Uses Reactions
ChemicalBook > CAS DataBase List > 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

Uses Reactions
Product Name
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
CAS No.
657408-07-6
Chemical Name
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Synonyms
98% SPhos;Dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane;dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane;6´NS-PHOS;SPhos 97%;SPhos, >=98%;REF DUPL: S-PHOS;-diMethoxybiphenyl;S-Phos, ChemDose(TM) tablets
CBNumber
CB8634850
Molecular Formula
C26H35O2P
Formula Weight
410.53
MOL File
657408-07-6.mol
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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Property

Melting point:
164-166°C
Boiling point:
513.3±40.0 °C(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Chloroform
form 
crystal
color 
white
Sensitive 
Air Sensitive
InChIKey
VNFWTIYUKDMAOP-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
24/25-36/37
WGK Germany 
3
TSCA 
No
HS Code 
2931499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
1G
Price
$31.44
Updated
2024/03/01
Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
5G
Price
$143
Updated
2024/03/01
Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
25G
Price
$270.4
Updated
2024/03/01
Sigma-Aldrich
Product number
932191
Product name
SPhos ChemBeads
Packaging
1g
Price
$287
Updated
2024/03/01
Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
250G
Price
$736
Updated
2024/03/01
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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Chemical Properties,Usage,Production

Uses

SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. 
SPhos may be used as a ligand in the following processes:
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.

Reactions

  1. Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
  2. Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
  3. Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
  4. Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
  5. Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
  6. Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
  7. Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
  8. Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids
  9. and esters.

Chemical Properties

White solid

Uses

S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.

Uses

suzuki reaction

General Description

SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials

Raw materials

Dicyclohexylchlorophosphine 1,3-Dimethoxybenzene Tetrahydrofuran 1,2-Dibromobenzene Ethyl acetate PETROLEUM ETHER Magnesium n-Butyllithium

Preparation Products

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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Suppliers

Americas 1 Belgium 1 Canada 3 China 328 Europe 1 France 2 Germany 6 India 10 Italy 1 Japan 3 Russia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 9 United States 35 Global 405
Shanghai Yihui Biochemical Technology Co., LTD
Tel
17301829151
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3506285926@qq.com
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China
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58
Sinocompound Catalysts Co., Ltd.
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0512-67216630 67216634
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0512-56316689
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sales@sinocompound.com
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China
ProdList
278
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64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 18112977050
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cb6@aikonchem.com
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China
ProdList
16684
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50
Puyang Huicheng Electronic Material Co. Ltd.
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0393-0393-0393-8910800 15039333257
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0393-8912775
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info@huichengchem.com
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China
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Shaanxi Rock New Materials Co., Ltd.
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0917-8888777, 3380777,18691786767; 15619786767
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xuya@bjrock.com
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China
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Aikon International Limited
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025-66028182 18112977050
Fax
(3)02557626880
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cfzhang@aikonchem.com
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China
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15818
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BeiJing Greenchem Technology Co.,Ltd.
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131-21959385 15640741633
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010-62925455
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chemrocking@bjgreenchem.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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94657
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
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market03@meryer.com
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China
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40228
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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View Lastest Price from 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl manufacturers

Jinan Finer Chemical Co., Ltd
Product
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 657408-07-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
200mt
Release date
2022-01-25
XINXIANG RUNYU MATERIAL CO., LTD.
Product
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 657408-07-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
500kg
Release date
2021-11-23
Hebei Chuanghai Biotechnology Co,.LTD
Product
SPHOS 657408-07-6
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21

657408-07-6, 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenylRelated Search:

X-PHOS 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Diphenyldimethoxysilane Dimethyldimethoxysilane trans-Bifenthtin Bifendate 1,1-Dimethoxyethane 2-(Dicyclohexylphosphino)biphenyl 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIISOPROPOXYBIPHENYL DI-N-PENTYLPHENYLPHOSPHINE 2-(DICYCLOHEXYLPHOSPHINO)-2'-HYDROXYBIPHENYL DICYCLOHEXYLPHOSPHINE CYCLOHEXYLPHOSPHINE Dicyclohexylphenylphosphine 2'-DICYCLOHEXYLPHOSPHINO-2,6-DIMETHOXY-3-SULFONATO-1,1'-BIPHENYL HYDRATE SODIUM SALT 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

  • 98% SPhos
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  • SPhos 97%
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  • S-Phos, ChemDose? tablets
  • dicyclohexyl({2-[(2,6-dimethoxyphenyl)methyl]phenyl}methyl)phosphane
  • 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl, min. 98%
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  • S-phos, 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Sphos
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  • 2-(Dicyclohexylphosphanyl)-2',6'-dimethoxybiphenyl 98%
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 657408-07-6 250g
  • -Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
  • 2-DICYLOHEXYLPHOSPHINO-2,6-DIMETHOXYBIPHENYL
  • Phosphine,dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)-
  • SPhos, >=98%
  • 2-Dicyclohexylphosphino-2’,6’-dimethoxy-1,1’-biphenyl (S-Phos)
  • 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIMETHOXY-1,1'-BIPHENYL, MIN. 98% S-PHOS
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl, min. 98%
  • S-Phos impregnated tablets, ChemDose(R), S-Phos tablets, 2-Dicyclohexylphosphino-2μ,6μ-dimethoxybiphenyl impregnated tablets
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  • 6&acute
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl, 98+%
  • REF DUPL: S-PHOS
  • Dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybipheny
  • Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine
  • 2-Dicyclohexylphosphino-2&acute
  • -diMethoxybiphenyl
  • S-PHOS, 2-Dicyclohexylphosphino-2,6-di-Methyloxy-1,1-biphenyl
  • phosphino-2’,6’-dimethoxybiphenyL
  • phosphino-2',6'-dimethoxy-1,1'-biphenyL
  • NS-PHOS
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  • 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl,min.98%
  • 2-Dicyclohexyphosphino-2'6'-dimethoxy-1,1'-biphenyl (Sphos)
  • dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane
  • S-Phos (2-Dicyclohexylphosphino-2,6-Dimethoxybiphenyl) extrapure, 98%
  • Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine(S-PHOS)
  • 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIMETHOXY-1,1'-BIPHENYL
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl(Sphos)
  • Dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine
  • dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane
  • Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine
  • 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl, min. 98%
  • 2-Dicyclohexylphosphino-2'',6''-dimethoxybiphenyl
  • Bromo(tri-tert-butylphosphine)palladium()dimer
  • 657408-07-6