1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one

Product Name: 1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one
CAS No.: 304685-40-3
Chemical Name: 1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one
Synonyms: BRD4-IN-4;WAY-383515;1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one;Benz[cd]indol-2(1H)-one, 1-ethyl-6-(1-pyrrolidinylsulfonyl)-
CBNumber: CB03845246
Molecular Formula: C17H18N2O3S
Formula Weight: 330.4
MOL File: 304685-40-3.mol

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1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one Property

form: Solid
color: Brown to reddish brown

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Hazard and Precautionary Statements (GHS)

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1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one Chemical Properties,Usage,Production

Uses

BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia[1].

References

[1] Feng Y, et al. Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors. Eur J Med Chem. 2018 May 25;152:264-273. DOI:10.1016/j.ejmech.2018.04.048

1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one Suppliers

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304685-40-3, 1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-oneRelated Search:

2H-Indol-2-one, 1,3-dihydro-3-[(5-methyl-2-furanyl)methylene]- N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-CYCLOHEXANECARBOXAMIDE MALEATE 1-(1,3-benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)sulfonyl]piperazine N-(4-chlorophenyl)-2-(thiophen-2-yl)acetamide (4-benzylpiperidin-1-yl)(4-fluorophenyl)methanone Ethanone, 1-(4-bromophenyl)-2-[[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]thio]- Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)- 3-(3,5-dimethyl-1H-pyrazol-1-yl)-N-(4-methylphenyl)propanamide 5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione N-(6-bromobenzo[d]thiazol-2-yl)cyclohexanecarboxamide 1-(4-fluorobenzoyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine Benzamide, N-methyl-4-phenoxy-N-(phenylmethyl)- Benzenesulfonamide, N,N'-1,2-ethanediylbis[3-methyl- Acetamide, N-1H-benzimidazol-2-yl-2-phenoxy- 3-chloro-4-morpholin-4-yl-1-phenylpyrrole-2,5-dione WAY-234759 2-(1,3-benzoxazol-2-ylsulfanyl)-N-phenylacetamide 2-benzylsulfanyl-5-(4-methylphenyl)-1,3,4-oxadiazole

1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one

Benz[cd]indol-2(1H)-one, 1-ethyl-6-(1-pyrrolidinylsulfonyl)-

WAY-383515

BRD4-IN-4

304685-40-3