L-DIHYDROOROTIC ACID

Product Name: L-DIHYDROOROTIC ACID
CAS No.: 5988-19-2
Chemical Name: L-DIHYDROOROTIC ACID
Synonyms: DNTPS;Dihydroorotic acid;DIHYDRO-L-OROTIC ACID;L-HYDROOROTIC ACID;(S)-Dihydroorotate;(S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid;DI-H-OROTATE;(S)-di-H-orotate;L-4,5-dihydroorotic;L-DIHYDROOROTIC ACID
CBNumber: CB0386533
Molecular Formula: C5H6N2O4
Formula Weight: 158.11
MOL File: 5988-19-2.mol

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L-DIHYDROOROTIC ACID Property

Melting point:: 254-255 °C (dec.)(lit.)
Boiling point:: 283.16°C (rough estimate)
Density: 1.523
refractive index: 1.5090 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Water (Slightly, Heated, Sonicated)
pka: 2.82±0.20(Predicted)
form: Powder
color: White to off-white
Water Solubility: Soluble in water (partly), and dimethyl formamide.
InChI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
InChIKey: UFIVEPVSAGBUSI-REOHCLBHSA-N
SMILES: C1(=O)NC(=O)C[C@@H](C(O)=O)N1
CAS DataBase Reference: 5988-19-2(CAS DataBase Reference)
NIST Chemistry Reference: Orotic acid, dihydro-, l-(5988-19-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D7128
Product name: L-Dihydroorotic acid
Purity: ≥99%
Packaging: 1g
Price: $314
Updated: 2025/07/31

Sigma-Aldrich

Product number: D7128
Product name: L-Dihydroorotic acid
Purity: ≥99%
Packaging: 5g
Price: $1030
Updated: 2025/07/31

Sigma-Aldrich

Product number: D7128
Product name: L-Dihydroorotic acid
Purity: ≥99%
Packaging: 500mg
Price: $177
Updated: 2025/07/31

TRC

Product number: D451530
Product name: L-Dihydroorotic acid
Packaging: 500mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-W016211
Product name: L-Dihydroorotic acid
Purity: ≥98.0%
Packaging: 5g
Price: $30
Updated: 2021/12/16

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L-DIHYDROOROTIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

L-Dihydroorotic acid a metabolite.

Definition

ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.

Biochem/physiol Actions

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

IC 50

Microbial Metabolite; Human Endogenous Metabolite

L-DIHYDROOROTIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Ribavirin Disodium 5'-Inosinate CALCIUM5'-RIBONUCLEOTIDES Idoxuridine

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L-DIHYDROOROTIC ACID Suppliers

China 313 Germany 3 India 5 Slovakia 1 Switzerland 3 United Kingdom 9 United States 31 Global 365

Guangzhou Langou Biotech Co., Ltd.

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Tiantai Yisheng Biochemical Technology Co., Ltd

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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Alfa Aesar

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Energy Chemical

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View Lastest Price from L-DIHYDROOROTIC ACID manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: L-DIHYDROOROTIC ACID 5988-19-2
Price: US $99.00-66.00/kg
Min. Order: 0.001kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: L-DIHYDROOROTIC ACID 5988-19-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: L-Dihydroorotic acid 5988-19-2
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-07

5988-19-2, L-DIHYDROOROTIC ACIDRelated Search:

Uridine-5'-diphosphate disodium salt Orotic acid Sodium phosphate tribasic dodecahydrate Trisodium phosphate Cytidine 5′-(tetrahydrogen triphosphate), xsodium salt, hydrate Sulbactum Sodium D-HYDROOROTIC ACID DL-Hydroorotic acid 1-METHYL-L-4,5-DIHYDROOROTIC ACID L-DIHYDROOROTIC ACID ATP disodium salt CTP xsodium Inosine Cytidine-5'-diphosphate disodium salt 2'-Deoxyuridine URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT UDP SODIUM SALT (S)-BENZYL 1-METHYL-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE

L-DIHYDROOROTIC ACID

L-HYDROOROTIC ACID

DIHYDRO-L-OROTIC ACID

(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid

2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid

L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid

(S)-(+)-HYDROOROTIC ACID

(4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid

L-4,5-dihydroorotic acid

(S)-4,5-dihydroorotate

(S)-4,5-dihydroorotic acid

(S)-4-pyrimidinecarboxylic acid

(S)-di-H-orotate

4,5-dihydro-L-orotate

DI-H-OROTATE

L-4,5-dihydroorotate

4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-, (4S)-

L-4,5-dihydroorotic

Deoxyribonucleoside- 5′-triphosphate

(S)-Dihydroorotate

(S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid

Adenosine-5-triphosphoric acid Na2

Adenosine-5'-diphosphoric acid Na2

Deoxyribonucein acid(fish sperm)

DNTPS

Guanosine-5-diphosphate disodiun

Guanosine-5-monophosphate disodiun

Guanosine-5'-triphosphate disodiun

t-Ribonuclein acid,yeast

4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-

2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid, L-Hydroorotic acid, Dihydro-L-orotic acid

(4S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid

(6S)-Hexahydro-2,4-dioxopyrimidine-6β-carboxylic acid

(S)-Dihydroorotic acid

Dihydroorotic acid

Hexahydro-2,6-dioxopyrimidine-4α-carboxylic acid

Inosine-5-triphosphate trisodium

Ribonuclein acid,yeast

(4S)-2,6-dioxo-1,3-diazinane-4-carboxylate

L-5,6-Dihydroorotic acid

L-DIHYDROOROTIC ACID USP/EP/BP

(S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid,L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid,L-Dihydroorotic acid,L-Dihydroorotic Acid

(S)-dihydrooroticaci

L-4, 5-dihydrowhey acid

L-DihydrooroticacidL-Dihydrooroticacid

Cytidine-5-phosphate disodium salt (CMP)

Guanosine Phosphate Disodium Salt (GMP)

L-Dihydroorotic acid, 10 mM in DMSO

<sc>L</sc>-Dihydroorotic acid

He replaced the intermediate of Ruilin/L-4,5-dihydroorotic acid

5988-19-2

6757-67-8

BioChemical

Nucleotide

Metabolomics

Metabolites and Cofactors on the Metabolic Pathways Chart

Metabolic Pathways

Heterocycles