Phenylbutazone

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Abstract Chemical Property Mechanism of action Pharmacokinetic Study Attention and Taboo Preparation Acute toxicity Flammability hazard properties Storage characteristics Extinguishing agent References

Product Name: Phenylbutazone
CAS No.: 50-33-9
Chemical Name: Phenylbutazone
Synonyms: PBZ;Benzone;4-Phenylbutazone;Bute;Butone;Azolid;Butalan;Butadione;Baotaisong;Butazolidin
CBNumber: CB0370134
Molecular Formula: C19H20N2O2
Formula Weight: 308.37
MOL File: 50-33-9.mol

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Phenylbutazone Property

Melting point:: 106-108 °C (lit.)
Boiling point:: 448.76°C (rough estimate)
Density: 1.1591 (rough estimate)
refractive index: 1.6140 (estimate)
storage temp.: 2-8°C
solubility: Practically insoluble in water, sparingly soluble in alcohol. It dissolves in alkaline solutions.
form: Powder
pka: 4.5(at 25℃)
color: White to almost white
Water Solubility: <0.1 g/100 mL at 23.5 ºC
Merck: 14,7277
BRN: 290080
Stability:: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey: VYMDGNCVAMGZFE-UHFFFAOYSA-N
LogP: 3.160
CAS DataBase Reference: 50-33-9(CAS DataBase Reference)
NIST Chemistry Reference: Phenylbutazone(50-33-9)
IARC: 3 (Vol. 13, Sup 7) 1987
EPA Substance Registry System: Phenylbutazone (50-33-9)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 36/37/38-20/21/22-42/43-45-36-11
Safety Statements: 36/37/39-26-45-22-53-36/37-16
RIDADR: 3249
WGK Germany: 3
RTECS: UQ8225000
TSCA: Yes
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29331990
Hazardous Substances Data: 50-33-9(Hazardous Substances Data)
Toxicity: LD50 oral in rabbit: 781mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2607
Product name: Phenylbutazone
Packaging: 500MG
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1531007
Product name: Phenylbutazone
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 250mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: 79184
Product name: Phenylbutazone
Purity: analytical standard
Packaging: 50mg
Price: $59.1
Updated: 2022/05/15

TCI Chemical

Product number: P1686
Product name: Phenylbutazone
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $32
Updated: 2024/03/01

TCI Chemical

Product number: P1686
Product name: Phenylbutazone
Purity: >98.0%(HPLC)(T)
Packaging: 500g
Price: $242
Updated: 2024/03/01

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Phenylbutazone Chemical Properties,Usage,Production

Abstract

Phenylbutazone, often referred to as "bute,"is a nonsteroidal anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis.
Phenylbutazone has been removed from the United States market due to the availability of newer drugs with less adverse effects. Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis and other musculoskeletal conditions.

Chemical Property

It is soluble in acetone, chloroform or benzene freely; soluble in ethanol or ether; hardly soluble in water; soluble in sodium hydroxide solution.

Mechanism of action

Recent studies have found that the generating mechanism from phenylbutazone anti-inflammatory, analgesic and anti-rheumatic effect is not due to pituitary-adrenal excitement may be due to drugs that inhibit the generation of inflammatory tissue inflammation related active substances, such as synthesis of prostaglandins, white blood cells activities and transfer, release and activity of lysosomal enzymes; pain may also inhibit prostaglandin synthesis results.

Pharmacokinetic Study

Oral absorption effect is quickly and completely, reached the peak plasma concentration after about 2 hours. Plasma protein binding rate is 98%. The apparent volume of distribution is 0.12L/kg, such as increasing the dose, volume of distribution has also increased, but the blood concentration does not increase. Therefore, when using repeatedly, the steady-state plasma concentration does not increase linearly. The half-life is 56 to 86 hours. It can cross the placenta into the milk. This product is metabolized by the liver, metabolites is hydroxy phenylbutazone and γ-hydroxy phenylbutazone, still active, The final metabolites are excreted in urine and a small amount of bile is excreted through the urine.

Attention and Taboo

The side effects of phenylbutazone incidence rate is about 10%~20%, gastrointestinal irritation can cause nausea, vomiting, abdominal pain, constipation, overdose can cause peptic ulcer, blood in the stool. Damages also occur in other systems, such as rash, dizziness, hematuria, hepatitis, etc. Inhibit the bone marrow caused by neutropenia, or even aplastic anemia, such as the timely withdrawal is more recoverable and therefore should be ground check blood, no effect by 1 week, should not be reused. And double coumarin anticoagulants, sulfonamides, tolbutamide hypoglycemic drugs, increase the plasma concentration, toxicity increases. Sodium, chlorine retention effect, hypertension, edema, heart failure patients cannot use it and limit salt intake during the treatment. Patients with weak liver, osteoporosis, and kidney as well as drug allergy history are contraindicated or appropriate caution.

Preparation

Cyclization reaction of hydrogenated azobenzene and diethylmalonic acid diethyl: hydrazobenzene, butyl diethyl malonate, sodium sulfite and methanol are heated with severe reflux 1.5h, born in Bute salt, acidified with acetic acid to give Bute.

Acute toxicity

oral-rat LD50: 245 mg/kg; Oral-Mouse LD50: 270 mg/kg
Irritation Data: Eye – rabbit, 100 mg, moderate

Flammability hazard properties

thermal decomposition emitted poisonous nitrogen oxides fumes

Storage characteristics

Treasury ventilation low-temperature drying; and food raw materials stored separately

Extinguishing agent

Water, carbon dioxide, dry powder, foam

References

https://en.wikipedia.org/wiki/Phenylbutazone
https://pubchem.ncbi.nlm.nih.gov/compound/phenylbutazone#section=Top
http://www.medicinenet.com/phenylbutazone/article.htm

Description

Phenylbutazone, one of the earliest NSAIDs introduced, is now indicated for the symptomatic relief of rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, gout, and acute superficial thrombophlebitis. The gastrointestinal and bone marrow toxicity observed in its early use have been greatly reduced by lower dosage (300 mg/d). Nevertheless, it is used primarily where other drugs have failed and then only for short-term therapy. The drug has a long serum half-life of about 100 h. It is a moderately active cyclooxygenase inhibitor and it suppresses both spontaneous and chemotactic motility of neutrophils. In addition to the serious gastrointestinal and hematological adverse effects, sodium and water retention, rash, vertigo, and dermatitis are observed.

Chemical Properties

Off-Whtie Solid

Originator

Butazolidin, Geigy ,US,1952

Uses

A non-steroidal anti-inflammatory compound. An inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase

Uses

For the treatment of backache and ankylosing spondylitis

Uses

An inhibitor of Cox.

Uses

Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively.

Definition

ChEBI: Phenylbutazone is a member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position. It has a role as a non-narcotic analgesic, a non-steroidal anti-inflammatory drug, an antirheumatic drug, a peripheral nervous system drug, a metabolite and an EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor.

Manufacturing Process

7.6 parts of sodium are dissolved in 190 parts by volume of absolute alcohol; 65 parts of diethyl-n-butyl malonate and 65 parts of hydrazobenzene are added. The alcohol is slowly distilled off and the reaction mixture heated for 12 hours at a bath temperature of 150°C and finally in vacuo, until no more alcohol comes off.
The product is dissolved in water, clarified with a little animal charcoal and 15% hydrochloric acid is slowly added until an acid reaction to Congo red paper is produced. 1,2-Diphenyl-3,5-dioxo-4-n-butyl-pyrazolidine separates as an oil, which rapidly become crystalline. It crystallizes from alcohol as colorless needles with a MP of 105°C.

brand name

Azolid (Sanofi Aventis); Butazolidin (Novartis);Algesin;Algirreudin;Algoverine;Alka butazolidin;Alkabutazone;Alka-phenylbutazone;Alka-sterazolidin;Anarthral;Apophenylbutazone;Apo-phenylbutazone;Arteopan;Arthirikin;Artibrin;Artrisin;Artrodesmol extra;Bizolin 20;Bizolin 700;Butacal;Butacol;Butadilat;Butadin;Butadyne;Butafenil;Butagros;Butakvertin;Butaparin;Butaphen;Buta-phen;Butarex;Butartiril;Butatril;Butazolidin alka;Butazolidina;Butial;Butinol;Butiwas;Buto beta;Butoroid cream;Butrex;Carudol;Celestalgon;Celestazone;Colfezone;Corbuvit;Dartranol;Debutazon;Delta-butazolidin;Delta-demoplas;Delta-myogit;Delta-tomanol;Deltawaukobuzon;Dephimixn;Dexa tomanol;Dexa-attritin;Dexa-escopyrin;Dexamed;Dexatrzona;Dibuzon;Direstop;Ditrone;Doctofril;Dolosin dexa;Dolpirina;Ectobutazone;Ethibute;Exraheudon;Exrheudon;F 650;Fenibutina;Flebosil;Glycyl;Hepabuzon;Inflazone;Intrabuzone;Mammyl;Megazone;Mepha-butazone;Mepropyrin;Mi 540;Naupax;Neuro-demoplas;Neuzoline m;Novobutazone;Oluprin;Oppazoen;Osadrinim;Parazolidin;Parzolidon;Pasirheuman;Penetradol;Phenbuff;Phenbutazone;Phenylarthrite;Phenylbetazone;Phenylon plus;Phlebolan;Pirabutil;Pirarreumol-b;Pirarreumol-p;Prebutex;Precirhemin;Prednirheumin;Proxyfezone;Proydynam;Pyrbutal;Ranocor;Reopin;Reumilene;Rheopyrin;Rheosolon;Rheumanoln;Rheumaphen;Rheumycalm;Salzone;Servizolidin;Sigma-elmedal;Sintobutina;Stabilat;Tevocodyn;Tibutazone;Ticinil calcio;Ticinil calico;Trabit;Zolapelin;Zolidinium.

Therapeutic Function

Antiinflammatory, Antiarthritic

World Health Organization (WHO)

Phenylbutazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1949 for the treatment of rheumatic disorders. Its use was subsequently associated with serious and sometimes fatal adverse reactions, notably cases of aplastic anaemia and agranulocytosis. Many national drug regulatory authorities consider that more recently introduced drugs offer a safer alternative for most, if not all, patients requiring anti-inflammatory agents. Phenylbutazone has thus been either withdrawn at the national level or retained with rigorously restricted indications for patients unresponsive to other therapy. These restrictions also apply, in general, to combination products containing phenylbutazone.

General Description

Odorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2.

Air & Water Reactions

Phenylbutazone is relatively stable at ambient temperatures. Aqueous decomposition of Phenylbutazone occurs by hydrolysis and oxidation. Insoluble in water.

Reactivity Profile

Phenylbutazone is incompatible with strong oxidizers, strong acids and strong bases. .

Fire Hazard

Flash point data for Phenylbutazone are not available; however, Phenylbutazone is probably combustible.

Biochem/physiol Actions

Phenylbutazone is a hepatotoxin and binds to plasma proteins. It is used to treat inflammation in horse. Phenylbutazone has potential to treat ankylosing spondylitis. It has therapeutic potential to treat myotonic dystrophy type 1 (DM1) by inducing muscle blind-like protein 1 (MBNL1) expression. It also favors the expression of muscle chloride channel in skeletal muscles.

Clinical Use

Phenylbutazone is a nonsteroidal anti-inflammatory drug used for the acute treatment of ankylosing spondylitis, chronic polyarthritis, and gout. Because of severe side effects including disturbances of the hematopoietic system like agranulocytosis and aplastic anemia the use is limited to conditions in which other nonsteroidal antiinflammatory drugs do not show sufficient efficacy. Phenylbutazone is given as oral, rectal, intramuscular or topical formulation (up to 600 mg/d initial dose, up to 400 mg/d maintenance dose). The peak plasma concentration is reached 2 h after oral application. Phenylbutazone is bound to 98% to plasma protein. Oxyphenbutazone is formed as an active metabolite of phenylbutazone.

Safety Profile

Suspected human carcinogen producing leukemia. A human poison by parenteral route. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion and possibly other routes: fever, blood pressure increase, other unspecified vascular effects, damage to kidney tubules and glomeruli, decreased urine volume, blood in the urine, reduction in the number of whte blood cells, and agranulocytosis. Experimental teratogenic and reproductive effects. Human mutation data reported. An eye irritant. An antiinflammatory agent. When heated to decomposition it emits toxic fumes of NOx

Synthesis

Phenylbutazone, 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione (3.2.6), is synthesized in a single stage by reacting hydrazobenzol with butylmalonic ester [68,69].

Veterinary Drugs and Treatments

One manufacturer lists the following as the indications for phenylbutazone: “For the relief of inflammatory conditions associated with the musculoskeletal system in dogs and horses.” (Package Insert; Butazolidin?—Coopers). It has been used primarily for the treatment of lameness in horses and, occasionally, as an analgesic/ antiinflammatory, antipyretic in dogs, cattle, and swine.

Purification Methods

Crystallise the dione from EtOH. Its pK2 3 is 4.52 (in H2O), 4.89 (in 50% aqueous EtOH) and 5.25 (80% 2-methoxyethanol). It complexes with Hg2+, Cd2+ and Zn2+. It has UV with max at 239.5nm in MeOH+50% aqueous HClO4 and 264nm in aqueous 0.1N NaOH. [Beilstein 24 III/IV 1123.]

Phenylbutazone Preparation Products And Raw materials

Raw materials

Sodium sulfite 1,2-Diphenylhydrazine Diethyl butylmalonate Sodium ethoxide Sodium Methoxide Phenylbutazone sodium Diethyl malonate 1-Butanol

Preparation Products

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Hebei Ganmiao New material Technology Co., LTD

Product: Phenylbutazone 50-33-9
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Purity: 99.9%
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Hebei Duling International Trade Co. LTD

Product: Phenylbutazone 50-33-9
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Hebei Guanlang Biotechnology Co., Ltd.

Product: Phenylbutazone 50-33-9
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Release date: 2021-05-18

50-33-9, PhenylbutazoneRelated Search:

Triphenylphosphine Linezolid 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Cyhalofop-butyl Dibutyl phthalate Buprofezin Laurocapram Biphenyl BUTYL OLEATE Pyraclostrobin tert-Butylchlorodiphenylsilane Zolpidem tartrate Phenylacetone (+/-)-Sulfinpyrazone Zolpidem PHENYLBUTAZONE SODIUM Lactobionic acid OXYPHENBUTAZONE HYDRATE

PHENYLBUTAZONE

1,2-Diphenyl-2,3-dioxo-4-N-butylpyrazoline

1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine

1,2-Diphenyl-4-butyl-3,5-dioxopyrazolidine

1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione

Benzone

Betazed

bizolin

Bizolin 200

bizolin200

Bunetzone

Busone

Buta phen

Butacompren

Butacote

Butadion

Butadiona

Butadione

Butagesic

Butalan

Butalgina

Butalidon

Butaluy

Butapirazol

Butapirazole

Butapyrazole

Butarecbon

Butartril

Butartrina

Butazina

Butazolidin

Butazolidine

Butazona

Butazone

Bute

Butidiona

Butiwas-Simple

Butone

Butoz

Butylpyrin

Buvetzone

Buzon

Chembutazone

component of Azolid-A

DA-192

g13871

Ia-But

Intalbut

Intrabutazone

Intrazone

Ipsoflame

Kadol

Lingel

Malgesic

Mephabutazon

Mephabutazone

Merizone

Nadazone