirred 3 ,5-difluoroanisole (1.0 g, 7.0 mmol) to a stirred solution of dichloromethane (6 mL) was slowly added titanium tetrachloride (1.23 mL, 11.2 mmol) and dichloromethyl methyl ether (0.63 mL, 7.0 mmol) dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour and subsequently poured into ice water (50 mL). The reaction mixture was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, washed sequentially with H2O (50 mL) and brine (50 mL), dried with Na2SO4 and filtered. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 0 to 20% EtOAc/hexane as eluent to isolate 2,6-difluoro-4-methoxybenzaldehyde (Intermediate 26A, less polar component, 230 mg, 19% yield) and 2,4-difluoro-6-methoxybenzaldehyde (Intermediate 26B, more polar component, 740 mg, 62% yield), both as a white solid. 1H NMR (400 MHz, CDCl3) data of intermediate 26A: δ 3.85 (s, 3H), 6.47 (d, J=10.55Hz, 2H), 10.17 (s, 1H). 1H NMR (400MHz, CDCl3) data for intermediate 26B: δ 3.91 (s, 3H), 6.43-6.51 (m, 2H), 10.30 (s, 1H).

References

[1] Patent: WO2007/30582, 2007, A2. Location in patent: Page/Page column 90

2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DIFLUORO-4-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,6-DIFLUORO-4-METHOXYBENZALDEHYDE 256417-10-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-26

Career Henan Chemical Co

Product: ,6-DIFLUORO-4-METHOXYBENZALDEHYDE 256417-10-4
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-07

256417-10-4, 2,6-DIFLUORO-4-METHOXYBENZALDEHYDERelated Search:

2,6-DIFLUORO-4-METHOXYBENZALDEHYDE 2,6-DIFLUORO-4-METHOXYBENZOIC ACID 2',6'-DIFLUORO-4'-METHOXYACETOPHENONE 3,4-Difluoro-2-methoxyaniline 2,4-DIFLUORO-3-METHOXYANILINE 2,3-Difluoro-4-methoxybenzaldehyde 2,4-DIFLUORO-3-METHOXYBENZALDEHYDE 2,3-DIFLUORO-6-METHOXYANILINE 2,3-Difluoro-6-methoxybenzaldehyde98%,2,3-Difluoro-6-methoxybenzaldehyde 98%,2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 4,5-DIFLUORO-2-METHOXYBENZALDEHYDE 3,5-Difluoro-4-methoxybenzaldehyde 99%,3,5-Difluoro-4-methoxybenzaldehyde99%,3,5-DIFLUORO-4-METHOXYBENZALDEHYDE 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE 3,5-DIFLUORO-4-METHOXYANILINE 2,6-DIFLUORO-4-METHOXYBENZAMIDE 4-BENZYLOXY-2,6-DIFLUORO-BENZOIC ACID 3,6-DIFLUORO-2-METHOXYBENZALDEHYDE 4-ACETOXY-2,3,5,6-TETRAFLUOROBENZOIC ACID 2,5-DIFLUORO-4-METHOXYBENZALDEHYDE

2,6-DIFLUORO-4-METHOXYBENZALDEHYDE

2,6-fluoro-4-methoxybenzaldehyde

3,5-Difluoro-4-formylanisole, 2,6-Difluoro-p-anisaldehyde

2,6-Difluoro-4-methoxybenzaldehyde 98%

,6-DIFLUORO-4-METHOXYBENZALDEHYDE

Benzaldehyde, 2,6-difluoro-4-methoxy-

2,6-DIFLUORO-4-METHOXYBENZALDEHYDE ISO 9001：2015 REACH

5-Fluoroacetophenone

256417-10-4

Building Blocks

Carbonyl Compounds

Organic Building Blocks

Aldehydes

Aromatic Aldehydes & Derivatives (substituted)

Aldehydes

Carbonyl Compounds