6-Methoxy-1H-indanone
- Product Name
- 6-Methoxy-1H-indanone
- CAS No.
- 13623-25-1
- Chemical Name
- 6-Methoxy-1H-indanone
- Synonyms
- NSC 338231;6-METHOXY INDANONE;6-Methoxy-1-indenone;6-Methoxy-I-indanone;6-METHOXY-1-INDANONE;6-METHOXY-1H-INDANONE;6-METHOXY-INDAN-1-ONE;6-Methoxyindane-1-one;6-Methoxyl-1-indanone;2,3-Dihydro-6-Methoxy-
- CBNumber
- CB2171298
- Molecular Formula
- C10H10O2
- Formula Weight
- 162.19
- MOL File
- 13623-25-1.mol
6-Methoxy-1H-indanone Property
- Melting point:
- 105-109 °C (lit.)
- Boiling point:
- 228.88°C (rough estimate)
- Density
- 1.0281 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Fine Crystalline Powder
- color
- White to yellow
- BRN
- 1238602
- InChI
- InChI=1S/C10H10O2/c1-12-8-4-2-7-3-5-10(11)9(7)6-8/h2,4,6H,3,5H2,1H3
- InChIKey
- UJGDLLGKMWVCPT-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC(OC)=C2)CC1
- CAS DataBase Reference
- 13623-25-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25-36/37-36-26
- WGK Germany
- 3
- HS Code
- 29145090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 175250
- Product name
- 6-Methoxy-1-indanone
- Purity
- ≥97%
- Packaging
- 5g
- Price
- $38.6
- Updated
- 2023/01/07
- Product number
- M1535
- Product name
- 6-Methoxy-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- M1535
- Product name
- 6-Methoxy-1-indanone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- M262695
- Product name
- 6-Methoxy-1-indanone
- Packaging
- 100g
- Price
- $990
- Updated
- 2021/12/16
- Product number
- JK191795
- Product name
- 6-Methoxy-1-indanone
- Purity
- 98%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
6-Methoxy-1H-indanone Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
Indanone derivative as a1-adrenoceptor antagonist.
Uses
6-Methoxy-1-indanone was used in the synthesis of 5-methoxyninhydrin (2,2-dihydroxy-5-methoxy-1,3-indanedione).
Uses
Indanone derivative as α1-adrenoceptor antagonist.
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 1092, 1949 DOI: 10.1021/ja01171a092
Synthesis
1929-29-9
13623-25-1
General procedure for the synthesis of 6-methoxy-1-indanone from 3-(4-methoxyphenyl)propionic acid: trifluoromethanesulfonic acid (3 eq.) was slowly added to a solution of 3-(4-methoxyphenyl)propionic acid (0.5 mmol) dissolved in anhydrous CH2Cl2 (1.0 mL) in a 12 mL Q-tube?pressure tube (provided by QLabtech). The reaction mixture was then warmed to room temperature. A PTFE septum was placed on top of the reaction tube and sealed with the appropriate cap and pressure adapter. The sealed reaction tube was heated in an oil bath at 80°C. The reaction process was monitored by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS) until the feedstock completely disappeared. After completion of the reaction, the mixture was poured into ice water and extracted three times with CH2Cl2. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. Finally, the target compound 6-methoxy-1-indanone was purified from the crude product by fast column chromatography.
Purification Methods
Crystallise it from MeOH, then sublime it at high vacuum. [Beilstein 8 IV 894.]
References
[1] Molecules, 2014, vol. 19, # 5, p. 5599 - 5610
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 5, p. 470 - 475
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 35, p. 7374 - 7379
[4] Synthetic Communications, 1991, vol. 21, # 21, p. 2231 - 2256
[5] Tetrahedron Letters, 2004, vol. 45, # 8, p. 1741 - 1745
6-Methoxy-1H-indanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methoxy-1H-indanone manufacturers
- Product
- 6-Methoxy-1H-indanone 13623-25-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-02
- Product
- 6-Methoxy-1H-indanone 13623-25-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- 6-Methoxy-1H-Indanone 13623-25-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 200kgs/month
- Release date
- 2021-11-14