ChemicalBook > CAS DataBase List > TERT-BUTYL N-(BENZYLOXY)CARBAMATE

TERT-BUTYL N-(BENZYLOXY)CARBAMATE

Product Name: TERT-BUTYL N-(BENZYLOXY)CARBAMATE
CAS No.: 79722-21-7
Chemical Name: TERT-BUTYL N-(BENZYLOXY)CARBAMATE
Synonyms: TERT-BUTYL BENZYLOXYCARBAMATE;Xanthoanthrafil-d3;LABOTEST-BB LT00452293;N-Boc-O-benzylhydroxylamine;TERT-BUTYL N-(BENZYLOXY)CARBAMATE;tert-Butyl (benzyloxy)carbamate 99%;tert-Butyl N-(Benzyloxy)carbamate >tert-Butyl N-(benzyloxy)carbamate ,98%;tert-Butyl N-(benzyloxy)carbamate, 98.5%;tert-ButylN-(benzyloxy)carbamate≥ 99%(N)
CBNumber: CB0393272
Molecular Formula: C12H17NO3
Formula Weight: 223.27
MOL File: 79722-21-7.mol

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TERT-BUTYL N-(BENZYLOXY)CARBAMATE Property

Melting point:: 45-47 °C (lit.)
Density: 1.078±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White
InChI: InChI=1S/C12H17NO3/c1-12(2,3)16-11(14)13-15-9-10-7-5-4-6-8-10/h4-8H,9H2,1-3H3,(H,13,14)
InChIKey: MZNBNPWFHGWAGH-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NOCC1=CC=CC=C1
CAS DataBase Reference: 79722-21-7

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 407690
Product name: tert-Butyl N-(benzyloxy)carbamate
Purity: 99%
Packaging: 5g
Price: $63
Updated: 2023/01/07

Sigma-Aldrich

Product number: 407690
Product name: tert-Butyl N-(benzyloxy)carbamate
Purity: 99%
Packaging: 25g
Price: $168
Updated: 2023/01/07

TCI Chemical

Product number: B1799
Product name: tert-Butyl N-(Benzyloxy)carbamate
Purity: >98.0%(N)
Packaging: 5g
Price: $83
Updated: 2025/07/31

TCI Chemical

Product number: B1799
Product name: tert-Butyl N-(Benzyloxy)carbamate
Purity: >98.0%(N)
Packaging: 25g
Price: $243
Updated: 2025/07/31

TRC

Product number: B692890
Product name: tert-Butyl N-(Benzyloxy)carbamate
Packaging: 5g
Price: $90
Updated: 2021/12/16

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TERT-BUTYL N-(BENZYLOXY)CARBAMATE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

tert-Butyl N-(benzyloxy)carbamate was used in the preparation of seven-membered cyclic hydroxamic acids. It may be used in the synthesis of 2-(N-formyl-N-hydroxyamino) ethylphosphonate (IPP).

Uses

tert-Butyl N-(Benzyloxy)carbamate has been used in the synthesis of Deferoxamine Mesylate (D228980), an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients

General Description

tert-Butyl N-(benzyloxy)carbamate (tert-butyl benzyloxycarbamate), a protected hydroxylamine, is an N-alkyl-N-benzyloxy carbamate. Its C-N cross coupling reaction with fluorescein ditriflate has been reported. It participates in facile intramolecular cyclization with various carbon nucleophiles to afford functionalized 5- and 6-membered protected cyclic hydroxamic acids.

