4-Morpholinopiperidine

Product Name: 4-Morpholinopiperidine
CAS No.: 53617-35-9
Chemical Name: 4-Morpholinopiperidine
Synonyms: AKOS BB-9182;CHEMBRDG-BB 4004473;TIMTEC-BB SBB010091;4-Morpholino-piperidin;4-MORPHOLINOPIPERIDINE; Alectinib Impurity 27;4-(4-Piperidyl)morpholine;4-(Morpholin-4-yl)piperidine;4-(4-Piperidinyl) morpholine;Morpholine,4-(4-piperidinyl)-
CBNumber: CB7423547
Molecular Formula: C9H18N2O
Formula Weight: 170.25
MOL File: 53617-35-9.mol

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4-Morpholinopiperidine Property

Melting point:: 40-43 °C(lit.)
Boiling point:: 100-115 °C0.15-0.20 mm Hg(lit.)
Density: 1.033±0.06 g/cm3(Predicted)
vapor pressure: 0.63-4.58Pa at 25-45℃
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: 10.21±0.10(Predicted)
Appearance: Colorless to off-white Solid
InChI: InChI=1S/C9H18N2O/c1-3-10-4-2-9(1)11-5-7-12-8-6-11/h9-10H,1-8H2
InChIKey: YYBXNWIRMJXEQJ-UHFFFAOYSA-N
SMILES: N1(C2CCNCC2)CCOCC1
LogP: 0.3 at 25℃ and pH11
Dissociation constant: 5.44-10.1 at 20℃

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 578045
Product name: 4-Morpholinopiperidine
Purity: 98%
Packaging: 1g
Price: $32.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 578045
Product name: 4-Morpholinopiperidine
Purity: 98%
Packaging: 5g
Price: $66.4
Updated: 2025/07/31

TRC

Product number: P991658
Product name: 4-(Piperidin-4-yl)morpholine
Packaging: 500mg
Price: $75
Updated: 2021/12/16

TRC

Product number: P991658
Product name: 4-(Piperidin-4-yl)morpholine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: P991658
Product name: 4-(Piperidin-4-yl)morpholine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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4-Morpholinopiperidine Chemical Properties,Usage,Production

Uses

Reactant for synthesis of:

Selective adenosine A2A receptor antagonists
Antidepressents
Small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells
Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Quinoline derivatives with antimicrobial activity
Antimalarials

Synthesis

415967-79-2

53617-35-9

General procedure for the synthesis of 4-(4-piperidinyl)morpholine from N-benzyl-4-(4-morpholinyl)piperidine: 41.59 g (0.16 mol) of N-benzyl-4-(4-morpholinyl)piperidine was dissolved in 400 mL of methanol, and 5.2 g of 10% palladium/carbon catalyst was added. The hydrogenation reaction was carried out at room temperature for 18 hours at 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. A colorless oily substance was obtained, which was left to crystallize. The yield was 25.29 g with 93% yield.

References

[1] Patent: US2008/45705, 2008, A1. Location in patent: Page/Page column 10-11
[2] Patent: US2003/69297, 2003, A1
[3] Patent: US2003/125370, 2003, A1

4-Morpholinopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Morpholinopiperidine Suppliers

China 238 Germany 4 India 9 Italy 1 Switzerland 1 Ukraine 1 United Kingdom 3 United States 15 Global 272

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Shanghai Famo Bio-chemical Technology Company Ltd.

Tel: 021-02136680027 15800370750
Email: 1706640024@qq.com
Country: China
ProdList: 570
Advantage: 56

Chengdu aibike Pharmaceutical Technology Co., Ltd

Tel: 028-68517313 13708075524
Email: zhaozhong@emtco.cn
Country: China
ProdList: 27
Advantage: 58

Rushpharm Co.,Ltd.

Tel: 025-66042949 15161141411
Fax: 025-66042949
Email: 2244332520@qq.com
Country: China
ProdList: 55
Advantage: 58

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Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 392
Advantage: 60

Shandong Meiao Huawei Technology Co., LTD

Tel: 0531-88682301 18595278766
Email: yuhongmeng@mayowell.com
Country: China
ProdList: 88
Advantage: 58

J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Sichuan Tongsheng Amino acids Co.,Ltd.

Tel: 0838-2274206 13908101207
Fax: +86-838-2274207
Email: sales@biots.cn
Country: China
ProdList: 279
Advantage: 66

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

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View Lastest Price from 4-Morpholinopiperidine manufacturers

Moxin Chemicals

Product: Alectinib Impurity 27 53617-35-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 1000000
Release date: 2024-12-31

Moxin Chemicals

Product: Alectinib Impurity 53617-35-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000
Release date: 2024-12-16

Nanjing Fred Technology Co., Ltd

Product: 4-(Piperidin-4-yl)morpholine 53617-35-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

53617-35-9, 4-MorpholinopiperidineRelated Search:

Phenylpropyl aldehyde 2,2-Dimorpholinodiethylether 4-Aminopiperidine 4-methylaminopiperidine dihydrochloride (R)-3-Aminopiperidine N-methylpiperidin-3-amine N,N-Dimethylpiperidin-4-amine 4-Piperidinopiperidine Alectinib tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate Phenylpropiolaldehyde 4-(PIPERIDIN-4-YL)-MORPHOLINE 4-Morpholinopiperidine 2,6-DIMETHYL-4-PIPERIDIN-4-YL-MORPHOLINE DIHYDROCHLORIDE 4-MORPHOLIN-4-YL-PIPERIDINE-4-CARBOXYLIC ACIDDIHYDROCHLORIDE 2,6-DIMETHYL-4-PIPERIDIN-4-YL-MORPHOLINE N-(piperidin-4-yl)morpholine-4-sulfonamide 4-[1-(6-Chloro-pyrimidin-4-yl)-piperidin-4-yl]-morpholine

TIMTEC-BB SBB010091

4-(PIPERIDIN-4-YL)-MORPHOLINE

AKOS BB-9182

CHEMBRDG-BB 4004473

4-Morpholino-piperidin

4-(PIPERIDIN-4-YL)-MORPHOLINE >98%

4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE

4-piperidin-4-ylmorpholine(SALTDATA: 2HCl)

4-piperidin-4-ylmorpholine 2HCl

4-(Morpholin-4-yl)piperidine

Morpholine,4-(4-piperidinyl)-

4-(4-Piperidinyl) morpholine

4-(Piperidin-4-yl)-morpholinFree state

4-(4-Piperidyl)morpholine

4-MORPHOLINOPIPERIDINE

TIANFU CHEM---4-(PIPERIDIN-4-YL)-MORPHOLINE

Alectinib Impurity 27

53617-35-9

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