ERYTHROSIN B Property

Melting point:

142~144℃

Density 

0.98

vapor pressure 

0Pa at 25℃

Flash point:

285℃

storage temp. 

room temp

solubility 

100g/l

Colour Index 

45430

pka

4.1(at 25℃)

form 

Fine Powder

color 

Deep red to brown

PH

6-7 (10g/l, H2O, 20℃)

PH Range

0(yellow)-3.6(red)

Water Solubility 

Soluble in water

λmax

525nm

Merck 

14,3693

BRN 

1443945

Stability:

Stable. Incompatible with strong oxidizing agents.

Biological Applications

Detecting gene expression,phosphoproteins,protease,stress biomarkers; treating age-related macular degeneration,arteriosclerosis,bone metabolic diseases,burns,cancer,diabetes,human immunodeficiency virus infection,obesity

Major Application

color filter, light emitting diodes, nanosensors, imaging materials, inks, paints, colored bubbles, detergents, cleaners, cosmetics, oral care agent, hair dyes, antiseptic, treatment of burns, diabetes, obesity, cancer, viral diseases, radio chemotheray, photodynamic therapy

InChIKey

RAGZEDHHTPQLAI-UHFFFAOYSA-L

LogP

-1.163 at 25℃

CAS DataBase Reference

16423-68-0

EPA Substance Registry System

Erythrosine B (16423-68-0)

Safety

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

LM5950000

HS Code 

32129000

Hazardous Substances Data

16423-68-0(Hazardous Substances Data)

Toxicity

LD50 in male, female mice, male, female rats (g/kg): 0.40, 0.32, 0.34, 0.37 i.p.; 6.7, 6.9, 7.4, 6.8 orally (Butterworth); LD50 in mice, rats (mg/kg): 2558, 2891 orally (Yankell)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

ERYTHROSIN B Chemical Properties,Usage,Production

Description

FD & C Red No. 3 is principally the disodium salt of the monohydrate of 9(ocarboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-3H- xanthen-3-one.
The colorant is a brown powder that dissolves in water to give a solution red at neutrality, with a yellow-brown precipitate in acid, and with a red precipitate in base. When dissolved in concentrated sulfuric acid, it yields a brown-yellow solution that evolves iodine and a precipitate of the free acid when heated.
FD & C Red No. 3 is used in dietary supplements, confectionery products, dairy products, cherries, jellies, jams, dessert powders, canned fruit and vegetable products, fish products, condiment sauces and bakery goods.1 .

Chemical Properties

red to brown powder

Uses

antibacterial

Uses

Erythrosin B (FD&C Red #3) is a colorant. It is not recommended for use below ph 5.0, being insoluble at ph 3–5 but being stable at ph 7 and 8. It has a solubility in water of 9 g/100 ml at 25°c. It has fair stability to oxidation and poor to fair stability to light, while having good stability in 10% sugar systems. It has exceptional clarity and brilliance, having a bluish pink hue with very good tinctorial strength. It has poor compatibility with food components and is used in candies and confections as well as cherry dyeing. The common name is erythrosine.

Uses

Erythrosine B is a derivative of fluorone and is used as a cherry-pink synthetic colour additives used on food products.

Uses

Biological stain; color additive.

Definition

ChEBI: An organic sodium salt that is the disodium salt of 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-8a,10a-dihydroxanthen-9-yl)benzoic acid.

Preparation

fluorescent element (C.I. Acid Yellow 73, C.I. 45350) or ethanol in aqueous solution of the four iodine, then into sodium salt.

General Description

Erythrosin B (C.I. 45430)for microscopy Certistain^?, is a dry dye for microscopy that is often used as a counterstain, vizualising proteins, connective tissues, fibers and keratin in sample material of human origin. Depending on user requirements and personal preferences, it can be used for the preparation of the commonly used aqueous or alcoholic Erythrosin B staining solutions. As the dye belongs to the portfolio of Certistain^? dyes, it is chemically analyzed according to strict specifications before release (CE marked and IVD product) and a high staining quality, with reliable staining results is guaranteed. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Erythrosin B, also called as eosin B, is a xanthene dye. It belongs to the family of fluorescein dyes. Erythrosin B is an artificial food dye that induces hyperkinesis when swallowed by susceptible children. It plays a major role in inhibiting dopamine uptake and high affinity 3H-ouabain binding and ion transport in synaptosomes from rat caudate nucleus.

storage

Room temperature

Properties and Applications

blue light pink. Soluble in water is cherry red, no fluorescence. The strong sulfuric acid is palm in light yellow, diluted into palm yellow light precipitation. In water solution to join sodium hydroxide to create soluble red precipitate.