2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl

Reaction

Product Name: 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl
CAS No.: 240417-00-9
Chemical Name: 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl
Synonyms: PhDavePhos;PhDave-Phos 97%;2-Diphenylphosphino-2;(N,N-DIMETHYLAMINO)BIPHENYL;2-Diphenylphosphino-2'-(N,N-di;2-Diphenylphosphino-2`-dimethylaminobiphenyl;2-DIMETHYLAMINO-2'-(DIPHENYLPHOSPHINO)BIPHENYL;2-DiphenylphosphiNA-2'-(N,N-diMethylaMiNA)biphenyl;[2-(2-Dimethylaminophenyl)phenyl]diphenylphosphine;2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl
CBNumber: CB0364760
Molecular Formula: C26H24NP
Formula Weight: 381.45
MOL File: 240417-00-9.mol

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2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Property

Melting point:: 126-128 °C
Boiling point:: 514.6±43.0 °C(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 4.96±0.18(Predicted)
form: Powder, Crystals, Crystalline Powder and/or Chunks
color: White to yellow
Water Solubility: insoluble
InChIKey: JGFXUYLYPITYGR-UHFFFAOYSA-N
CAS DataBase Reference: 240417-00-9

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-36/37/39
WGK Germany: 3
TSCA: No
HazardClass: IRRITANT
HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 695882
Product name: PhDave-Phos
Purity: 97%
Packaging: 1g
Price: $113.96
Updated: 2025/07/31

Sigma-Aldrich

Product number: 695882
Product name: PhDave-Phos
Purity: 97%
Packaging: 5g
Price: $387
Updated: 2023/06/20

Strem Chemicals

Product number: 15-1745
Product name: 2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% PhDavePhos
Packaging: 500mg
Price: $33
Updated: 2024/03/01

Strem Chemicals

Product number: 15-1745
Product name: 2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% PhDavePhos
Packaging: 2g
Price: $98
Updated: 2024/03/01

Strem Chemicals

Product number: 15-1745
Product name: 2-Diphenylphosphino-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% PhDavePhos
Packaging: 10g
Price: $394
Updated: 2024/03/01

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2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties,Usage,Production

Reaction

Useful ligand for sterically hindered substrates in the Pd-catalyzed amination reactions of aryl bromides.
Ligand used for the Cu-catalyzed phosphorylation of alcohols.
Ligand for Pd-catalyzed C-H benzylation.
Ligand for palladium-catalyzed [4 + 2] benzannulation reaction.

Chemical Properties

white to yellow powder, crystals, crystalline

Uses

suzuki reaction

reaction suitability

reaction type: Cross Couplings
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-C Bond Formation

Synthesis

119326-02-2

15475-27-1

240417-00-9

The compound (CAS:119326-02-2) (29.6 mg, 0.0510 mmol) was transferred to an argon protected 10 mL Schlenk flask. The flask was evacuated and filled with argon three times to remove air. Subsequently, anhydrous THF (3.0 mL) was added using a syringe under argon atmosphere. A THF solution (0.46 mL, 0.23 mmol) of 0.5 M LiPPh2 was slowly added dropwise under stirring for a controlled time of 5 min. During the reaction, the color of the mixture changed from yellow to dark red and finally to dark yellow. The reaction mixture was stirred under argon protection at room temperature for 18 hours. After completion of the reaction, the solvent was removed using a rotary evaporator. The crude product was dissolved in dichloromethane (0.5 mL) and purified by preparative thin layer chromatography (silica gel, unfolding reagent was benzene:acetone=10:1). The final isolation afforded the target product (S)-2-diphenylphosphino-2'-(N,N-dimethylamino)biphenyl as a light yellow liquid in 46% yield (15.6 mg).

References

[1] Journal of Organometallic Chemistry, 2013, vol. 745-746, p. 356 - 362

2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl Suppliers

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View Lastest Price from 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl 240417-00-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-14

XINXIANG RUNYU MATERIAL CO., LTD.

Product: 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl 240417-00-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 0.98
Supply Ability: 500kg
Release date: 2021-11-29

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Diphenylphosphino-2'-(N,N-dimethylamino)biphenyl 240417-00-9
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-01-14

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C26H24NP

Achiral Phosphine

Aryl Phosphine

Buchwald Ligands Series

Buchwald Ligands&Precatalysts

Biphenyl & Diphenyl ether

Phosphines