Reaction
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X-PHOS

Reaction
Product Name
X-PHOS
CAS No.
564483-18-7
Chemical Name
X-PHOS
Synonyms
5-BROMO-4-CHLORO-3-INDOLYL PHOSPHATE;2-Dicyclohexylphosphino-2;dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane;X-PH0S;dicyclohexyl-[2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane;X-PHOS;98% XPhos;2-(DicycL;XPhos 97%;XPhos, >=98%
CBNumber
CB3357527
Molecular Formula
C33H49P
Formula Weight
476.72
MOL File
564483-18-7.mol
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X-PHOS Property

Melting point:
187-190 °C(lit.)
Boiling point:
569.8±50.0 °C(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Benzene (Slightly)
form 
Powder
color 
white
Sensitive 
Air Sensitive
Stability:
Air Sensitive
InChIKey
UGOMMVLRQDMAQQ-UHFFFAOYSA-N
CAS DataBase Reference
564483-18-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22-40
Safety Statements 
37/39-26-36/37
WGK Germany 
3
TSCA 
No
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
638064
Product name
XPhos
Purity
97%
Packaging
1g
Price
$92.5
Updated
2024/03/01
Sigma-Aldrich
Product number
638064
Product name
XPhos
Purity
97%
Packaging
5g
Price
$171
Updated
2024/03/01
TCI Chemical
Product number
D5038
Product name
2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl
Purity
>98.0%(GC)
Packaging
1g
Price
$98
Updated
2024/03/01
TCI Chemical
Product number
D5038
Product name
2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl
Purity
>98.0%(GC)
Packaging
5g
Price
$288
Updated
2024/03/01
Strem Chemicals
Product number
15-1149
Product name
2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% XPhos
Packaging
500mg
Price
$33
Updated
2024/03/01
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X-PHOS Chemical Properties,Usage,Production

Reaction

  1.  Exceptional ligands for Pd-catalyzed amination and amidation of aryl sulfonates.
  2.  Ligand used for the Pd-catalyzed Suzuki-Miyaura coupling reaction and carbonyl enolate coupling.
  3.  Ligand used for the chemoselective amination of aryl chlorides.
  4.  Ligand used for the Pd-catalyzed borylation of aryl chlorides, for the formation of trifluoroborates.
  5.  Ligand used for the Pd-catalyzed amination of vinyl halides and triflates.
  6.  Ligand used for the Pd-catalyzed three-component synthesis of indoles.
  7.  Ligand used for the Pt-catalyzed regioselective hydrosilylation of functionalized terminal arylalkynes.
  8.  Ligand used for the Pd-catalyzed synthesis of carbazoles.
  9.  Ligand used for the Pd-catalyzed Suzuki-Miyaura coupling of aryl chloride and NHC-boranes.
  10.  Ligand used for the direct arylation of picoline N-oxide.
  11.  Ligand used for the Negishi coupling of 2-heterocyclic organozinc reagents.
  12.  Catalyst for a phosphine-catalyzed Heine reaction.
  13.  Ligand used for the palladium-catalyzed oxidative coupling of indoles and heteroarenes.
  14.  Ligand used for the silver-catalyzed hydrogenation of aldehydes.
  15.  Ligand used for the palladium-catalyzed cyanation of heterycyclic halides.



Chemical Properties

White crystalline powder

Uses

suzuki reaction

Uses

Exceptional ligands for Pd-catalyzed amination and amidation of aryl sulfonates. XPHOS is used as a regent in the synthesis of novel [1,2,4]triazolo[4,3-a]pyrazine derivatives as potential selective c-met inhibitors with improved pharmacokinetic properties.

General Description

This product has been enhanced for catalytic efficiency.

reaction suitability

reagent type: catalyst
reaction type: Cross Couplings

X-PHOS Preparation Products And Raw materials

Raw materials

2-Bromochlorobenzene Dicyclohexylchlorophosphine Carbon tetrachloride Hydroquinone Tetrahydrofuran 1,3,5-Triisopropylbenzene Ethyl acetate Copper(I) chloride Government regulation Dichloromethane Methanol Iron Magnesium

Preparation Products

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X-PHOS Suppliers

Americas 1 Belgium 3 Canada 2 China 401 Europe 1 France 3 Germany 9 India 15 Ireland 1 Italy 1 Japan 2 Norway 1 Russia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 10 United States 42 Global 498
Xinxiang Runyu Material Co., Ltd.
Tel
166-166-37336996 15690792173
Fax
0373-7759608
Email
chenxi.song@runvmat.com
Country
China
ProdList
299
Advantage
55
Shanghai Yihui Biochemical Technology Co., LTD
Tel
17301829151
Email
3506285926@qq.com
Country
China
ProdList
225
Advantage
58
Sinocompound Catalysts Co., Ltd.
Tel
0512-67216630 67216634
Fax
0512-56316689
Email
sales@sinocompound.com
Country
China
ProdList
280
Advantage
64
Puyang Huicheng Electronic Material Co. Ltd.
Tel
0393-0393-0393-8910800 15036113989
Fax
0393-8912775
Email
info@huichengchem.com
Country
China
ProdList
564
Advantage
64
Zhengzhou HQ Material Co., Ltd.
Tel
0371-67759225 13526468238
Fax
+86-37155919558
Email
sales@hqmat.com
Country
China
ProdList
483
Advantage
60
Shanghai Chino Pharmaceutical Technology Co., Ltd
Tel
021-021-51557188 15901710861
Fax
QQ: 569058060
Email
sales@channelpharm.com
Country
China
ProdList
1216
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
BeiJing Greenchem Technology Co.,Ltd.
Tel
131-21959385 15640741633
Fax
010-62925455
Email
chemrocking@bjgreenchem.com
Country
China
ProdList
269
Advantage
58
Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-83946278 13820503911
Fax
022-83945176
Email
sales@creasyn.com
Country
China
ProdList
996
Advantage
68
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from X-PHOS manufacturers

