N-(Trifluoroacetyl)glycine

N-(Trifluoroacetyl)glycine Property

Melting point:

120-121 °C

Boiling point:

291.6°C

Density 

1.534

Flash point:

130°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, DMSO

form 

Solid

pka

2.99±0.10(Predicted)

color 

White

InChI

InChI=1S/C4H4F3NO3/c5-4(6,7)3(11)8-1-2(9)10/h1H2,(H,8,11)(H,9,10)

InChIKey

IFAXXCBMQJNCCF-UHFFFAOYSA-N

SMILES

C(O)(=O)CNC(C(F)(F)F)=O

CAS DataBase Reference

383-70-0

NIST Chemistry Reference

N-(Trifluoroacetyl)aminoacetic acid(383-70-0)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

N-(Trifluoroacetyl)glycine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

N-Trifluoroacetylglycine (cas# 383-70-0) is a compound useful in organic synthesis.

Definition

ChEBI: N-(trifluoroacetyl)glycine is an N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of trifluoroacetic acid. It is a N-acylglycine, a secondary carboxamide and a trifluoroacetamide.

Synthesis

The general procedure for the synthesis of 2-(2,2,2-trifluoroacetamido)acetic acid from ethyl trifluoroacetate and glycine was carried out as follows: the TFA-α-amino acid was prepared by the method reported in references [1,2] with slight modifications. First, triethylamine (33 mmol, 1.5 eq.) was added to a methanolic solution (22 mL) of glycine (22 mmol). after 5 min, ethyl trifluoroacetate (29 mmol, 1.3 eq.) was added and the reaction mixture was stirred for 24 h. The reaction was carried out by rotary evaporation. Upon completion of the reaction, the solvent was removed by rotary evaporation. The remaining residue was dissolved in water (35 mL) and acidified with concentrated hydrochloric acid (4 mL). After acidification, the mixture was stirred for 15 minutes and then extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, and dried with anhydrous magnesium sulfate. After drying, filter and concentrate by rotary evaporation. If cured products (e.g., L-1a, D-1a, L-2a, D-2a, 3a, L-4a, D-4a to D-8a) are desired, they can be further dried overnight under high vacuum.

References

[1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8298 - 8309
[2] Organic Letters, 2018, vol. 20, # 18, p. 5877 - 5880
[3] Molecules, 2017, vol. 22, # 10,
[4] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
[5] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788