Uses Reactions
ChemicalBook > CAS DataBase List > 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

Uses Reactions
Product Name
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
CAS No.
657408-07-6
Chemical Name
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Synonyms
98% SPhos;Dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane;dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane;6´NS-PHOS;SPhos 97%;SPhos, >=98%;REF DUPL: S-PHOS;-diMethoxybiphenyl;S-Phos, ChemDose(TM) tablets
CBNumber
CB8634850
Molecular Formula
C26H35O2P
Formula Weight
410.53
MOL File
657408-07-6.mol
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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Property

Melting point:
164-166°C
Boiling point:
513.3±40.0 °C(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Chloroform
form 
crystal
color 
white
Sensitive 
Air Sensitive
InChIKey
VNFWTIYUKDMAOP-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
24/25-36/37
WGK Germany 
3
TSCA 
No
HS Code 
2931499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
1G
Price
$31.44
Updated
2024/03/01
Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
5G
Price
$143
Updated
2024/03/01
Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
25G
Price
$270.4
Updated
2024/03/01
Sigma-Aldrich
Product number
932191
Product name
SPhos ChemBeads
Packaging
1g
Price
$287
Updated
2024/03/01
Sigma-Aldrich
Product number
901906
Product name
SPhos
Purity
95%
Packaging
250G
Price
$736
Updated
2024/03/01
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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Chemical Properties,Usage,Production

Uses

SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. 
SPhos may be used as a ligand in the following processes:
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.

Reactions

  1. Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
  2. Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
  3. Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
  4. Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
  5. Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
  6. Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
  7. Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
  8. Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids
  9. and esters.

Chemical Properties

White solid

Uses

S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.

Uses

suzuki reaction

General Description

SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials

Raw materials

Dicyclohexylchlorophosphine 1,3-Dimethoxybenzene Tetrahydrofuran 1,2-Dibromobenzene Ethyl acetate PETROLEUM ETHER Magnesium n-Butyllithium

Preparation Products

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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Suppliers

Americas 1 Belgium 1 Canada 3 China 326 Europe 1 France 2 Germany 6 India 10 Italy 1 Japan 3 Russia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 9 United States 35 Global 403
TCI Chemicals (India) Pvt. Ltd.
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Sisco Research Laboratories Pvt. Ltd.
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Triveni chemicals
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Mehta Enterprise
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Reax Chemicals
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Spectrochem Private Limited
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Spectrochem Pvt., Ltd.
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Anand Agencies
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A.J Chemicals
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View Lastest Price from 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl manufacturers

Jinan Finer Chemical Co., Ltd
Product
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 657408-07-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
200mt
Release date
2022-01-25
Hebei Chuanghai Biotechnology Co,.LTD
Product
SPHOS 657408-07-6
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
R&D Scientific Inc.
Product
SPhos 657408-07-6
Price
US $1290.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-07-11

657408-07-6, 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenylRelated Search:

X-PHOS 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Diphenyldimethoxysilane Dimethyldimethoxysilane trans-Bifenthtin Bifendate 1,1-Dimethoxyethane 2-(Dicyclohexylphosphino)biphenyl 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIISOPROPOXYBIPHENYL DI-N-PENTYLPHENYLPHOSPHINE 2-(DICYCLOHEXYLPHOSPHINO)-2'-HYDROXYBIPHENYL DICYCLOHEXYLPHOSPHINE CYCLOHEXYLPHOSPHINE Dicyclohexylphenylphosphine 2'-DICYCLOHEXYLPHOSPHINO-2,6-DIMETHOXY-3-SULFONATO-1,1'-BIPHENYL HYDRATE SODIUM SALT 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

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  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 657408-07-6 250g
  • -Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
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  • 6&acute
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  • REF DUPL: S-PHOS
  • Dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane
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  • Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine
  • 2-Dicyclohexylphosphino-2&acute
  • -diMethoxybiphenyl
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  • S-Phos (2-Dicyclohexylphosphino-2,6-Dimethoxybiphenyl) extrapure, 98%
  • Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine(S-PHOS)
  • 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIMETHOXY-1,1'-BIPHENYL
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
  • 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl(Sphos)
  • Dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine
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  • 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl, min. 98%
  • 2-Dicyclohexylphosphino-2'',6''-dimethoxybiphenyl
  • Bromo(tri-tert-butylphosphine)palladium()dimer
  • 657408-07-6