6-Hydroxy-1-indanone
- Product Name
- 6-Hydroxy-1-indanone
- CAS No.
- 62803-47-8
- Chemical Name
- 6-Hydroxy-1-indanone
- Synonyms
- 6-Hydroxy-2,3-dihydro-1H-inden-1-one;6-Hydroxy-1-Indenone;6-Hydroxyindan-1-one;6-HYDROXY-1-INDANONE;6-Hydroxy-1-indanone>6-Hydroxyindan-1-one 98%;6-HYDROXY-1-INDANONE 99%;6-hydroxy-2,3-dihydroinden-1-one;2,3-Dihydro-6-hydroxy-1H-inden-1-one;6-Hydrocy-2,3-Dihydro-1H-Inden-1-One
- CBNumber
- CB4747239
- Molecular Formula
- C9H8O2
- Formula Weight
- 148.16
- MOL File
- 62803-47-8.mol
6-Hydroxy-1-indanone Property
- Melting point:
- 154-158 °C (lit.)
- Boiling point:
- 329.0±31.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 9.45±0.20(Predicted)
- color
- Light yellow to Amber to Dark green
- InChIKey
- MOANRQDXNNXOLW-UHFFFAOYSA-N
- CAS DataBase Reference
- 62803-47-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 2
- HS Code
- 29145090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 634549
- Product name
- 6-Hydroxy-1-indanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $153
- Updated
- 2023/06/20
- Product number
- H1310
- Product name
- 6-Hydroxy-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- H1310
- Product name
- 6-Hydroxy-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $190
- Updated
- 2025/07/31
- Product number
- H953828
- Product name
- 6-Hydroxy-1-indanone
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- JK462272
- Product name
- 6-Hydroxy-1-indanone
- Purity
- 98%
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
6-Hydroxy-1-indanone Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
6-Hydroxy-1-indanone can be used in the synthesis of tetracyclic ketones intermediates during the total syntheses of (±)-frondosin C and (±)-8-epi-frondosin C. It can also be used in the synthesis of 1,4-dihydroindeno[1,2-c]pyrazoles, which can act like potent CHK-1 inhibitors, thereby inhibiting the growth of cancer cells.
Synthesis
13623-25-1
62803-47-8
6-Methoxy-1-indanone (2.5 g, 15.4 mmol) was slowly added to a stirred suspension of aluminum chloride (5.3 g, 39.7 mmol) in toluene (75 mL) at room temperature and under nitrogen protection. The 6-methoxy-1-indanone remaining in the powder addition funnel was flushed into the reaction mixture using toluene (25 mL). The reaction mixture was heated to reflux and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. The mixture was transferred to a dispensing funnel using ethyl acetate. The organic and aqueous layers were separated and the organic phase was sequentially washed twice with water and once with saturated sodium chloride solution, followed by drying with anhydrous magnesium sulfate. The dried organic phase was filtered and the filtrate was concentrated to give 1.5 g (66% yield) of 6-hydroxy-2,3-dihydro-1H-inden-1-one, the product was a light tan solid.1H NMR (400 MHz, DMSO-d6) δ: 9.72 (s, 1H), 7.36 (d, J = 8 Hz, 1H), 7.07 (dd, J = 8, 3 Hz, 1H) , 6.90 (d, J = 3 Hz, 1H), 2.94 (m, 2H), 2.58 (m, 2H).ESI-MS m/z: 149 ([M + H]+).
References
[1] Organic Preparations and Procedures International, 2009, vol. 41, # 4, p. 309 - 314
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 7, p. 1068 - 1083
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 20, p. 5665 - 5670
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 6, p. 1675 - 1678
[5] Chemical Communications, 2011, vol. 47, # 22, p. 6290 - 6292
6-Hydroxy-1-indanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Hydroxy-1-indanone manufacturers
- Product
- 6-Hydroxy-1-indanone 62803-47-8
- Price
- US $0.00-0.00/kG
- Min. Order
- 1kG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2025-09-24
- Product
- 6-Hydroxy-1-indanone 62803-47-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 6-Hydroxy-1-indanone 62803-47-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11