ChemicalBook > CAS DataBase List > 1-BROMO-2-BUTYNE

1-BROMO-2-BUTYNE

Product Name
1-BROMO-2-BUTYNE
CAS No.
3355-28-0
Chemical Name
1-BROMO-2-BUTYNE
Synonyms
1-Bromobut-2-yne;2-BUTYNYL BROMIDE;1-Bromobut-2-butyne;1-Brom-2-Butin;Linagliptin INT4;1-BROMO-2-BUTYNE;1-broMo -2-Ding Que;1-Bromobut-2-yne 95%;1-Bromo-2-butyne,98%;1-BROMO-2-BUTYNE 98%
CBNumber
CB0363349
Molecular Formula
C4H5Br
Formula Weight
132.99
MOL File
3355-28-0.mol
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1-BROMO-2-BUTYNE Property

Boiling point:
40-41 °C/20 mmHg (lit.)
Density 
1.519 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.508(lit.)
Flash point:
97 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Miscible with acetonitrile.
form 
Liquid
Specific Gravity
1.519
color 
Clear pale yellow-greenish
BRN 
605306
InChIKey
LNNXOEHOXSYWLD-UHFFFAOYSA-N
CAS DataBase Reference
3355-28-0(CAS DataBase Reference)
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Safety

Risk Statements 
10
Safety Statements 
16-24/25
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
F 
10-23
HazardClass 
3
PackingGroup 
III
HS Code 
29033990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
427292
Product name
1-Bromo-2-butyne
Purity
99%
Packaging
1g
Price
$31.2
Updated
2024/03/01
Sigma-Aldrich
Product number
427292
Product name
1-Bromo-2-butyne
Purity
99%
Packaging
5g
Price
$145
Updated
2024/03/01
TCI Chemical
Product number
B2190
Product name
1-Bromo-2-butyne
Purity
>96.0%(GC)
Packaging
1g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
B2190
Product name
1-Bromo-2-butyne
Purity
>96.0%(GC)
Packaging
5g
Price
$104
Updated
2024/03/01
Alfa Aesar
Product number
L20134
Product name
1-Bromo-2-butyne, 98%
Packaging
5g
Price
$130
Updated
2024/03/01
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1-BROMO-2-BUTYNE Chemical Properties,Usage,Production

Chemical Properties

Clear pale yellow-greenish liquid

Uses

1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds.

Preparation

1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction.

General Description

1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin.

1-BROMO-2-BUTYNE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BROMO-2-BUTYNE Suppliers

Americas 1 Belgium 2 Canada 1 China 311 Europe 2 France 2 Germany 4 India 25 Ireland 1 Israel 2 Japan 3 Switzerland 2 The Netherlands 1 United Kingdom 10 United States 38 Global 405
Carbosynth
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Manchester Organics
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Apollo Scientific Ltd.
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CARBONE SCIENTIFIC CO.,LTD
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UK GREEN SCIENTIFIC CO.,LIMITED
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Fluorochem Ltd
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View Lastest Price from 1-BROMO-2-BUTYNE manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
1-BROMO-2-BUTYNE 3355-28-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Hebei Dangtong Import and export Co LTD
Product
1-BROMO-2-BUTYNE 3355-28-0
Price
US $30.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-10
Hebei Chuanghai Biotechnology Co,.LTD
Product
1-BROMO-2-BUTYNE 3355-28-0
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-22

3355-28-0, 1-BROMO-2-BUTYNERelated Search:

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  • 1-BROMO-2-BUTYNE
  • 2-BUTYNYL BROMIDE
  • 1-Bromobut-2-yne 95%
  • 1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98%1-BROMO-2-BUTYNE, 98%
  • 1-BROMO-2-BUTYNE 98%
  • 1-Bromo-2-butyne,98%
  • But-2-yn-1-yl bromide
  • 1-broMo -2-Ding Que
  • 1-BroMo-2-butyne, 96.0%(GC)
  • 1-Bromobut-2-yne
  • Linagliptin INT4
  • 1-Bromo-2-butyne (Linagliptin)
  • 1-BROMO-2-BUTYNE, 2-BUTYNYL BROMIDE
  • 1-Bromobut-2-butyne
  • 1-Bromo-2-butyne &gt
  • 1-BROMO-2-BUTYNE ISO 9001：2015 REACH
  • Linagliptin intermediates，1-bromo-2-butyne
  • 1-Brom-2-Butin
  • Rilpivirine Impurity 18
  • 3355-28-0
  • 2563355-28-0
  • CH3CCCH2Br
  • Br1C4H5
  • CH3C8801CCH2Br
  • C4H5Br
  • Organic Building Blocks
  • Halogenated Hydrocarbons
  • Acetylenes
  • Functionalized Acetylenes
  • Alkynyl
  • Building Blocks
  • Intermediates
  • Acetylenes
  • Functionalized Acetylenes
  • Alkynyl
  • Halogenated Hydrocarbons
  • Organic Building Blocks