ChemicalBook > CAS DataBase List > 2,4-Difluorophenylboronic acid

2,4-Difluorophenylboronic acid

Product Name
2,4-Difluorophenylboronic acid
CAS No.
144025-03-6
Chemical Name
2,4-Difluorophenylboronic acid
Synonyms
Difluorophenylboronic acid;B-(2,4-Difluorophenyl)boronic acid;AKOS BRN-0089;CAS:144025-03-6;2,4-difluoroborate;RARECHEM AH PB 0168;2,4-Difluorophenylbo;2,4-Difluorophenylboric acid;2,4-difluorophenylboroic acid;2,4-FLUOROBENZENE BORONIC ACID
CBNumber
CB0385637
Molecular Formula
C6H5BF2O2
Formula Weight
157.91
MOL File
144025-03-6.mol
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2,4-Difluorophenylboronic acid Property

Melting point:
247-250 °C (lit.)
Boiling point:
251.0±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
pka
8.47±0.58(Predicted)
form 
Powder
color 
Off-white to light beige or yellow
BRN 
8616257
InChI
InChI=1S/C6H5BF2O2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,10-11H
InChIKey
QQLRSCZSKQTFGY-UHFFFAOYSA-N
SMILES
B(C1=CC=C(F)C=C1F)(O)O
CAS DataBase Reference
144025-03-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-22
Safety Statements 
37/39-26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
465070
Product name
2,4-Difluorophenylboronic acid
Purity
≥95%
Packaging
5g
Price
$82.5
Updated
2023/06/20
Sigma-Aldrich
Product number
465070
Product name
2,4-Difluorophenylboronic acid
Purity
≥95%
Packaging
25g
Price
$250
Updated
2023/06/20
TCI Chemical
Product number
D3391
Product name
2,4-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
D3391
Product name
2,4-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$136
Updated
2025/07/31
TRC
Product number
D447295
Product name
2,4-Difluorophenylboronic acid
Packaging
50g
Price
$275
Updated
2021/12/16
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2,4-Difluorophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

off-white to light beige or yellow powder

Uses

suzuki reaction

Uses

2,4-Difluorophenylboronic Acid is used as a reagent in suzuki-miyaura coupling reactions such as in the synthesis of enantiomerically pure 3,3''-bis-arylated BINOL derivatives. Also used in the synthesis of highly efficient phospherescent iridium (III) complexes which are used for light-emiiting diodes.

Synthesis

121-43-7

144025-04-7

144025-03-6

(B) A solution of trimethyl borate (25.98 g, 0.25 mol, Fluka) and 2,4-difluorophenylmagnesium bromide (0.25 mol) in tetrahydrofuran (200 mL) was added dropwise simultaneously to a reactor containing tetrahydrofuran (125 mL) over a period of 1 h under nitrogen protection, maintaining the reaction temperature at -15 °C. The reaction was carried out by stirring the reaction mixture for 15 min. After the dropwise addition, the reaction mixture was continued to be stirred at -15°C for 15 minutes. Subsequently, the temperature of the reaction system was raised to 0 °C and water (17.5 mL) and 10% sulfuric acid solution (125 mL) were slowly added over 10 and 15 min, respectively. After the reaction was complete, water (250 mL) was added to ensure complete dissolution of the product, which was subsequently extracted with ether (3 x 150 mL). The organic phases were combined and concentrated to dryness under reduced pressure to afford the crude 2,4-difluorophenylboronic acid (36.98 g, 90% purity, 84.3% yield), which was used directly in the subsequent cross-coupling reaction without further purification.

References

[1] Patent: US5312975, 1994, A
[2] Patent: EP494419, 1992, A2
[3] Patent: US5312975, 1994, A
[4] Patent: EP494419, 1992, A2
[5] Patent: US2012/309971, 2012, A1. Location in patent: Page/Page column 2-3

2,4-Difluorophenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Difluorophenylboronic acid Suppliers

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View Lastest Price from 2,4-Difluorophenylboronic acid manufacturers

LY Global chemicals co.,ltd .
Product
2,4-Difluorophenylboronic acid 144025-03-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%Min
Supply Ability
1000kg
Release date
2023-03-13
Shijiazhuang tongyang Import and Export Co., LTD
Product
Difluorophenylboronic acid 144025-03-6
Price
US $40.00/KG
Min. Order
1KG
Purity
99
Supply Ability
10 tons
Release date
2021-08-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-Difluorophenylboronic acid 144025-03-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

144025-03-6, 2,4-Difluorophenylboronic acidRelated Search:

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