ChemicalBook > CAS DataBase List > 6-Methoxy-1H-indanone

6-Methoxy-1H-indanone

Product Name
6-Methoxy-1H-indanone
CAS No.
13623-25-1
Chemical Name
6-Methoxy-1H-indanone
Synonyms
NSC 338231;6-METHOXY INDANONE;6-Methoxy-1-indenone;6-Methoxy-I-indanone;6-METHOXY-1-INDANONE;6-METHOXY-1H-INDANONE;6-METHOXY-INDAN-1-ONE;6-Methoxyindane-1-one;6-Methoxyl-1-indanone;2,3-Dihydro-6-Methoxy-
CBNumber
CB2171298
Molecular Formula
C10H10O2
Formula Weight
162.19
MOL File
13623-25-1.mol
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6-Methoxy-1H-indanone Property

Melting point:
105-109 °C (lit.)
Boiling point:
228.88°C (rough estimate)
Density 
1.0281 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
Fine Crystalline Powder
color 
White to yellow
BRN 
1238602
InChI
InChI=1S/C10H10O2/c1-12-8-4-2-7-3-5-10(11)9(7)6-8/h2,4,6H,3,5H2,1H3
InChIKey
UJGDLLGKMWVCPT-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=CC(OC)=C2)CC1
CAS DataBase Reference
13623-25-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-36/37-36-26
WGK Germany 
3
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
175250
Product name
6-Methoxy-1-indanone
Purity
≥97%
Packaging
5g
Price
$38.6
Updated
2023/01/07
TCI Chemical
Product number
M1535
Product name
6-Methoxy-1-indanone
Purity
>98.0%(GC)
Packaging
5g
Price
$35
Updated
2025/07/31
TCI Chemical
Product number
M1535
Product name
6-Methoxy-1-indanone
Purity
>98.0%(GC)
Packaging
25g
Price
$96
Updated
2025/07/31
TRC
Product number
M262695
Product name
6-Methoxy-1-indanone
Packaging
100g
Price
$990
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11650
Product name
6-Methoxy-1-indanone
Packaging
12.5g
Price
$2000
Updated
2021/12/16
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6-Methoxy-1H-indanone Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Indanone derivative as a1-adrenoceptor antagonist.

Uses

6-Methoxy-1-indanone was used in the synthesis of 5-methoxyninhydrin (2,2-dihydroxy-5-methoxy-1,3-indanedione).

Uses

Indanone derivative as α1-adrenoceptor antagonist.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 1092, 1949 DOI: 10.1021/ja01171a092

Synthesis

1929-29-9

13623-25-1

General procedure for the synthesis of 6-methoxy-1-indanone from 3-(4-methoxyphenyl)propionic acid: trifluoromethanesulfonic acid (3 eq.) was slowly added to a solution of 3-(4-methoxyphenyl)propionic acid (0.5 mmol) dissolved in anhydrous CH2Cl2 (1.0 mL) in a 12 mL Q-tube?pressure tube (provided by QLabtech). The reaction mixture was then warmed to room temperature. A PTFE septum was placed on top of the reaction tube and sealed with the appropriate cap and pressure adapter. The sealed reaction tube was heated in an oil bath at 80°C. The reaction process was monitored by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC/MS) until the feedstock completely disappeared. After completion of the reaction, the mixture was poured into ice water and extracted three times with CH2Cl2. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. Finally, the target compound 6-methoxy-1-indanone was purified from the crude product by fast column chromatography.

Purification Methods

Crystallise it from MeOH, then sublime it at high vacuum. [Beilstein 8 IV 894.]

References

[1] Molecules, 2014, vol. 19, # 5, p. 5599 - 5610
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 5, p. 470 - 475
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 35, p. 7374 - 7379
[4] Synthetic Communications, 1991, vol. 21, # 21, p. 2231 - 2256
[5] Tetrahedron Letters, 2004, vol. 45, # 8, p. 1741 - 1745

6-Methoxy-1H-indanone Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Methoxy-1H-indanone Suppliers

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View Lastest Price from 6-Methoxy-1H-indanone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
6-Methoxy-1H-indanone 13623-25-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-02
Henan Aochuang Chemical Co.,Ltd.
Product
6-Methoxy-1H-indanone 13623-25-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Shanghai Rlavie Technology Co ltd
Product
6-Methoxy-1H-Indanone 13623-25-1
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%minHPLC
Supply Ability
200kgs/month
Release date
2021-11-14

13623-25-1, 6-Methoxy-1H-indanoneRelated Search:

DONEPEZIL HYDROCHLORIDE Donepezil 6-Methoxy-1H-indanone 4-METHOXY-1-INDANONE 5-METHOXY-1-INDANONE-3-ACETIC ACID Flosulide 5,6-Dimethoxy-1-indanone 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 4,5-DIMETHOXY-1-INDANONE 5-Methoxy-1-indanone Ethyl 2,3-dihydro-5,6-dimethoxy-1-oxo-1H-indene-2-carboxylate 1-Indanone 2-BROMO-2,3-DIHYDRO-5,6-DIMETHOXY-1H-INDEN-1-ONE 4,5,6-TRIMETHOXY-INDANONE 4-Bromo-6,7-dimethoxyindanone 5-METHOXYNINHYDRIN MONOHYDRATE 1H-Indene-4-carboxylic acid, 2,3-dihydro-6,7-dimethoxy-1-oxo- 5,6-DIMETHOXY-2-((3-PHENOXYPHENYL)METHYLENE)INDAN-1-ONE

  • 6-METHOXY-INDAN-1-ONE
  • 6-METHOXY-1H-INDANONE
  • 6-METHOXY-1-INDANONE
  • 6-METHOXY-1-INDANONE, 97+%
  • 6-Methoxy-I-indanone
  • 6-Methoxy-1-indenone
  • 6-METHOXY INDANONE
  • 2,3-Dihydro-6-methoxy-1H-inden-1-one
  • 6-Methoxyindane-1-one
  • NSC 338231
  • 6-Methoxy-2,3-dihydro-1H-indene-1-one
  • 6-Methoxy-1-indanone,98%
  • 6-Methoxy-2,3-dihydroinden-1-one
  • 6-Methoxy-2,3-dihydro-1H-inden-1-one
  • 6-Methoxy-1-indanone, 98% 1GR
  • 2,3-Dihydro-6-Methoxy-
  • 6-Methoxyl-1-indanone
  • 2,3-Dihydro-6-Methoxyinden-1-one
  • 6-Methoxy-1-indanone&gt
  • 1H-Inden-1-one, 2,3-dihydro-6-methoxy-
  • 6-Methoxy-1-indanone, 96% (Custom work)
  • Toltrazuril Impurity 1-d3
  • 13623-25-1
  • Ketones
  • Organic Building Blocks
  • KETONE
  • Building Blocks
  • Carbonyl Compounds
  • C10
  • Indane/Indanone and Derivatives
  • indanone
  • Aromatics Compounds
  • Aromatics
  • C10
  • Carbonyl Compounds
  • Ketones