Synthesis

24424-99-5

2687-43-6

79722-21-7

General procedure: synthesis of Intermediate 153: tert-butyl N-(benzyloxy)carbamate. To a solution of O-benzylhydroxylamine hydrochloride (225 g, 1.44 mol) in dichloromethane (300 mL) was added an aqueous sodium bicarbonate solution (261 g, 3.11 mol, 300 ml). After 1 hour of reaction, di-tert-butyl dicarbonate (375 g, 1.72 mol) was slowly added at 0°C. The reaction mixture was stirred in a water/ice bath at 0 °C for 60 min, followed by continued stirring for 16 h at room temperature. Upon completion of the reaction, the reaction was quenched by addition of 300 mL of aqueous sodium bicarbonate. The aqueous phase was separated and extracted with dichloromethane (3 x 500 mL), the organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by silica gel fast column chromatography (eluent: petroleum ether/ethyl acetate=10:1) afforded 220 g (69% yield) of the target compound, tert-butyl N-(benzyloxy)carbamate, as a yellow oil.1H NMR (300 MHz, CDCl3) δ: 1.43 (9H,s), 4.85 (2H,s), 7.19-7.21 (1H brs), 7.30-7.40 (5H, m).

References

[1] Journal of Organic Chemistry, 1997, vol. 62, # 26, p. 9148 - 9159
[2] Archiv der Pharmazie, 2016, vol. 349, # 5, p. 373 - 382
[3] Journal of Organic Chemistry, 1983, vol. 48, p. 24
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 24, p. 8549 - 8555
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 19, p. 8847 - 8858

TERT-BUTYL N-(BENZYLOXY)CARBAMATE Preparation Products And Raw materials

Raw materials

Benzyl chloride Acetonitrile N-Hydroxyphthalimide N,N-Dimethylformamide Potassium hydroxide Di-tert-butyl dicarbonate Potassium carbonate N,N-Diisopropylethylamine Hydrazine hydrate Sodium bicarbonate Dichloromethane Dimethyl sulfoxide Isopropyl alcohol Sodium carbonate

Preparation Products

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TERT-BUTYL N-(BENZYLOXY)CARBAMATE Suppliers

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View Lastest Price from TERT-BUTYL N-(BENZYLOXY)CARBAMATE manufacturers

Career Henan Chemical Co

Product: tert-butyl benzyloxycarbamate 79722-21-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-25

79722-21-7, TERT-BUTYL N-(BENZYLOXY)CARBAMATERelated Search:

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE O-(4-NITROBENZYL)HYDROXYLAMINE HYDROCHLORIDE N-BOC-3-(4-CYANOPHENYL)OXAZIRIDINE TERT-BUTYL N-(BENZYLOXY)CARBAMATE ETHYL N-METHOXYCARBAMATE N-Hydroxyurethane RARECHEM AL BO 1195 tert-Butyl N-hydroxycarbamate

LABOTEST-BB LT00452293

TERT-BUTYL N-(BENZYLOXY)CARBAMATE

N-(BENZYLOXY)CARBAMIC ACID TERT-BUTYL ESTER

N-Boc-O-benzylhydroxylamine

TERT-BUTYL BENZYLOXYCARBAMATE

O-Benzylhydroxylamine, N-BOC protected, tert-Butyl (phenylmethoxy)carbamate

tert-Butyl (benzyloxy)carbamate 99%

tert-Butyl N-(benzyloxy)carbamate ,98%

N-Boc-Bn Tert-butyl n-(benzyloxy)carbamate

tert-ButylN-(benzyloxy)carbamate≥ 99%(N)

tert-Butyl N-(benzyloxy)carbamate, 98.5%

tert-Butyl N-(Benzyloxy)carbamate &gt

Carbamic acid, N-(phenylmethoxy)-, 1,1-dimethylethyl ester

TERT-BUTYL N-(BENZYLOXY)CARBAMATE ISO 9001：2015 REACH

Carbamic acid, N-(phenylmethoxy)-, 1,1-dimethylethyl ester, 95+%

Xanthoanthrafil-d3

<i>tert</i>-Butyl <i>N</i>-(benzyloxy)carbamate

79722-21-7

C6H5CH2ONHCO2CCH33

Building Blocks

Organic Building Blocks

Nitrogen Compounds

Protected Amines

Hydroxylamines

Hydroxylamines (O-Substituted)

Hydroxylamines (N-Substituted)

Hydroxylamines

Hydroxylamines (N-Substituted)

Hydroxylamines (O-Substituted)

Nitrogen Compounds

Organic Building Blocks

Protected Amines