Shanghai UCHEM Inc.
Product
2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl 564483-18-7
Price
US $26.00-461.00/g
Min. Order
25g
Purity
0.99
Supply Ability
100kg
Release date
2023-10-25
Speranza Chemical Co., Ltd.
Product
2-(DICYCLOHEXYLPHOSPHINO)-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL 564483-18-7
Price
US $0.00-0.00/KG
Min. Order
5KG
Purity
98%
Supply Ability
25KG
Release date
2024-11-05
Hebei Zhuanglai Chemical Trading Co Ltd
Product
X-PHOS 564483-18-7
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-12-17

564483-18-7, X-PHOSRelated Search:

5-BROMO-4-CHLORO-3-INDOLYL PHOSPHATE DIPOTASSIUM SALT 2-(Dicyclohexylphosphino)biphenyl DI-N-PENTYLPHENYLPHOSPHINE DIBUTYLPHENYLPHOSPHINE 2-(Dicyclohexylphosphino)-2'-methylbiphenyl X-PHOS Dicyclohexylphenylphosphine 5-BROMO-4-CHLORO-3-INDOLYL PHOSPHATE DISODIUM SALT PNP-PHOS K PNP-PHOS 2 CHX PNP-PHOS DINA HEXAHYDRATE 5-Bromo-4-chloro-3-indolyl phosphate hydrate disodium salt PHOS-ALPHA-D-GLC 2H2O 5-Bromo-4-chloro-3-indolyl phosphate p-toluidine salt PNP-PHOS DINA CYCLOHEXYLPHOSPHINE DICYCLOHEXYLPHOSPHINE GOAT F(AB')2 ANTI-HUMAN LAMBDA (F+B) ALK PHOS

  • X-PHOS
  • 5-BROMO-4-CHLORO-3-INDOLYL PHOSPHATE
  • 2-(DICYCLOHEXYLPHOSPHINO)-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL
  • 2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRIISO-PROPYL-1,1'-BIPHENYL
  • 2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
  • 2-Dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl, X-PHOS
  • 2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl,min.98%X-Phos
  • -biphenyl]-2-yl]phosphane
  • (2-(2,4,6-triisopropylphenethyl)phenyl)dicyclohexylphosphine(X-Phos)
  • X-PH0S
  • 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl, 98+%
  • ChemDose(R), X-Phos impregnated tablets, 2-Dicyclohexylphosphino-2μ,4μ,6μ-triisopropylbiphenyl impregnated tablets
  • X-Phos, ChemDose(R) tablets
  • 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbip
  • 2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,
  • 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl ,97%
  • 2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl,XPhos
  • 2-Dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl, 98+% X-PHOS
  • 98% XPhos
  • 2-(DicyclohexylphosphiNA)-2',4',6'-triisopropylbiphenyl
  • Dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine
  • 2,,4',6'-Diisopropyl-1,1'-biphenyl-2-yldicyclohexylphosphine
  • 2-(Dicyclohexylphosphino)-2',4
  • 2-(Dicyclohexylphosphanyl)-2',4',6'-tris(isopropyl)biphenyl
  • Dicyclohexyl[2',4',6'-tris(prop-2-yl)biphenyl-2-yl]phosphine, Dicyclohexyl[2',4',6'-tris(prop-2-yl)biphenyl-2-yl]phosphane, X-phos
  • 2-(DicycL
  • phosphino)-2',4',6'-tri-i-propyL
  • Dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine
  • Phosphine, dicyclohexyl[2',4',6'-tris(1-Methylethyl)[1,1'-biphenyl]-2-yl]-
  • XPhos 97%
  • 2-Dicyclohexylphosphino-2
  • 2-(DICYCLOHEXYLPHOSPHINO)-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL OR X-PHOS
  • (2-(2,4,6-triisopropylphenethyl)phenyl)dicyclohexylphosphine
  • X-PHOS,2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl
  • XPhos, >=98%
  • Dicyclohexyl[2-(2,4,6-triisopropylphenyl)phenyl]phosphane
  • X-Phos, ChemDose? tablets
  • 2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98%
  • dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane
  • dicyclohexyl[2',4',6'-tris(propan-2-yl)-[1,1'-biphenyl]-2-yl]phosphane
  • 2-Dicyclohexylphosphino-2',4',6'-t
  • dicyclohexyl-[2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
  • [2'-(methylamino)-[1,1'-biphenyl]-2-yl]palladio methanesulfonate
  • X-Phos, ChemDose(TM) tablets
  • -1,1'-biphenyL
  • 2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl,min.98%
  • X-Phos ( 2-dicyclohexylphosphino-2’,4’,6’-triisopropylbiphenyl)
  • 2-Dicyclohexylphosphino-2',4',6'-trisopropyl-1,1'-biphenyl(X-phos)
  • 2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRIISO-PROPYL-1,1'-BIPHENYL,xphos
  • X-Phos (2-Dicyclohexylphosphino-2,4,6-Triisopropylbiphenyl) extrapure, 98%
  • 2-Dicyclohexylphosphate-2 ', 4', 6 '- triisopropylbiphenyl
  • 2-dicyclohexylphosphine 2',4',6' -triisopropyl biphenyl
  • 2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl
  • 2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRIISO-PROPYL-1,1'-BIPHENYL
  • XPhos(2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl)
  • 2,,4',6'-Diisopropyl-1,1'-biphenyl-2-yldicyclohexylphosphine
  • 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl
  • dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane