ChemicalBook > CAS DataBase List > 4,5-DIMETHOXY-1-INDANONE

4,5-DIMETHOXY-1-INDANONE

Product Name: 4,5-DIMETHOXY-1-INDANONE
CAS No.: 6342-80-9
Chemical Name: 4,5-DIMETHOXY-1-INDANONE
Synonyms: 4,5-DIMETHOXY-1-INDANONE;4,5-DIMETHOXY-INDAN-1-ONE;4,5-Dimethoxy-1-indanone 97%;4,5-dimethoxy-2,3-dihydroinden-1-one;2,3-dihydro-4,5-dimethoxy-1H-Inden-1-one;4,5-DiMethoxy-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-4,5-diMethoxy-
CBNumber: CB0375427
Molecular Formula: C11H12O3
Formula Weight: 192.21
MOL File: 6342-80-9.mol

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4,5-DIMETHOXY-1-INDANONE Property

Melting point:: 73-77 °C (lit.)
Boiling point:: 160-161 °C(Press: 2 Torr)
Density: 1.179±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
Appearance: Off-white to yellow Solid

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 568252
Product name: 4,5-Dimethoxy-1-indanone
Purity: 97%
Packaging: 1g
Price: $68.4
Updated: 2023/06/20

TRC

Product number: D470525
Product name: 4,5-Dimethoxy-1-indanone
Packaging: 1g
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD147244
Product name: 4,5-Dimethoxy-1-indanone
Packaging: 1g
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: 9667AB
Product name: 4,5-Dimethoxy-2,3-dihydro-1H-inden-1-one
Packaging: 250mg
Price: $186
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD147244
Product name: 4,5-Dimethoxy-1-indanone
Packaging: 2g
Price: $280
Updated: 2021/12/16

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4,5-DIMETHOXY-1-INDANONE Chemical Properties,Usage,Production

Uses

4,5-Dimethoxy-1-indanone acts as a reagent for the preparation of thiosemicarbazones derived from 1-indanone as new anti-trypanosoma cruzi agents.

Definition

ChEBI: 4,5-dimethoxy-2,3-dihydroinden-1-one is a member of indanones.

Synthesis

10538-48-4

6342-80-9

3-(2,3-dimethoxyphenyl)propionic acid (4.99 g, 23.7 mmol) was mixed with Eaton's reagent (47.5 mL, 3 g/mmol of raw material) and stirred at room temperature for 72 hours. Upon completion of the reaction, the mixture was slowly poured into ice water, neutralized to neutral, and subsequently extracted with ethyl acetate (3 x 75 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography using a pre-packed 100 g silica gel column [eluent A: ethyl acetate; eluent B: n-hexane; gradient elution: 7% A/93% B (1 column volume), 7% A/93% B→60% A/40% B (10 column volumes), 60% A/40% B (2 column volumes); flow rate: 40 mL/min; detection wavelengths: 254 nm and 280 nm] to give 4,5-dimethoxy-1-indanone (2.01 g, 10.5 mmol, 44% yield) as a yellow solid.1H NMR (CDCl3, 600 MHz) δ 7.06 (1H, d, J = 8.4 Hz), 6.62 (1H, d, J = 8.4 Hz), 3.61 (3H, s), 3.57 (3H, s), 2.70 (2.70 (2.70), 2.70 (2.70), 2.70 (2.70), 2.70 (3H, s), 2.70 (3H, s). s), 2.70 (2H, t, J = 5.4 Hz), 2.25 (2H, t, J = 5.4 Hz).13C NMR (CDCl3, 150 MHz) δ 204.6, 157.1, 147.4, 145.0, 130.7, 119.4, 112.0, 59.8, 55.8, 36.0, 22.1.

References

[1] Canadian Journal of Chemistry, 1982, vol. 60, # 21, p. 2678 - 2686
[2] Synthetic Communications, 2001, vol. 31, # 13, p. 2029 - 2036
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 9, p. 3331 - 3347
[4] Journal of Medicinal Chemistry, 1987, vol. 30, # 8, p. 1303 - 1308
[5] Journal of Organic Chemistry, 1984, vol. 49, # 12, p. 2130 - 2135

4,5-DIMETHOXY-1-INDANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,5-DIMETHOXY-1-INDANONE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,5-DIMETHOXY-1-INDANONE 6342-80-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Career Henan Chemical Co

Product: 4,5-DIMETHOXY-1-INDANONE 6342-80-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99.99%
Supply Ability: 1kg-10MT
Release date: 2019-05-24

6342-80-9, 4,5-DIMETHOXY-1-INDANONERelated Search:

4-METHOXY-1-INDANONE Indan 1-Indanone 5,6-Dimethoxy-1-indanone 98%,5,6-DIMETHOXY-1-INDANONE,98%,5,6-DIMETHOXY-1-INDANONE,Donepezil5,6Dimethoxy-1-Indanone 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE Ethyl 2,3-dihydro-5,6-dimethoxy-1-oxo-1H-indene-2-carboxylate 4,5-DIMETHOXY-1-INDANONE 4-Hydroxyindan-1-one 5-INDANOL 5-Hydroxy-1-indanone 5-Methoxy-1-indanone 5-METHOXYINDAN 4,5,6-TRIMETHOXY-INDANONE 3-(2,3-DIMETHOXY-PHENYL)-PROPIONALDEHYDE 4,5-DIMETHOXY-2-METHYL-INDAN-1-ONE 6,7-DIMETHOXY-1-INDANONE 4 7-DIMETHOXY-1-INDANONE 97 2-(2-bromo-4,5-dimethoxyphenyl)-3-(4-bromophenyl)-5,6-dimethoxy-1-indanone

4,5-DIMETHOXY-1-INDANONE

4,5-DIMETHOXY-INDAN-1-ONE

1H-Inden-1-one, 2,3-dihydro-4,5-diMethoxy-

4,5-DiMethoxy-2,3-dihydro-1H-inden-1-one

4,5-Dimethoxy-1-indanone 97%

2,3-dihydro-4,5-dimethoxy-1H-Inden-1-one

4,5-dimethoxy-2,3-dihydroinden-1-one

6342-80-9

C11 to C12

Carbonyl Compounds

Building Blocks

Organic Building Blocks

Ketones

C11 to C12

Carbonyl Compounds

Ketones