Cianidanol

Product Name: Cianidanol
CAS No.: 154-23-4
Chemical Name: Cianidanol
Synonyms: CATECHIN;D-CATECHIN;Cianidano;(2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol;kb-53;catergen;(2R,3S)-;Catechine;cianidanol;d-catechol
CBNumber: CB0428149
Molecular Formula: C15H14O6
Formula Weight: 290.27
MOL File: 154-23-4.mol

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Cianidanol Property

Melting point:: 175-177 °C (anhydrous)(lit.)
alpha: D18 +16 to +18.4°
Boiling point:: 352.36°C (rough estimate)
Density: 1.2451 (rough estimate)
refractive index: 1.4359 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated, Heated)
form: Solid
pka: 9.54±0.10(Predicted)
color: Light Orange to Light Brown
Merck: 14,1902
InChIKey: PFTAWBLQPZVEMU-DZGCQCFKSA-N
LogP: 0.510
CAS DataBase Reference: 154-23-4
EPA Substance Registry System: 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- (154-23-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: DJ3450000
F: 8-10-23
HS Code: 29329990
Toxicity: LD50 oral in rat: > 10gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 43412
Product name: (+)-Catechin
Purity: analytical standard
Packaging: 10mg
Price: $422
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1096790
Product name: (+)-Catechin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $420
Updated: 2024/03/01

TCI Chemical

Product number: C0705
Product name: (+)-Catechin Hydrate
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $65
Updated: 2021/12/16

TCI Chemical

Product number: C0705
Product name: (+)-Catechin Hydrate
Purity: >97.0%(HPLC)
Packaging: 10g
Price: $340
Updated: 2021/12/16

Sigma-Aldrich

Product number: PHR1963
Product name: (+)-Catechin
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50mg
Price: $302
Updated: 2024/03/01

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Cianidanol Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

procollagen production inhibitoe, hepatoprotectant

Uses

Cianidanol, also known as (+)-catechin; (+)-3,3′4′,5,7-flavanepentol; 3,3′,4′, 5,7-pentahydroxyflavane, [R,3S]-2-[3,4-dihydroxyphenyl]-3,4-dihydro-1[2H]- benzopyran-3,4,7-triol, or 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h- 1-benzopyran-7-triol, is a flavonoid associated with a variety of blood disorders. An association of cianidanol and immune hemolytic anemia and thrombocytopenia has been suggested in numerous case reports. In several reports, the presence of flavonoid-dependent antibodies against red blood cells is evident with cianidanol combining with erythrocyte membranes and inducing development of autoantibodies and antibodies.Several patients had platelet antibodies with increased serum-bindable IgG values without the presence of cianidanol and several with high platelet-associated IgG levels.Antibodies against cianidanol were not detectable in certain cases.The hemolytic anemia caused acute renal failure in some patients and can be life threatening, leading to fatalities. Upon cessation of treatment with cianidanol, hematology appears to return to normal over time.
These side effects do not appear to be specific to cianidanol as the formation of IgE and IgG antibodies to troxerutin (Venoruton) and silymarin (Kegalon) was also evident with patients presenting with fever, skin eruptions, and intravascular hemolysis often demonstrating high IgG titers.Furthermore, cianidanol-induced hemolysis might also occur after sensitization by other flavonoids including rutin.

Uses

Labelled (+)-Catechin (C217500). (+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

Definition

ChEBI: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.

brand name

Ausoliver;Cirramina;Transepar.

World Health Organization (WHO)

Cianidanol, which is extracted from the tropical plant Uncaria gambir, was introduced in 1976 as an adjunct in the treatment of liver disorders. Following a cluster of cases of haemolytic anaemia reported in 1985 from Naples, Italy, four of which were fatal, the company suspended sales worldwide. Although subsequently reintroduced in Switzerland and France for the treatment of acute and chronic hepatitis-B, it was later definitively withdrawn in Switzerland on detailed reassessment and the manufacturer has now withdrawn the product worldwide.

General Description

(+)-Catechin is an important beneficial compound, belonging to the flavonoid class, which is present abundantly in red wine.

Cianidanol Preparation Products And Raw materials

Raw materials

Preparation Products

CACAO PIGMENT

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View Lastest Price from Cianidanol manufacturers

Hebei Longbang Technology Co., Ltd

Product: Cianidanol 154-23-4
Price: US $6.00/kg
Min. Order: 1kg
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-05-13

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Cianidanol; Green tea extract 154-23-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: ≥98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-28

HebeiShuoshengImportandExportco.,Ltd

Product: Cianidanol 154-23-4
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-09

154-23-4, CianidanolRelated Search:

2-Phenylphenol Tetrahydro-4H-pyran-4-one Hydroxy silicone oil Catechol Tetrahydropyran Triphenylphosphine Tea polyphenol Procyanidin (+/-)-Catechin hydrate Silibinin Dihydromyricetin L-Epicatechin Silicristin (-)-CATECHIN GALLATE (-)-CATECHIN HYDRATE Procyanidin B1 (-)-Epigallocatechin Phenylacetone

(+)-CATECHIN

CATECHIN

CATECHIN, (+)-

D-CATECHIN

(+)-3,3'4',5,7-FLAVANEPENTOL

3,3',4',5,7-PENTAHYDROXYFLAVANE

[2R,3S]-2-[3,4-DIHYDROXYPHENYL]-3,4-DIHYDRO-1[2H]-BENZOPYRAN-3,4,7-TRIOL

2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h-1-benzopyran-7-triol

5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R-trans)-2H-1-Benzopyran-3

catechin(flavan)

catechinicacid

catechol(flavan)

catechuicacid

catergen

cianidanol

d-catechol

kb-53

2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol (2R,3S)

(2R,3S)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol

CATECHIN 85%

(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

(+)-CATECHIN WITH HPLC

2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-

Catechin，Cianidanol，Cyanidol

(+)-Cyanidan-3-ol

2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)-

Cyanidanol

(2R,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol

CATECHIN, (+)-(AHP)(CALL)

(2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol

Cianidano

(+)-Catechin 154-23-4

(+)-Catechin, froM green tea

(+)-Catechin (25 mg)

Catechin(C)

(2R,3S)-

(+)-Catechin-d3

Biocatechin

Cianidanol, Dexcyanidanol

Drenoliver

Tanningenic acid

Cianidanol,(+)-Catechin hydrate

Cianidanol(EGCG)

(+)-Cyanidol-3 (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyra3,5,7-triol

(+)-Catechin, 99%, from green tea

(+)-Catechin Standard

(+)-Catechin Hydrate&gt

Cianidanol Solution, 100μg/mL

Cianidanol USP/EP/BP

(+)-catechin

(+)-Catechin (1096790)

Catechine

(+)-Catechin C

(+)-Catechin (25 mg)

(+)-Catechin-RM

154-23-4

15-23-4

Flavonoids