2,2,6-Trimethyl-4H-1,3-dioxin-4-one

ChemicalBook > CAS DataBase List > 2,2,6-Trimethyl-4H-1,3-dioxin-4-one

2,2,6-Trimethyl-4H-1,3-dioxin-4-one

Description Reference

Product Name: 2,2,6-Trimethyl-4H-1,3-dioxin-4-one
CAS No.: 5394-63-8
Chemical Name: 2,2,6-Trimethyl-4H-1,3-dioxin-4-one
Synonyms: 2,2,6-TRIMETHYL-1,3-DIOXIN-4-ONE;Diketton Acetone Adduct;2,2,6-TRIMETHYL-1,3-DIOXEN-4-ONE;TKD;2,2,6-TrimethyL;-4H-1,3-dioxin-4-one;DIKETE ACETONE ADDUCT;DIKETENE ACETONE ADDUCT;2,2,6-Trimethyl-4H-1,3-dioxin-;Trimethyl-(4H)-1,3-dioxin-4-one
CBNumber: CB0412977
Molecular Formula: C7H10O3
Formula Weight: 142.15
MOL File: 5394-63-8.mol

Less

2,2,6-Trimethyl-4H-1,3-dioxin-4-one Property

Melting point:: 12-13 °C(lit.)
Boiling point:: ~275 °C(lit.)
Density: 1.07 g/mL at 25 °C(lit.)
refractive index: n20/D 1.460(lit.)
Flash point:: 67 °F
storage temp.: 2-8°C
solubility: water: insoluble
form: Liquid
color: Dark brown
Water Solubility: practically insoluble
BRN: 2408
Exposure limits: ACGIH: TWA 250 ppm; STEL 500 ppm
OSHA: TWA 1000 ppm(2400 mg/m3)
NIOSH: IDLH 2500 ppm; TWA 250 ppm(590 mg/m3)
InChIKey: XFRBXZCBOYNMJP-UHFFFAOYSA-N
CAS DataBase Reference: 5394-63-8(CAS DataBase Reference)

Less

Safety

Hazard Codes: F,Xi
Risk Statements: 11-36/37/38-36
Safety Statements: 16-26-27-36/37/39-9-33
RIDADR: UN 1993 3/PG 2
WGK Germany: 3
HazardClass: 3
PackingGroup: II
HS Code: 29329995

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 691380
Product name: 2,2,6-Trimethyl-4H-1,3-dioxin-4-one
Purity: Lonza quality, ≥93.0% (GC)
Packaging: 25kg
Price: $3240
Updated: 2024/03/01

Sigma-Aldrich

Product number: 691380
Product name: 2,2,6-Trimethyl-4H-1,3-dioxin-4-one
Purity: Lonza quality, ≥93.0% (GC)
Packaging: 180kg
Price: $18930
Updated: 2024/03/01

TCI Chemical

Product number: T1099
Product name: 2,2,6-Trimethyl-1,3-dioxin-4-one
Purity: >95.0%(NMR)
Packaging: 25mL
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: T1099
Product name: 2,2,6-Trimethyl-1,3-dioxin-4-one
Purity: >95.0%(NMR)
Packaging: 500mL
Price: $191
Updated: 2024/03/01

Alfa Aesar

Product number: A14254
Product name: 2,2,6-Trimethyl-1,3-dioxin-4-one, 94%, cont. up to ca 6% acetone
Packaging: 25g
Price: $30.65
Updated: 2024/03/01

Less

2,2,6-Trimethyl-4H-1,3-dioxin-4-one Chemical Properties,Usage,Production

Description

It is usually used as intermediate or raw material in the chemistry synthesis. For example, 2,2,6-Trimethyl-4H-1,3-dioxin-4-one can act as the starting material to produce N-alkenyl acetoacetamides through reaction with imines.¹ This substance can also be involved in the preparation of acetoacetamide derivatives, which result in the formation of the pyrrole amides via oxime of the acetoacetamides.² Moreover, this chemical may be introduced to promote the acetoacetylation of O-(hydroxypropyl)cellulose for generating O-(acetoxypropyl)cellulose.³ In addition, this chemical may be used to yield β-keto esters and β-ketoamides through the reaction with secondary or tertiary alcohols (including chiral ones) or primary or secondary amines.⁴

