6-Methoxy-1H-indanone

Product Name: 6-Methoxy-1H-indanone
CAS No.: 13623-25-1
Chemical Name: 6-Methoxy-1H-indanone
Synonyms: NSC 338231;6-METHOXY INDANONE;6-Methoxy-1-indenone;6-Methoxy-I-indanone;6-METHOXY-1-INDANONE;6-METHOXY-1H-INDANONE;6-METHOXY-INDAN-1-ONE;6-Methoxyindane-1-one;6-Methoxyl-1-indanone;2,3-Dihydro-6-Methoxy-
CBNumber: CB2171298
Molecular Formula: C10H10O2
Formula Weight: 162.19
MOL File: 13623-25-1.mol

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6-Methoxy-1H-indanone Property

Melting point:: 105-109 °C (lit.)
Boiling point:: 228.88°C (rough estimate)
Density: 1.0281 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: Fine Crystalline Powder
color: White to yellow
BRN: 1238602
InChI: InChI=1S/C10H10O2/c1-12-8-4-2-7-3-5-10(11)9(7)6-8/h2,4,6H,3,5H2,1H3
InChIKey: UJGDLLGKMWVCPT-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC(OC)=C2)CC1
CAS DataBase Reference: 13623-25-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36/37-36-26
WGK Germany: 3
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 175250
Product name: 6-Methoxy-1-indanone
Purity: ≥97%
Packaging: 5g
Price: $38.6
Updated: 2023/01/07

TCI Chemical

Product number: M1535
Product name: 6-Methoxy-1-indanone
Purity: >98.0%(GC)
Packaging: 5g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: M1535
Product name: 6-Methoxy-1-indanone
Purity: >98.0%(GC)
Packaging: 25g
Price: $96
Updated: 2025/07/31

TRC

Product number: M262695
Product name: 6-Methoxy-1-indanone
Packaging: 100g
Price: $990
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK191795
Product name: 6-Methoxy-1-indanone
Purity: 98%
Packaging: 1g
Price: $35
Updated: 2021/12/16

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6-Methoxy-1H-indanone Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Indanone derivative as a1-adrenoceptor antagonist.

Uses

6-Methoxy-1-indanone was used in the synthesis of 5-methoxyninhydrin (2,2-dihydroxy-5-methoxy-1,3-indanedione).

Uses

Indanone derivative as α1-adrenoceptor antagonist.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 1092, 1949 DOI: 10.1021/ja01171a092

Synthesis

1929-29-9

13623-25-1

General procedure for the synthesis of 6-methoxy-1-indanone from 3-(4-methoxyphenyl)propionic acid: trifluoromethanesulfonic acid (3 eq.) was slowly added to a solution of 3-(4-methoxyphenyl)propionic acid (0.5 mmol) dissolved in anhydrous CH2Cl2 (1.0 mL) in a 12 mL Q-tube?pressure tube (provided by QLabtech). The reaction mixture was then warmed to room temperature. A PTFE septum was placed on top of the reaction tube and sealed with the appropriate cap and pressure adapter. The sealed reaction tube was heated in an oil bath at 80°C. The reaction process was monitored by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS) until the feedstock completely disappeared. After completion of the reaction, the mixture was poured into ice water and extracted three times with CH2Cl2. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. Finally, the target compound 6-methoxy-1-indanone was purified from the crude product by fast column chromatography.

Purification Methods

Crystallise it from MeOH, then sublime it at high vacuum. [Beilstein 8 IV 894.]

References

[1] Molecules, 2014, vol. 19, # 5, p. 5599 - 5610
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 5, p. 470 - 475
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 35, p. 7374 - 7379
[4] Synthetic Communications, 1991, vol. 21, # 21, p. 2231 - 2256
[5] Tetrahedron Letters, 2004, vol. 45, # 8, p. 1741 - 1745

6-Methoxy-1H-indanone Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Methoxy-1H-indanone Suppliers

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View Lastest Price from 6-Methoxy-1H-indanone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Methoxy-1H-indanone 13623-25-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-02

Henan Aochuang Chemical Co.,Ltd.

Product: 6-Methoxy-1H-indanone 13623-25-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Shanghai Rlavie Technology Co ltd

Product: 6-Methoxy-1H-Indanone 13623-25-1
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 200kgs/month
Release date: 2021-11-14

13623-25-1, 6-Methoxy-1H-indanoneRelated Search:

DONEPEZIL HYDROCHLORIDE Donepezil 6-Methoxy-1H-indanone 4-METHOXY-1-INDANONE 5-METHOXY-1-INDANONE-3-ACETIC ACID Flosulide 5,6-Dimethoxy-1-indanone 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 4,5-DIMETHOXY-1-INDANONE 5-Methoxy-1-indanone Ethyl 2,3-dihydro-5,6-dimethoxy-1-oxo-1H-indene-2-carboxylate 1-Indanone 2-BROMO-2,3-DIHYDRO-5,6-DIMETHOXY-1H-INDEN-1-ONE 4,5,6-TRIMETHOXY-INDANONE 4-Bromo-6,7-dimethoxyindanone 5-METHOXYNINHYDRIN MONOHYDRATE 1H-Indene-4-carboxylic acid, 2,3-dihydro-6,7-dimethoxy-1-oxo- 5,6-DIMETHOXY-2-((3-PHENOXYPHENYL)METHYLENE)INDAN-1-ONE

6-METHOXY-INDAN-1-ONE

6-METHOXY-1H-INDANONE

6-METHOXY-1-INDANONE

6-METHOXY-1-INDANONE, 97+%

6-Methoxy-I-indanone

6-Methoxy-1-indenone

6-METHOXY INDANONE

2,3-Dihydro-6-methoxy-1H-inden-1-one

6-Methoxyindane-1-one

NSC 338231

6-Methoxy-2,3-dihydro-1H-indene-1-one

6-Methoxy-1-indanone,98%

6-Methoxy-2,3-dihydroinden-1-one

6-Methoxy-2,3-dihydro-1H-inden-1-one

6-Methoxy-1-indanone, 98% 1GR

2,3-Dihydro-6-Methoxy-

6-Methoxyl-1-indanone

2,3-Dihydro-6-Methoxyinden-1-one

6-Methoxy-1-indanone&gt

1H-Inden-1-one, 2,3-dihydro-6-methoxy-

6-Methoxy-1-indanone, 96% (Custom work)

Toltrazuril Impurity 1-d3

13623-25-1

Ketones

Organic Building Blocks

KETONE

Building Blocks

Carbonyl Compounds

C10

Indane/Indanone and Derivatives

indanone

Aromatics Compounds

Aromatics

C10

Carbonyl Compounds

Ketones