Eperisone
Description Pharmacological action Side effects- Product Name
- Eperisone
- CAS No.
- 64840-90-0
- Chemical Name
- Eperisone
- Synonyms
- EPERISONE;Eperisone Monomer;Eperisone USP/EP/BP;4'-ethyl-2-methyl-3-piperidinopropiophenone;1-(4-ethylphenyl)-2-methyl-3-piperidino-propan-1-one;1-(4-ethylphenyl)-2-methyl-3-(1-piperidyl)propan-1-one;1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanon;1-(4-ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one;1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanone;1-(4-ethylphenyl)-2-methyl-3-piperidin-1-yl-propan-1-one
- CBNumber
- CB0396718
- Molecular Formula
- C17H25NO
- Formula Weight
- 259.39
- MOL File
- 64840-90-0.mol
Eperisone Property
- Boiling point:
- 386.8±35.0 °C(Predicted)
- Density
- 0.994±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.46±0.10(Predicted)
- CAS DataBase Reference
- 64840-90-0(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- API0002560
- Product name
- EPERISONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $525
- Updated
- 2021/12/16
- Product number
- API0002560
- Product name
- EPERISONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1697.85
- Updated
- 2021/12/16
- Product number
- 64840900
- Product name
- 1-(4-Ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one
- Packaging
- 1g
- Price
- $659.4
- Updated
- 2021/12/16
- Product number
- CM181076
- Product name
- 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $729
- Updated
- 2021/12/16
- Product number
- MT-50799
- Product name
- Eperisone
- Purity
- 98%
- Packaging
- 5g
- Price
- $730
- Updated
- 2021/12/16
Eperisone Chemical Properties,Usage,Production
Description
Apiresone is a central skeletal muscle relaxant with various pharmacological effects. Animal experiments suggest that eperisone hydrochloride can dose-dependently inhibit decerebral tonic (γ-rigid) and ischemic decerebral tonic (α-rigid) induced by interthalamic transection in rats, and inhibit the stimulation of the dorsal spinal cord in cats with spinal cord injury. The evoked monosynaptic and polysynaptic reflex potentials may reduce the sensitivity of muscle spindles by inhibiting the γ-neuron system.
Pharmacological action
Eperisone is an antispasmodic agent used in the study of disorders characterized by muscle stiffness and pain. It works by relaxing skeletal and vascular smooth muscles, such as reducing muscle tone, improving circulation and suppressing pain reflexes. Eperisone is a centrally acting muscle relaxant that inhibits pain reflex pathways and has vasodilatory effects.
Side effects
Serious adverse reactions include: shock, abnormal liver function, abnormal renal function, abnormal blood picture; the following adverse reactions may occur: skin, rash, itching, etc.; mental nerves, insomnia, headache, drowsiness, body stiffness, numbness of limbs, decreased consciousness, limbs Weakness, unsteady standing, etc.; Digestive system, nausea, vomiting, loss of appetite, stomach discomfort, abnormal liver function, etc.; Urinary system, urinary retention, urinary incontinence, feeling of incomplete urination, etc., occasionally abnormal renal function; systemic symptoms, Fatigue, occasional dizziness, decreased muscle tension, etc.; other, facial flushing, sweating, etc.
Originator
Myonal,Eisai,Japan,1983
Definition
ChEBI: 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one is an aromatic ketone that is N-propylpiperidine in which a hydrogen at positon 2 of the propyl group is replaced by a p-ethylbenzoyl group. It is a member of piperidines and an aromatic ketone.
Manufacturing Process
To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone, 28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and the resulting mixture is heated to reflux on an oil bath with stirring. The heating is continued, and when the reaction mixture solidifies, the state being a sign of completion of the reaction, there are added 500 ml of acetone thereinto. The solidified mass is pulverized by crush, recovered by filtration and washed with acetone. 144 g of the crude dry crystalline substance is thus obtained, which is the hydrochloride of the purposed product. The hydrochloride is recrystallized from isopropanol, and there are obtained the crystalline needles having the melting point of 170°C to 172°C.
Therapeutic Function
Muscle relaxant
Eperisone Preparation Products And Raw materials
Raw materials
Preparation Products
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- China
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View Lastest Price from Eperisone manufacturers
- Product
- Eperisone 64840-90-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Eperisone 64840-90-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-07