Reference

Dannibale, A.; Pesce, A.; Resta, S.; Trogolo, C., Reaction of 2,2,6-trimethyl-4H-1,3-dioxin-4-one with imines: An easy route to enamides. Tetrahedron Lett. 1996, 37, 7429-7432.
Huggins, M.; Barber, P.; Florian, D.; Howton, W., Short, Efficient Syntheses of Pyrrole -Amides. Synth. Commun. 2008, 38, 4226-4239.
Pawlowski, W. P.; Gilbert, R. D.; Fornes, R. E.; Purrington, S. T., ACETOACETYLATION OF O-(HYDROXYPROPYL)CELLULOSE BY 2,2,6-TRIMETHYL-4H-1,3-DIOXIN-4-ONE. Carbohydr. Res. 1986, 156, 232-235.
Sridharan, V.; Ruiz, M.; Menendez, J. C., Mild and High-Yielding Synthesis of beta-Keto Esters and beta-Ketoamides. Synthesis 2010, 1053-1057.

Chemical Properties

Dark brown liquid

Uses

Diketene-Acetone Adduct can be used in place of diketene in many reactions. As a transportable form of diketene, it is especially important in those countries, where the transportation of diketene is not allowed or at least not desired.

Uses

2,2,6-Trimethyl-1,3-dioxin-4-one is used in the synthesis of dihydropyrimininones as picomolar sodium iodide symporter inhibitors. It is also used in the synthesis of resorcinol amide Hsp90 Inhibitor AT13387. It is used in the synthesis of acetylketene by flash pyrolysis.

Application

2,2,6-Trimethyl-4H-1,3-dioxin-4-one generates unstable acetylketene together with acetone when heated above 120 ℃. Subsequent condensation with isocyanates, arylcyanates, or substituted cyanamides gives access to a wide range of 1,3-oxazine derivatives. Furthermore, diketene – acetone adduct can also be used for the preparation of a variety of compounds that are not accessible from diketene.

Chemical Reactivity

Diketene – acetone adduct (2,2,6-Trimethyl-4H-1,3-dioxin-4-one) can be regarded as a stabilized form of diketene. It can be safely transported and may conveniently be used instead of diketene in many reactions. For example, it reacts with alcohols and amines to yield acetoacetates and acetoacetamides, respectively. Diketene – acetone adduct generates unstable acetylketene together with acetone when heated above 120 ?C. Subsequent condensation with isocyanates, arylcyanates, or substituted cyanamides gives access to a wide range of 1,3-oxazine derivatives. Furthermore, diketene – acetone adduct can also be used for the preparation of a variety of compounds that are not accessible from diketene.

2,2,6-Trimethyl-4H-1,3-dioxin-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2,2,6-Trimethyl-4H-1,3-dioxin-4-one Suppliers

Australia 1 Belgium 2 Canada 1 China 185 Europe 3 France 1 Germany 7 India 16 Japan 3 Switzerland 5 The Netherlands 1 United Kingdom 10 United States 26 Global 261

Jinan Sanyuan Chemical Co. LTD

Tel: 13335164090
Fax: 0531-58585914
Email: 1660423085@qq.com
Country: China
ProdList: 411
Advantage: 58

BTC Pharmaceutical CO. Ltd

Tel: 0513-0513-68015397 18862996710
Fax: 0513-68015394
Email: sales12@btcpharm.com
Country: China
ProdList: 692
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Beijing Donghualituo Techonlogy Development Co.,Ltd.

Tel: 010-88425576
Fax: (+86)-10-88425546
Email: sales@dhltchem.com
Country: China
ProdList: 793
Advantage: 59

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Changzhou Huanling Chemical Co., Ltd.

Tel: 0519-89803565 13776850645
Fax: 0519-89803575
Email: info4@huanlingchem.com
Country: China
ProdList: 643
Advantage: 68

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19182
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

SpringPharma Tech Co.,Ltd

Tel: +86-25-68710855, +86-25-68710897
Fax: 025-68710856
Email: sales@springpharma.net
Country: China
ProdList: 1261
Advantage: 62

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9478
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 15523000485
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1687
Advantage: 58

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2677
Advantage: 60

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 3970
Advantage: 60

Giant chemicals

Tel: 028-85434334 18108076537
Fax: QQ：245797092
Email: market@gianthx.com
Country: China
ProdList: 4505
Advantage: 56

INTERCHEMIE NANJING PHARMATECH CO., LTD

Tel: 13656237714 13656237714
Fax: 0512-65852853
Email: xiaokunfu@kyyykj.com
Country: China
ProdList: 297
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 17687
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 3495
Advantage: 58

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20806
Advantage: 60

Beijing Tianyukanghong Chemical Technology Co., Ltd.

