4-Amino-3,5-dichloroacetophenone

ChemicalBook > CAS DataBase List > 4-Amino-3,5-dichloroacetophenone

4-Amino-3,5-dichloroacetophenone

Description Storage

Product Name: 4-Amino-3,5-dichloroacetophenone
CAS No.: 37148-48-4
Chemical Name: 4-Amino-3,5-dichloroacetophenone
Synonyms: 1-(4-amino-3,5-dichlorophenyl)ethan-1-one;1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;5-dichlorophenyl)-;TIMTEC-BB SBB003511;3,5-dichloro-4-amino;Clenbuterol EP Impurity C;4-ACETYL-2,6-DICHLOROANILINE;3, 5-dichloro-4-aminophenone;4-Anubi3,5-dichloroacetophenone;4-AMINO-3,5-DICHLOROACETOPHENONE
CBNumber: CB0423917
Molecular Formula: C8H7Cl2NO
Formula Weight: 204.05
MOL File: 37148-48-4.mol

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4-Amino-3,5-dichloroacetophenone Property

Melting point:: 162-166 °C(lit.)
Boiling point:: 351.5±42.0 °C(Predicted)
Density: 1.2748 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -1.72±0.10(Predicted)
color: Light Tan to Brown
InChI: InChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3
InChIKey: JLPKZJDZXIKSCP-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C
CAS DataBase Reference: 37148-48-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29223990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 536148
Product name: 4′-Amino-3′,5′-dichloroacetophenone
Purity: 97%
Packaging: 25g
Price: $109.2
Updated: 2024/03/01

TCI Chemical

Product number: A1967
Product name: 4'-Amino-3',5'-dichloroacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: A1967
Product name: 4'-Amino-3',5'-dichloroacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $125
Updated: 2024/03/01

TRC

Product number: A604690
Product name: 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone
Packaging: 10g
Price: $230
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17498
Product name: 1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone
Packaging: 100g
Price: $110
Updated: 2021/12/16

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4-Amino-3,5-dichloroacetophenone Chemical Properties,Usage,Production

Description

4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of the antitussive and antiasthmatic drug gramtin.

Storage

4-Amino-3,5-dichloroacetophenone should be stored in a cool, dry place in a small, well filled, well-closed container, protected from light. When a partially filled container is used, the air should be replaced by nitrogen or another inert gas.
4-Amino-3,5-dichloroacetophenone oxidizes on exposure to air, resulting in an increase in the peroxide value.

Chemical Properties

4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.

Uses

4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.

Preparation

4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.

Application

4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.

Application

4-Amino-3,5-dichloroacetophenone has active chemical properties and has been widely used in industrial chemistry, agricultural chemistry, and pharmaceutical chemistry. As a selective oxidant and green coupling reagent, it participates in a variety of oxidation reactions, rearrangement reactions, and amination reactions. In industry, it can also be used as a raw material for the synthesis of drugs, disinfectants, dyes, food seasonings, adhesives, explosives, etc.

4-Amino-3,5-dichloroacetophenone Preparation Products And Raw materials

Raw materials

Acetic acid 4-Aminoacetophenone

Preparation Products

4-Amino-3,5-dichlorophenacylbromide 4-AMINO-ALPHA-TERT-BUTYLAMINE-3,5-DICHLOROACETOPHENONE

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View Lastest Price from 4-Amino-3,5-dichloroacetophenone manufacturers

Dorne Chemical Technology co. LTD

Product: 4-Amino-3,5-dichloroacetophenone 37148-48-4
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

CONTIDE BIOTECH CO.,LTD

Product: 4-Amino-3,5-dichloroacetophenone 37148-48-4
Price: US $0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 20
Release date: 2024-04-15

Shanghai Aosiris new Material Technology Co., LTD

Product: 4-Amino-3,5-dichloroacetophenone 37148-48-4
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-04-16

37148-48-4, 4-Amino-3,5-dichloroacetophenoneRelated Search:

4'-Hydroxyacetophenone 4-Nitroacetophenone 3-Aminoacetophenone Acetyl chloride Dichloroacetonitrile 2-Aminoecetophenone 2-Bromoacetophenone 3-Nitroacetophenone Betaine Glycine ALTRENOGEST L-PICEIN Acetylacetone 4'-Methylacetophenone Acetophenone 4'-DIMETHYLAMINOACETOPHENONE 2',5'-Dichloroacetophenone 3'-DIMETHYLAMINOACETOPHENONE

1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone

1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone

5-AMINO-3,5-DICHLORO ACETOPHENONE

4''-AMINO-3'',5''-DICHLOROACETOPHENONECLENBUTEROL

4-Amino-3,5-dichloroacetophenone,98%

4′-Amino-3′,5′-dichloroacetophenone,1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone

3,5-dichloro-p-aMino acetophenone

4-AMino-3,5-dichloroacetophenone, 98% 5GR

4'-AMino-3',5'-dichloroacetophenone SynonyMs 4-Acetyl-2,6-dichloroaniline

4'-Amino-3',5'-dichloroacetophenone 97%

TIMTEC-BB SBB003511

1-(4-AMINO-3,5-DICHLOROPHENYL)-ETHANONE

4'-AMINO-3',5'-DICHLOROACETOPHENONE

4-AMINO-3,5-DICHLOROACETOPHENONE

4-ACETYL-2,6-DICHLOROANILINE

3,5-DICHLORO-4-AMINOACETOPHENONE

Clenbuterol Impurity 3（Clenbuterol EP Impurity C）

Clenbuterol EP Impurity C

4-Anubi3,5-dichloroacetophenone

1-(4-amino-3,5-dichlorophenyl)ethan-1-one

4-Amino-3,5-dichloroacetophenone CAS: 37148-48-4

CAS 37148-48-4 4-Amino-3,5-dichloroacetophenone

High Quality 4-Amino-3, 5-Dichloroacetophenone

4'-Amino-3',5'-dichloroacetophenone &gt

Ethanone, 1-(4-amino-3,5-dichlorophenyl)-

Bromo-1-Phenyl-Pentan-1-One 2-Bromovalerophenone Yellow Liquid CAS

Pharmaceutical Chemical 2-Bromo-4′-Methylpropiophenone

99% Purity 2-Bromo-1-Phenyl-Pentan-1-One

5-dichlorophenyl)-

3,5-dichloro-4-amino

4-Amino-3,5-dichloroacetophenone Basic information

1-(4-Amino-3,5-dichlorphenyl)ethan-1-on

3, 5-dichloro-4-aminophenone

4'-Amino-3',5'-dichloroacetophenone

37148-48-4

H2NC6H2Cl2COCH3

Organic Building Blocks

Ketones

C7 to C8

Carbonyl Compounds

Building Blocks

Chemical Amines

Amines

Aromatics

Aromatic Acetophenones & Derivatives (substituted)

(intermediate of leflunomide)

37148-48-4