6-Methyl-2-pyridinemethanamine

6-Methyl-2-pyridinemethanamine Property

Boiling point:

55-57 °C(Press: 0.1 Torr)

Density 

1.027±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.75±0.39(Predicted)

Appearance

Colorless to light yellow Liquid

Safety

HazardClass 

IRRITANT

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

6-Methyl-2-pyridinemethanamine Chemical Properties,Usage,Production

Uses

(6-Methylpyridin-2-yl)methanamine is a pyridine derivative studied as one of the complexing agent.

Synthesis

General procedure for the synthesis of 6-methyl-2-pyridinemethanamine from 6-methyl-2-pyridinecarbonitrile: 6-methyl-2-pyridinecarbonitrile (10 g, 84.7 mmol) was dissolved in methanol (100 mL), and 10% palladium/carbon catalyst (1 g) was added under stirring conditions. The reaction mixture was stirred at room temperature overnight under the protection of nitrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by filtration and the organic solvent was removed by distillation under reduced pressure to afford 6-methyl-2-pyridinemethanamine (9 g, 87% yield).

References

[1] Patent: CN106279160, 2017, A. Location in patent: Paragraph 0213; 0218; 0219; 0220
[2] Journal of the American Chemical Society, 2015, vol. 137, # 28, p. 8888 - 8891
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 12, p. 3890 - 3894