2-Fluoro-5-bromobenzotrifluoride
- Product Name
- 2-Fluoro-5-bromobenzotrifluoride
- CAS No.
- 393-37-3
- Chemical Name
- 2-Fluoro-5-bromobenzotrifluoride
- Synonyms
- 4-BROMO-1-FLUORO-2-(TRIFLUOROMETHYL)BENZENE;5-BROMO-2-FLUOROBENZOTRIFLUORIDE;4-FLUOR;5-BROMO-2-FLUORO-;5-Bromo-2-Fluorobenzotrifluori;5-Bromo-2-florobenzotrifluoride;2-FLUORO-5-BROMO BENZOTRIFLUORIDE;5-Bromo-2-fluorobenzotrifluoride97%;5-Bromo-2-fluorobenzotrifluoride 97%;5-Bromo-2-fluorobenzotrifluoride >
- CBNumber
- CB0393984
- Molecular Formula
- C7H3BrF4
- Formula Weight
- 243
- MOL File
- 393-37-3.mol
2-Fluoro-5-bromobenzotrifluoride Property
- Melting point:
- 203 °C(Solv: hexane (110-54-3))
- Boiling point:
- 79-80 °C/50 mmHg (lit.)
- Density
- 1.72 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.462(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- Specific Gravity
- 1.720
- color
- Clear colorless to pale yellow
- Water Solubility
- Soluble in water 700 g/L (20°C)
- BRN
- 2643550
- InChI
- InChI=1S/C7H3BrF4/c8-4-1-2-6(9)5(3-4)7(10,11)12/h1-3H
- InChIKey
- AJLIJYGWAXPEOK-UHFFFAOYSA-N
- SMILES
- C1(F)=CC=C(Br)C=C1C(F)(F)F
- CAS DataBase Reference
- 393-37-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 23-24/25-36-26-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 549096
- Product name
- 5-Bromo-2-fluorobenzotrifluoride
- Purity
- 97%
- Packaging
- 5g
- Price
- $26
- Updated
- 2023/06/20
- Product number
- B2872
- Product name
- 5-Bromo-2-fluorobenzotrifluoride
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- B2872
- Product name
- 5-Bromo-2-fluorobenzotrifluoride
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $74
- Updated
- 2025/07/31
- Product number
- B685788
- Product name
- 4-Bromo-1-fluoro-2-(trifluoromethyl)benzene
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 1800-B-52
- Product name
- 5-Bromo-2-fluorobenzotrifluoride
- Purity
- 97%
- Packaging
- 5G
- Price
- $10
- Updated
- 2021/12/16
2-Fluoro-5-bromobenzotrifluoride Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
Pharmaceutical Intermediates.
Uses
5-Bromo-2-fluorobenzotrifluoride may be used in the preparation of:
- 3,5-bis(4-fluoro-3-trifluoromethylphenyl)phenol
- 9,9-bis(2-ethylhexyl)-2,7-bis[4-fluoro-3-trifluoromethylphenyl]-9H-fluorene
- 3-trifluoromethyl-4-fluoro phenyl boronic acid
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 2022, 1947 DOI: 10.1021/ja01200a060
General Description
5-Bromo-2-fluorobenzotrifluoride is commonly used in the preparation poly(arylene ether)s (PAEs).
Synthesis
392-85-8
393-37-3
The general procedure for synthesizing 2-fluoro-5-bromobenzotrifluoride from 2-fluorobenzotrifluoride was as follows: referring to Example 4, 400 g of concentrated sulfuric acid, 400 g of 2-fluorobenzotrifluoride, 20 g of lithium bromide, 20 g of ferric bromide, 20 g of tetrabutylammonium bromide, and 273.17 g of bromine were added to a 2000 mL three-necked flask, in sequence. The reaction temperature was controlled to be between 35-45°C. Samples were taken after 6 hours of reaction and showed 0.36% of raw material remaining by gas chromatography (GC). The reaction mixture was cooled to below 30 °C, transferred to a 2000 mL dispensing funnel and allowed to stand for 1 h to separate the acid layer. The crude product was transferred to a 2000 mL flask and 1000 g of water was added under stirring and the pH was adjusted to 7 by adding 10% sodium hydroxide solution dropwise to give 550.3 g of 2-fluoro-5-bromobenzotrifluoride crude oil in 92.84% yield. The crude oil was distilled under reduced pressure to obtain 517.18 g of pure product with a yield of 93.98% and a product purity of 95.9%.
References
[1] Patent: CN105152853, 2017, B. Location in patent: Paragraph 0029
2-Fluoro-5-bromobenzotrifluoride Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-5-bromobenzotrifluoride Suppliers
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- --
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- info@pschemicals.com
- Country
- The Netherlands
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View Lastest Price from 2-Fluoro-5-bromobenzotrifluoride manufacturers
- Product
- 2-Fluoro-5-bromobenzotrifluoride 393-37-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-01
- Product
- 2-Fluoro-5-bromobenzotrifluoride 393-37-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 2-Fluoro-5-bromobenzotrifluoride 393-37-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08