ChemicalBook > CAS DataBase List > 4-(PIPERIDIN-4-YL)-MORPHOLINE

4-(PIPERIDIN-4-YL)-MORPHOLINE

Product Name: 4-(PIPERIDIN-4-YL)-MORPHOLINE
CAS No.: 436099-97-7
Chemical Name: 4-(PIPERIDIN-4-YL)-MORPHOLINE
Synonyms: AKOS BB-9182;CHEMBRDG-BB 4004473;TIMTEC-BB SBB010091;morpholine 2,2,2-trifluoroacetate;4-piperidinium-4-ylmorpholin-4-ium;4-(4-Piperidinyl)Morpholine trifluoroacetate;4-(4-piperidinyl)Morpholine2,2,2-trifluoroacetate;4-(piperidin-4-yl)Morpholine 2,2,2-trifluoroacetate
CBNumber: CB0423548
Molecular Formula: C11H19F3N2O3
Formula Weight: 284.28
MOL File: 436099-97-7.mol

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4-(PIPERIDIN-4-YL)-MORPHOLINE Property

Melting point:: 40-43 °C(lit.)
Boiling point:: 100-115 °C0.15-0.20 mm Hg(lit.)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3533AE
Product name: 4-Piperidin-4-yl-morpholinetrifluoroacetate
Packaging: 250mg
Price: $73
Updated: 2021/12/16

Matrix Scientific

Product number: 008595
Product name: 4-Piperidin-4-yl-morpholinetrifluoroacetate
Packaging: 1g
Price: $378
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0070366
Product name: 4-PIPERIDIN-4-YL-MORPHOLINE TRIFLUOROACETATE
Purity: 95.00%
Packaging: 1G
Price: $672
Updated: 2021/12/16

Ambeed

Product number: A189777
Product name: 4-(Piperidin-4-yl)morpholine2,2,2-trifluoroacetate
Purity: 95%
Packaging: 25g
Price: $404
Updated: 2021/12/16

Chemenu

Product number: CM163198
Product name: 4-Piperidin-4-yl-morpholinetrifluoroacetate
Purity: 95%
Packaging: 10g
Price: $421
Updated: 2021/12/16

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4-(PIPERIDIN-4-YL)-MORPHOLINE Chemical Properties,Usage,Production

Synthesis

76-05-1

53617-35-9

436099-97-7

General procedure for the synthesis of 4-morpholinopiperidine trifluoroacetate from 2,2,2-trifluoroacetic acid and 4-(4-piperidinyl)morpholine: To a stirred solution of tert-butyl 4-oxo-piperidine-1-carboxylate (3.0 g, 15 mmol) in THF (25 mL) were sequentially added morpholine (1.56 g, 18 mmol) and tetraisopropyl titanate (5.58 mL). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, ethanol (15 mL) was added followed by sodium cyanoborohydride (0.63 g, 10.05 mmol). The resulting mixture was stirred at room temperature overnight and the reaction was quenched by the addition of water (4 mL). After continued stirring for 30 min, the white solid was removed by filtration and the filtrate was concentrated by evaporation. The residue was partitioned between ether and water, and the organic layer was separated and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give a white solid. The solid was dissolved in 40 mL of 50% trifluoroacetic acid in dichloromethane solution and stirred at room temperature for 1 hour before removing the solvent. The residue was lyophilized to give the target product 4-morpholinopiperidine trifluoroacetate as a white solid (5.48 g, 98% yield). Mass spectrometry analysis showed that the (M+H)+ peak was located at m/z 171.

References

[1] Patent: US2005/239843, 2005, A1. Location in patent: Page/Page column 15

4-(PIPERIDIN-4-YL)-MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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436099-97-7, 4-(PIPERIDIN-4-YL)-MORPHOLINERelated Search:

4-Morpholinopiperidine 6-MORPHOLINOPYRIDINE-2-CARBOXYLIC ACID 6-MORPHOLINOPYRIDINE-2-CARBALDEHYDE 4-(PIPERIDIN-4-YL)-MORPHOLINE 3-Amino-6-morpholinopyridine (2-MORPHOLINOPYRID-4-YL)METHYLAMINE 4-MORPHOLIN-4-YL-PIPERIDINE-4-CARBOXYLIC ACID 2,6-DIMETHYL-4-PIPERIDIN-4-YL-MORPHOLINE DIHYDROCHLORIDE 4-MORPHOLIN-4-YL-PIPERIDINE-4-CARBOXYLIC ACIDAMIDE 2,6-DIMETHYL-4-PIPERIDIN-4-YL-MORPHOLINEHYDROCHLORIDE 2,6-DIMETHYL-4-PIPERIDIN-4-YL-MORPHOLINE 4-[1-(6-Chloro-pyrimidin-4-yl)-piperidin-4-yl]-morpholine [1-ethyl-4-(2-methylmorpholin-4-yl)piperidin-4-yl]methylamine (1-ethyl-4-morpholin-4-ylpiperidin-4-yl)methylamine 4-PIPERIDIN-4-YL-MORPHOLINETRIFLUOROACETATE (4-morpholin-4-yl-1-propylpiperidin-4-yl)methylamine N-(piperidin-4-yl)morpholine-4-sulfonamide N-(piperidin-3-yl)morpholine-4-sulfonamide

CHEMBRDG-BB 4004473

AKOS BB-9182

TIMTEC-BB SBB010091

4-(piperidin-4-yl)Morpholine 2,2,2-trifluoroacetate

4-(4-Piperidinyl)Morpholine trifluoroacetate

4-(4-piperidinyl)Morpholine2,2,2-trifluoroacetate

morpholine 2,2,2-trifluoroacetate

4-piperidinium-4-ylmorpholin-4-ium

436099-97-7

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