Flosulide
- Product Name
- Flosulide
- CAS No.
- 80937-31-1
- Chemical Name
- Flosulide
- Synonyms
- ZK-38997;CGP-28328;CGP-28238;Flosulide;N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide;N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide;Methanesulfonamide, N-[6-(2,4-difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden-5-yl]-
- CBNumber
- CB51178758
- Molecular Formula
- C16H13F2NO4S
- Formula Weight
- 353.344
- MOL File
- 80937-31-1.mol
Flosulide Property
- Melting point:
- 156 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 446.9±55.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 6.95±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0011461
- Product name
- FLOSULIDE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- API0011461
- Product name
- FLOSULIDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $1871.1
- Updated
- 2021/12/16
- Product number
- CSN21647
- Product name
- Flosulide
- Packaging
- 25mg
- Price
- $6212
- Updated
- 2021/12/16
- Product number
- CSN21647
- Product name
- Flosulide
- Packaging
- 1mg
- Price
- $1040
- Updated
- 2021/12/16
Flosulide Chemical Properties,Usage,Production
Uses
Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.
in vivo
In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares[1]. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats[3].
IC 50
COX-2
References
[1] Turull A, et al. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. Inflammation. 2001 Apr;25(2):119-28. DOI:10.1023/a:1007122706770
[2] Zimmermann KC, et al. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999 Jan 1;59(1):198-204. PMID:9892207
[3] Heise G, et al. Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis. Nephron. 1998 Oct;80(2):220-6. DOI:10.1159/000045171
Flosulide Preparation Products And Raw materials
Raw materials
Preparation Products
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