CARBONIC ACID DI-2-PYRIDYL ESTER
- Product Name
- CARBONIC ACID DI-2-PYRIDYL ESTER
- CAS No.
- 1659-31-0
- Chemical Name
- CARBONIC ACID DI-2-PYRIDYL ESTER
- Synonyms
- DI-2-PYRIDYL CARBONATE;Dipyridin-2-yl carbonate;2-Pyridinol carbonate;bis(2-pyridyl) carbonate;Carbonicaciddipyridylester;Di-2-pyridyl Carbonate >2-Pyridinol, 2,2'-carbonate;CARBONIC ACID DI-2-PYRIDYL ESTER;DPC Carbonic acid di-2-pyridyl ester;Carbonic acid di-2-pyridyl ester(DPC)
- CBNumber
- CB0422460
- Molecular Formula
- C11H8N2O3
- Formula Weight
- 216.19
- MOL File
- 1659-31-0.mol
CARBONIC ACID DI-2-PYRIDYL ESTER Property
- Melting point:
- 90 °C
- Boiling point:
- 351.6±17.0 °C(Predicted)
- Density
- 1.307
- Flash point:
- 166.438℃
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 0.63±0.12(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- InChI
- InChI=1S/C11H8N2O3/c14-11(15-9-5-1-3-7-12-9)16-10-6-2-4-8-13-10/h1-8H
- InChIKey
- GCSAXWHQFYOIFE-UHFFFAOYSA-N
- SMILES
- C(OC1=NC=CC=C1)(=O)OC1=NC=CC=C1
- CAS DataBase Reference
- 1659-31-0(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C1407
- Product name
- Di-2-pyridyl Carbonate
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- C1407
- Product name
- Di-2-pyridyl Carbonate
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $129
- Updated
- 2025/07/31
- Product number
- D492765
- Product name
- Di-2-pyridyl Carbonate
- Packaging
- 2.5g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- P000288588
- Product name
- Dipyridin-2-yl carbonate
- Purity
- 97%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 076540
- Product name
- Dipyridin-2-yl carbonate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
CARBONIC ACID DI-2-PYRIDYL ESTER Chemical Properties,Usage,Production
Chemical Properties
White to faint yellow crystalline powder
Uses
Di-2-pyridyl carbonate is used as a coupling agent in the esterification of carboxylic acids (e.g. 3-Cyclohexenylcarboxylic acid [C988195]). Di-2-pyridyl carbonate is also used as a reagent to synthesize active carbonates (e.g. benzyl 2-pyridyl carbonate) and carbamates (e.g. 3-Pyridyl diethylcarbamate [P992950]).
Preparation
A solution of phosgene (2.5 m in toluene, 2 mL, 5.0 mmol) was diluted with dichloromethane (8 mL) and then a solution of 2-pyridinol 853 (950 mg, 10 mmol) and triethylamine (1.214 g, 10.2 mmol) in dichloromethane (20 mL) was added at 0 ℃. The reaction mixture was stirred at 0℃ for 1 h, then washed with cold 5% NaHCO3 solution (20 mL) and cold saturated brine (20 mL), dried over MgSO4, and filtered. The filtrate was concentrated to dryness to give di-2-pyridyl carbonate, DPC, 725 (972 mg) in 90% yield. It was recrystallized from dichloromethane/petroleum ether (811 mg, 75%); mp 84–86℃. DPC has also been produced as its hydrochloride salt 877, in a more facile procedure on a larger scale, in 97% yield.
Synthesis
142-08-5
32315-10-9
1659-31-0
(b) Synthesis of di(2-pyridyl) carbonate: Under argon protection, triethylamine (10.5 mL, 75 mmol) was slowly added dropwise to a solution of anhydrous dichloromethane (500 mL) containing triphosgene (3.0 g, 10 mmol) and 2-hydroxypyridine (5.7 g, 60 mmol), keeping the reaction temperature at 0°C. The reaction mixture was then gradually warmed to room temperature and stirred continuously overnight. Subsequently, the reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting residue was dissolved in ethyl acetate (500 mL). The organic phase was washed sequentially with saturated aqueous sodium bicarbonate (2 x 150 mL) and brine (200 mL), and then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated to give an orange colored oil. Crystallization by mixed ethyl acetate/hexane solvent resulted in an off-white crystalline solid of bis(2-pyridyl) carbonate (3.70 g, 57% yield). The nuclear magnetic resonance hydrogen spectrum (1H NMR) data were as follows: δ 8.42 (2H, dd, J = 4.8, 1.1 Hz), 7.83 (2H, ddd, J = 7.8, 7.7, 1.8 Hz), 7.30-7.23 (4H, m).
storage
CARBONIC ACID DI-2-PYRIDYL ESTER is quite stable and can be stored under nitrogen at rt for several months without any noticeable decomposition.
References
[1] Journal of the American Chemical Society, 2004, vol. 126, # 24, p. 7452 - 7453
[2] Patent: US5563151, 1996, A
CARBONIC ACID DI-2-PYRIDYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CARBONIC ACID DI-2-PYRIDYL ESTER manufacturers
- Product
- CARBONIC ACID DI-2-PYRIDYL ESTER 1659-31-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-26
- Product
- Di-2-pyridyl Carbonate 1659-31-0
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2020-01-08
- Product
- CARBONIC ACID DI-2-PYRIDYL ESTER 1659-31-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11