Synthesis
ChemicalBook > CAS DataBase List > 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

Synthesis
Product Name
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
CAS No.
120014-07-5
Chemical Name
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
Synonyms
Donepezil-013;Donepezil-013-Z;Dehydro Donepezi;Dehydro Donepezil;Donepezil USP RC A;Donepezil Impurity O;Donepezil Impurity 17;Donepezil related compound;1-Benzyl-4-(5,6-dimethoxy-1-ox;2-[(1-Benzylpiperidin-4-yl)methylen
CBNumber
CB3854945
Molecular Formula
C24H27NO3
Formula Weight
377.48
MOL File
120014-07-5.mol
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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Property

Melting point:
176-178°C
Boiling point:
542.8±50.0 °C(Predicted)
Density 
1.209±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
8.03±0.10(Predicted)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
J11663
Product name
Donepezilrelatedcompound(E/Zmixture)
Packaging
100mg
Price
$49
Updated
2021/12/16
Oakwood
Product number
036506
Product name
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
Purity
97%
Packaging
1g
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
IB18353
Product name
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
IB18353
Product name
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
Packaging
250mg
Price
$100
Updated
2021/12/16
Apolloscientific
Product number
OR61173
Product name
2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one
Purity
97%
Packaging
5g
Price
$137
Updated
2021/12/16
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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Chemical Properties,Usage,Production

Synthesis

A solution of 5,6-dimethoxy-indanone (19 g, 0.10 mol) in methanol (8 mL) is stirred under inert atmosphere at room temperature. Slowly add NaOH flakes (12.8 g, 0.32 mol) followed by N-benzyl-piperidine-4-carboxaldehyde (20.2 g, 0.10 mol) to the reaction mixture. The mixture was stirred at room temperature for 3 h and progress of the reaction was monitored by TLC (hexane:ethyl acetate; 1:1). Once the reaction is complete, the solid formed was filtered, washed with 5 % acetic acid and then with methanol and dried. The obtained solid (34 g) was taken into a round bottom flask and refluxed with DMF (50 mL). Gradually cooled to room temperature and stirred for 2 h, filtered the solid formed, wash with chilled methanol to afford a pale yellow crystalline solid 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine (32.0 g, 84 %); m.p.: 175-177 °C.

Uses

An impurity of Donepezil; an intermediate as an anti-Alzheimer agent.

Uses

An impurity of Donepezil (D531750); an intermediate as an anti-Alzheimer's agent.

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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ShangHai DEMO Chemical Co.,Ltd
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400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
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China
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Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
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United States
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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China
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Chemsky(shanghai)International Co.,Ltd.
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China
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XiaoGan ShenYuan ChemPharm co,ltd
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15527768850
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1791901229@qq.com
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China
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Beijing Isomersyn Technology CO;LTD
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010-82954736 13391601435
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sales@isomersyn.com
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China
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3295
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Hangzhou Yuhao Chemical Technology Co., Ltd
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0571-82693216
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+86-571-82880190
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info@yuhaochemical.com
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China
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View Lastest Price from 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine manufacturers

Career Henan Chemical Co
Product
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 120014-07-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

120014-07-5, 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidineRelated Search:


  • 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97%
  • 1-Benzyl-4-(5,6-dimethoxy-1-ox
  • 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE
  • 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
  • 2-(1-Benzylpiperidin-4-ylmethylidene)-5,6-dimethoxyindan-1-one
  • 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one
  • Dehydro Donepezil (Donepezil Impurity)
  • 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one
  • 1-Benzyl-4-[(5,6-diMethoxy-1-oxoindan-2-ylidene)Methyl]piperidine (Donepezil IMpurity)
  • 1-Benzyl-4-(5,6-diMethoxy-1-oxoindan-2-ylindeneMet
  • Dehydro Donepezi
  • Donepezil USP RC A
  • 1-Benzyl-4-[(1,3-dihydro-5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]piperidine
  • 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one
  • Donepezil related coMpound (E/Z Mixture)
  • 1H-Inden-1-one, 2,3-dihydro- 5,6-diMethoxy-2-[[1-( phenylMethyl)-4-piperidinyl] Methylene]-
  • (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  • Dehydro Donepezil
  • Donepezil-013
  • Donepezil impurity 16/1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • Donepezil related compound
  • 1-benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • 2-[(1-benzyl-4-piperidyl)methyleen]-5,6-dimethoxyindan-1-on
  • 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  • Donepezil Impurity O
  • Donepezil-013-Z
  • Donepezil Impurity 17
  • 2-[(1-Benzylpiperidin-4-yl)methylen
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine DISCONTINUED. Please see D229775
  • 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperi...
  • Donepezil Dehydro Impurity (E/Z mixture)
  • 2-[(1-Benzylpiperidin-4-yl)methylene]-2,3-dihydro-5,6-dimethoxyinden-1-one
  • (E)-1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • 120014-07-5
  • C24H27NO3
  • Aromatics
  • Heterocycles
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals