4-Hydroxyindan-1-one
- Product Name
- 4-Hydroxyindan-1-one
- CAS No.
- 40731-98-4
- Chemical Name
- 4-Hydroxyindan-1-one
- Synonyms
- 4-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-ONE;4-HYDROXYINDANONE;4-HYDROXY-1-INDANONE;4-HYDROXY-INDAN-1-ONE;Hydroxyindanone;4-HYDROXYINDANONE 98+%;4-Hydroxy-1-indanone>4-Hydroxy-1-indanone,97%;2,3-dihydro-4-hydroxyinden-1-one;4-hydroxy-2,3-dihydroinden-1-one
- CBNumber
- CB6271341
- Molecular Formula
- C9H8O2
- Formula Weight
- 148.16
- MOL File
- 40731-98-4.mol
4-Hydroxyindan-1-one Property
- Melting point:
- 242-244 °C (lit.)
- Boiling point:
- 307.6±31.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in ethanol. (25mg/ml)
- form
- powder to crystal
- pka
- 9.22±0.20(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C9H8O2/c10-8-3-1-2-6-7(8)4-5-9(6)11/h1-3,10H,4-5H2
- InChIKey
- CKSCMRNFDBWFND-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C(O)=CC=C2)CC1
- CAS DataBase Reference
- 40731-98-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 389234
- Product name
- 4-Hydroxy-1-indanone
- Purity
- ≤3% solvents of recrystallization., 97%
- Packaging
- 5g
- Price
- $108
- Updated
- 2023/06/20
- Product number
- H0723
- Product name
- 4-Hydroxy-1-indanone
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $633
- Updated
- 2025/07/31
- Product number
- H0723
- Product name
- 4-Hydroxy-1-indanone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $3147
- Updated
- 2025/07/31
- Product number
- H953618
- Product name
- 4-Hydroxy-1-indanone
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR18351
- Product name
- 4-Hydroxyindan-1-one
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
4-Hydroxyindan-1-one Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Hydroxy-1-indanone is a hydroxylated indanone used for synthesis. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.
Synthesis
119-84-6
40731-98-4
General procedure for the synthesis of 4-hydroxy-1-indanone from hydrogenated cinnamic acid lactone: A mixture of aluminum chloride (90.0 g, 676 mmol) and sodium chloride was stirred at 150 °C until the solid was completely dissolved, followed by the slow dropwise addition of hydrogenated cinnamic acid lactone (20.0 g, 135 mmol). After the dropwise addition, the reaction mixture was warmed to 200 °C and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water (500 mL), followed by filtration to collect the crude product. The crude product was purified by recrystallization to afford 4-hydroxy-1-indanone (19 g, 95% yield) as a gray solid. The structure of the compound was confirmed by the following spectral data: mass spectrum (ESI positive ion mode) m/z 149.5 [M + H]+; 1H NMR (400 MHz, CDCl3) δ (ppm): 7.41-7.38 (m, 1H), 7.24-7.19 (m, 1H), 6.80-6.79 (m, 1H), 6.78-6.77 (d , 1H, J = 4.0 Hz), 5.46 (br, 1H), 3.06-3.03 (m, 2H), 2.69-2.66 (m, 2H).
References
[1] Patent: WO2014/19344, 2014, A1. Location in patent: Paragraph 00820
[2] Patent: WO2014/82380, 2014, A1. Location in patent: Paragraph 00314; 00315
[3] Patent: WO2014/82379, 2014, A1. Location in patent: Page/Page column 112; 113
[4] Patent: WO2014/131315, 2014, A1. Location in patent: Page/Page column 112
[5] Patent: US2015/79028, 2015, A1. Location in patent: Paragraph 2389; 2390; 2391; 2392; 2393
4-Hydroxyindan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxyindan-1-one manufacturers
- Product
- 4-Hydroxyindan-1-one 40731-98-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-27
- Product
- 4-Hydroxyindan-1-one 40731-98-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-31