Tel: 13552605092 13552605092
Fax: 010-60593781
Email: tianyukanghong@163.com
Country: China
ProdList: 343
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 6273
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9999
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13320
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Less

View Lastest Price from 2,2,6-Trimethyl-4H-1,3-dioxin-4-one manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,2,6-Trimethyl-4H-1,3-dioxin-4-one 5394-63-8
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2,2,6-Trimethyl-4H-1,3-dioxin-4-one 5394-63-8
Price: US $100.00-50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

Henan Fengda Chemical Co., Ltd

Product: 2,2,6-Trimethyl-4H-1,3-dioxin-4-one 5394-63-8
Price: US $6.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

5394-63-8, 2,2,6-Trimethyl-4H-1,3-dioxin-4-oneRelated Search:

Mesotrione Trimethyl borate Norgestrel 4-Methyl-2-pentanone Norandrostenedione N-Methyl-2-pyrrolidone Acetone oxime 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN METHYL-2-PYRROLIDONE cis-Cyclooctene 2,2,5,6-TETRAMETHYL-4H-1,3-DIOXIN-4-ONE 2,2,6-Trimethyl-4H-1,3-dioxin-4-one 2,2-DIMETHYL-6-TRIFLUOROMETHYL-1,3-DIOXIN-4-ONE (6R)-(-)-4,10-DIMETHYL-7-ISOPROPYL-1,5-DIOXASPIRO[5.5]UNDEC-3-EN-2-ON 2,6-Bis(4-methoxyphenyl)-2-methyl-4H-1,3-dioxin-4-one SPIRO[ADAMANTANE-2,2'-(6'-(4'-CHLOROPHENYL)-4H-1',3'-DIOXIN-4'-ONE)] 2-(chloromethyl)-2-methyl-6-phenyl-4H-1,3-dioxin-4-one 2-(BROMOMETHYL)-6-(4-METHYLPHENYL)-2-PHENYL-4H-1,3-DIOXIN-4-ONE

Diketton Acetone Adduct

DIKETENE ACETONE ADDUCT

DIKETE ACETONE ADDUCT

2,6,6-TRIMETHYL-1,3-DIOXIN-4-ONE

2,2,6-TRIMETHYL-1,3-DIOXIN-4-ONE: 94%, CONT. UP TO CA 6% ACETONE

2,2,6-TRIMETHYL-1,3-DIOXIN-4-ONE, 94%, CONT. UP TO CA 6% ACE

2,2,6-trimethyl-1,3-dioxine-4H-one

2,2,6-TRIMETHYL-4H-1,3-DIOXIN-4-ONE, TEC H., 85%

2,2,6-TRIMETHYL-1,3-DIOXEN-4-ONE

2,2,6-TRIMETHYL-1,3-DIOXIN-4-ONE

2,2,6-TRIMETHYL-4H-1,3-DIOXIN-4-ONE

2,2,4-TRIMETHYL-6-KETO-1,3-DIOXIN

2,2,6-Trimethyl-1,3-dioxin-4-one, pract.,95%

Trimethyl-(4H)-1,3-dioxin-4-one

2,2,6-Trimethyl-4H-1,3-dioxin-4-one, 90-95%

2,2,6-Trimethyl-4H-1,3-dioxin-

4H-1,3-Dioxin-4-one, 2,2,6-trimethyl-

2,2,6-trimethyl-1,3-dioxolenone

2,2,6-TriMethyl-4H-1,3-dioxin-4-one, 90-95% 100GR

2,2,4-Trimethyl-6-keto-1,3-dioxin Diketene Acetone Adduct

2,2,6-TRIMETHYL-1,3-DIOXINE-4-ONE FOR SY

2,2,6-Trimethyl-4H-1,3-dioxin-4-one, 94%, contains up to 6% acetone

2,2,6-Trimethyl-1,3-dioxine-4-one for synthesis

TKD

2,2,6-TrimethyL

-4H-1,3-dioxin-4-one

2,2,4-Trimethyl-6-keto-1,3-dioxine

212,6-Trinnethy1-4H-1,3- dioxin- 4-one

5394-63-8

Lactones

Carbonyl Compounds

Building Blocks

Organic Building Blocks