ChemicalBook > CAS DataBase List > L-DIHYDROOROTIC ACID

L-DIHYDROOROTIC ACID

Product Name
L-DIHYDROOROTIC ACID
CAS No.
5988-19-2
Chemical Name
L-DIHYDROOROTIC ACID
Synonyms
DNTPS;Dihydroorotic acid;DIHYDRO-L-OROTIC ACID;L-HYDROOROTIC ACID;(S)-Dihydroorotate;(S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid;DI-H-OROTATE;(S)-di-H-orotate;L-4,5-dihydroorotic;L-DIHYDROOROTIC ACID
CBNumber
CB0386533
Molecular Formula
C5H6N2O4
Formula Weight
158.11
MOL File
5988-19-2.mol
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L-DIHYDROOROTIC ACID Property

Melting point:
254-255 °C (dec.)(lit.)
Boiling point:
283.16°C (rough estimate)
Density 
1.523
refractive index 
1.5090 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Water (Slightly, Heated, Sonicated)
pka
2.82±0.20(Predicted)
form 
Powder
color 
White to off-white
Water Solubility 
Soluble in water (partly), and dimethyl formamide.
InChIKey
UFIVEPVSAGBUSI-REOHCLBHSA-N
CAS DataBase Reference
5988-19-2(CAS DataBase Reference)
NIST Chemistry Reference
Orotic acid, dihydro-, l-(5988-19-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7128
Product name
L-Dihydroorotic acid
Purity
≥99%
Packaging
1g
Price
$296
Updated
2024/03/01
Sigma-Aldrich
Product number
D7128
Product name
L-Dihydroorotic acid
Purity
≥99%
Packaging
5g
Price
$399.6
Updated
2024/03/01
Alfa Aesar
Product number
H60429
Product name
L-Dihydroorotic acid, 98%
Packaging
1g
Price
$156
Updated
2024/03/01
Alfa Aesar
Product number
H60429
Product name
L-Dihydroorotic acid, 98%
Packaging
5g
Price
$613
Updated
2024/03/01
Sigma-Aldrich
Product number
D7128
Product name
L-Dihydroorotic acid
Purity
≥99%
Packaging
500mg
Price
$167
Updated
2024/03/01
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L-DIHYDROOROTIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

L-Dihydroorotic acid a metabolite.

Definition

ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.

Biochem/physiol Actions

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

L-DIHYDROOROTIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Ribavirin Disodium 5'-Inosinate CALCIUM5'-RIBONUCLEOTIDES Idoxuridine
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L-DIHYDROOROTIC ACID Suppliers

China 248 Germany 3 India 5 Slovakia 1 Switzerland 3 United Kingdom 9 United States 31 Global 300
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View Lastest Price from L-DIHYDROOROTIC ACID manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Dihydroorotic acid 5988-19-2
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-07
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
L-DIHYDROOROTIC ACID 5988-19-2
Price
US $99.00-66.00/kg
Min. Order
0.001kg
Purity
99%
Supply Ability
5000
Release date
2024-08-09
Hebei Weibang Biotechnology Co., Ltd
Product
L-DIHYDROOROTIC ACID 5988-19-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30

5988-19-2, L-DIHYDROOROTIC ACIDRelated Search:

Uridine-5'-diphosphate disodium salt Orotic acid Sodium phosphate tribasic dodecahydrate Trisodium phosphate Cytidine 5′-(tetrahydrogen triphosphate), xsodium salt, hydrate Sulbactum Sodium D-HYDROOROTIC ACID DL-Hydroorotic acid 1-METHYL-L-4,5-DIHYDROOROTIC ACID L-DIHYDROOROTIC ACID ATP disodium salt CTP xsodium Inosine Cytidine-5'-diphosphate disodium salt 2'-Deoxyuridine URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT UDP SODIUM SALT (S)-BENZYL 1-METHYL-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE

  • L-DIHYDROOROTIC ACID
  • L-HYDROOROTIC ACID
  • DIHYDRO-L-OROTIC ACID
  • (S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
  • 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
  • L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
  • (S)-(+)-HYDROOROTIC ACID
  • (4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid
  • L-4,5-dihydroorotic acid
  • (S)-4,5-dihydroorotate
  • (S)-4,5-dihydroorotic acid
  • (S)-4-pyrimidinecarboxylic acid
  • (S)-di-H-orotate
  • 4,5-dihydro-L-orotate
  • DI-H-OROTATE
  • L-4,5-dihydroorotate
  • 4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-, (4S)-
  • L-4,5-dihydroorotic
  • Deoxyribonucleoside- 5′-triphosphate
  • (S)-Dihydroorotate
  • (S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid
  • Adenosine-5-triphosphoric acid Na2
  • Adenosine-5'-diphosphoric acid Na2
  • Deoxyribonucein acid(fish sperm)
  • DNTPS
  • Guanosine-5-diphosphate disodiun
  • Guanosine-5-monophosphate disodiun
  • Guanosine-5'-triphosphate disodiun
  • t-Ribonuclein acid,yeast
  • 4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-
  • 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid, L-Hydroorotic acid, Dihydro-L-orotic acid
  • (4S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid
  • (6S)-Hexahydro-2,4-dioxopyrimidine-6β-carboxylic acid
  • (S)-Dihydroorotic acid
  • Dihydroorotic acid
  • Hexahydro-2,6-dioxopyrimidine-4α-carboxylic acid
  • Inosine-5-triphosphate trisodium
  • Ribonuclein acid,yeast
  • (4S)-2,6-dioxo-1,3-diazinane-4-carboxylate
  • L-5,6-Dihydroorotic acid
  • L-DIHYDROOROTIC ACID USP/EP/BP
  • (S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid,L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid,L-Dihydroorotic acid,L-Dihydroorotic Acid
  • (S)-dihydrooroticaci
  • L-4, 5-dihydrowhey acid
  • L-DihydrooroticacidL-Dihydrooroticacid
  • Cytidine-5-phosphate disodium salt (CMP)
  • Guanosine Phosphate Disodium Salt (GMP)
  • 5988-19-2
  • BioChemical
  • Nucleotide
  • Metabolomics
  • Metabolites and Cofactors on the Metabolic Pathways Chart
  • Metabolic Pathways
  • Heterocycles
  • Miscellaneous Biochemicals
  • Amino Acid Derivatives
  • 5988-19-2