ChemicalBook > CAS DataBase List > N-(Trifluoroacetyl)glycine

N-(Trifluoroacetyl)glycine

Product Name: N-(Trifluoroacetyl)glycine
CAS No.: 383-70-0
Chemical Name: N-(Trifluoroacetyl)glycine
Synonyms: TFA-Gly;TFA-GLY-OH;TFA-GLYCINE;TRIFLUOROACETYL GLYCINE;n-(trifluoroacetyl)glycine;L- trifluoroacetyl glycine;glycine,N-(trifluoroacetyl)-;N-alpha-Trifluoracetyl-glycin;(2,2,2-trifluoroacetyl)glycine;N-ALPHA-TRIFLUOROACETYL-GLYCINE
CBNumber: CB0383547
Molecular Formula: C4H4F3NO3
Formula Weight: 171.07
MOL File: 383-70-0.mol

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N-(Trifluoroacetyl)glycine Property

Melting point:: 120-121 °C
Boiling point:: 291.6°C
Density: 1.534
Flash point:: 130°C
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, DMSO
form: Solid
pka: 2.99±0.10(Predicted)
color: White
InChI: InChI=1S/C4H4F3NO3/c5-4(6,7)3(11)8-1-2(9)10/h1H2,(H,8,11)(H,9,10)
InChIKey: IFAXXCBMQJNCCF-UHFFFAOYSA-N
SMILES: C(O)(=O)CNC(C(F)(F)F)=O
CAS DataBase Reference: 383-70-0
NIST Chemistry Reference: N-(Trifluoroacetyl)aminoacetic acid(383-70-0)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: T787205
Product name: N-Trifluoroacetylglycine
Packaging: 10g
Price: $415
Updated: 2021/12/16

Usbiological

Product number: T8416-28
Product name: N-Trifluoroacetylglycine
Packaging: 500mg
Price: $355
Updated: 2021/12/16

Matrix Scientific

Product number: 099637
Product name: 2-(2,2,2-Trifluoroacetamido)acetic acid
Purity: 95+%
Packaging: 10g
Price: $395
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002018
Product name: N-TRIFLUOROACETYLGLYCINE
Purity: 95.00%
Packaging: 5G
Price: $1114.58
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 13982
Product name: N-Trifluoroacetylglycine
Packaging: 2.5g
Price: $1880
Updated: 2021/12/16

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N-(Trifluoroacetyl)glycine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

N-Trifluoroacetylglycine (cas# 383-70-0) is a compound useful in organic synthesis.

Definition

ChEBI: N-(trifluoroacetyl)glycine is an N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of trifluoroacetic acid. It is a N-acylglycine, a secondary carboxamide and a trifluoroacetamide.

Synthesis

383-63-1

56-40-6

383-70-0

The general procedure for the synthesis of 2-(2,2,2-trifluoroacetamido)acetic acid from ethyl trifluoroacetate and glycine was carried out as follows: the TFA-α-amino acid was prepared by the method reported in references [1,2] with slight modifications. First, triethylamine (33 mmol, 1.5 eq.) was added to a methanolic solution (22 mL) of glycine (22 mmol). after 5 min, ethyl trifluoroacetate (29 mmol, 1.3 eq.) was added and the reaction mixture was stirred for 24 h. The reaction was carried out by rotary evaporation. Upon completion of the reaction, the solvent was removed by rotary evaporation. The remaining residue was dissolved in water (35 mL) and acidified with concentrated hydrochloric acid (4 mL). After acidification, the mixture was stirred for 15 minutes and then extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, and dried with anhydrous magnesium sulfate. After drying, filter and concentrate by rotary evaporation. If cured products (e.g., L-1a, D-1a, L-2a, D-2a, 3a, L-4a, D-4a to D-8a) are desired, they can be further dried overnight under high vacuum.

References

[1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8298 - 8309
[2] Organic Letters, 2018, vol. 20, # 18, p. 5877 - 5880
[3] Molecules, 2017, vol. 22, # 10,
[4] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
[5] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788

N-(Trifluoroacetyl)glycine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(Trifluoroacetyl)glycine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N-(Trifluoroacetyl)glycine 383-70-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-25

Honest Joy Holdings Limited

Product: N-(Trifluoroacetyl)glycine 383-70-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.9%
Supply Ability: 100 tons
Release date: 2022-02-21

383-70-0, N-(Trifluoroacetyl)glycineRelated Search:

Sodium triacetoxyborohydride N-Acetylglycine 1,1,1-Trifluoro-2,4-pentanedione Glycine 4-Hydroxy-D-(-)-2-phenylglycine N-6-Trifluoroacetyl-L-lysine Ethyl acetamidoacetate ACETYL FLUORIDE DI-N-TFA-L-LYSINE METHYL ESTER N-TFA-L-ALANINE METHYL ESTER N,N'-BIS(TRIFLUOROACETYL) L-CYSTINE DIMETHYL ESTER N-TFA-L-VALINE METHYL ESTER TFA-PHE-OME (S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE N-TFA-L-METHIONINE METHYL ESTER N-TRIFLUOROACETYL-L-TYROSINE METHYL ESTER N-TRIFLUOROACETYL-L-CYSTEINE METHYL ESTER N-TFA-L-PROLINE METHYL ESTER

N-alpha-Trifluoracetyl-glycin

TRIFLUOROACETYL GLYCINE

n-(trifluoroacetyl)glycine

N-ALPHA-TRIFLUOROACETYL-GLYCINE

TFA-GLYCINE

TFA-GLY-OH

[(Trifluoroacetyl)amino]acetic acid

glycine,N-(trifluoroacetyl)-

(2,2,2-Trifluoro-acetylamino)-acetic acid

N-(Trifluoroacetyl)aminoacetic acid

Trifluoroacetyl glycine≥ 99% (HPLC)

2-(2,2,2-trifluoroethanoylamino)ethanoic acid

2-[(2,2,2-trifluoroacetyl)amino]acetic acid

N-(2,2,2-Trifluoroacetyl)glycine

2-(2,2,2-Trifluoroacetamido)acetic acid

(2,2,2-trifluoroacetyl)glycine

Glycine, N-(2,2,2-trifluoroacetyl)-

TFA-Gly

N-(Trifluoroacetyl)glycine USP/EP/BP

TIANFU-CHEM - N-(Trifluoroacetyl)glycine

L- trifluoroacetyl glycine

383-70-0

C4H4NO3F3

C4H4F3NO3

Amino Acids 13C, 2H, 15N

Amino Acids & Derivatives

Amino Acids