ChemicalBook > CAS DataBase List > Neocuproine

Neocuproine

Product Name: Neocuproine
CAS No.: 484-11-7
Chemical Name: Neocuproine
Synonyms: 2,9-DIMETHYL-1,10-PHENANTHROLINE;DMPHEN;Mephen;2,9-Dimethylphenanthroline;2,9-Dimethyl-o-phenanthroline;VUF 7738;NEOCUPROINE;Cuproin,neo;Neo-Cuproin;2,9-DimethyL
CBNumber: CB0429520
Molecular Formula: C14H12N2
Formula Weight: 208.26
MOL File: 484-11-7.mol

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Neocuproine Property

Melting point:: 159-164 °C
Boiling point:: 337.46°C (rough estimate)
Density: 1.1345 (rough estimate)
bulk density: 280kg/m3
refractive index: 1.6152 (estimate)
RTECS: SF8380000
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: methanol: 0.1 g/mL, clear
form: crystalline
pka: 6.01±0.30(Predicted)
color: white to beige
Water Solubility: slightly soluble
Sensitive: Light Sensitive
Merck: 6449
InChIKey: IYRGXJIJGHOCFS-UHFFFAOYSA-N
CAS DataBase Reference: 484-11-7(CAS DataBase Reference)
NIST Chemistry Reference: 1,10-Phenanthroline, 2,9-dimethyl-(484-11-7)
EPA Substance Registry System: 1,10-Phenanthroline, 2,9-dimethyl- (484-11-7)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22-22
Safety Statements: 26-36/37/39-36-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1501
Product name: Neocuproine
Purity: ≥98%
Packaging: 1g
Price: $37.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: N1501
Product name: Neocuproine
Purity: ≥98%
Packaging: 5g
Price: $111
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1.02968
Product name: Neocuproine
Purity: GR for analysis
Packaging: 5G
Price: $350
Updated: 2025/07/31

Cayman Chemical

Product number: 20874
Product name: Neocuproine
Purity: ≥98%
Packaging: 5g
Price: $54
Updated: 2024/03/01

Cayman Chemical

Product number: 20874
Product name: Neocuproine
Purity: ≥98%
Packaging: 10g
Price: $94
Updated: 2024/03/01

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Neocuproine Chemical Properties,Usage,Production

Chemical Properties

Neocuproine is a off-white to very pale yellow crystalline powder, in the presence of reducing agents it reacts with copper to give a copper(I) complex of composition MA2 and of tetrahedral symmetry.

Uses

Due to the steric hindrance of the methyl groups attached to the carbon atoms adjacent to the nitrogen donor atoms of phenanthroline, the reagent does not give the low spin vivid red complex characteristic of phenanthroline derivatives with iron(II). However, in the presence of reducing agents it reacts with copper to give a copper(I) complex of composition MA2 and of tetrahedral symmetry. This chelate is insoluble in water and can be extracted by chloroform in which the absorption maximum of the complex appears at 457 nm. In this way the concentration of the complex can be measured. The method is suitable for the determination of copper in iron, manganese and vanadium ores even in the presence of aluminium, germanium, titanium and silicon.
Neocuproine is today considered one of the most selective reagents. Unfortunately, it is rather expensive. 2,3-bis-(2-pyridyl)quinoxaline, prepared by Belcher et al. by condensation of o-diketone, 2,2'-dipyridyl and 0-phenylenediamine(44) contains the functional grouping characteristic of cuproine; it is quite suitable for the determination of copper and it is cheap. Starting with various substituted o-phenylene-diamines Belcher synthesized 25 different quinoxaline derivatives, of which 2,3-bis-[2-(-methyl)-pyridyl)]quinoxaline proved to be identical with neocuproine as regards analytical selectivity. Besides copper, titanium(III) is the only metal ion which gives a colour reaction with the reagent. However, the coloured titanium(III) complex is formed only at lower pH and hence it does not interfere with the determination of copper. The copper complex of the reagent can be extracted quantitatively with isopentyl alcohol usually as a perchlorate ion pair.

Uses

Neocuproine is a phenanthroline based metal ion chelating agent.

Definition

ChEBI: A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9.

Purification Methods

Purifiy it as the hemihydrate by crystallisation from water and as the anhydrous base from *benzene. [Beilstein 23/8 V 527.]

Neocuproine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Neocuproine manufacturers

Shanghai UCHEM Inc.

Product: 2,9-Dimethyl-1,10-phenanthroline 484-11-7
Price: US $12.00-104.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 10kg
Release date: 2025-09-23

Watson Biotechnology Co.,Ltd

Product: Neocuproine 484-11-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-12-20

Honest Joy Holdings Limited

Product: Neocuproine 484-11-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-02-18

484-11-7, NeocuproineRelated Search:

Dimethyl sulfone ETHANE Dimethyl sulfide Dimethyl sulfate Dimethyl sulfoxide Dimethyl ether Sodium diethyldithiocarbamate N,N-Dimethylaniline Dimethyl fumarate Dacthal Dimethyl sebacate N,N-Dimethylformamide Dimethyl carbonate o-Phenanthroline Dichlorodimethylsilane 1,7-PHENANTHROLINE N,N-Dimethylacetamide Poly(dimethylsiloxane)

TIMTEC-BB SBB008718

NEOCUPROINE REAG

NEOCUPROINE

10-Phenanthroline,2,9-dimethyl-1

2,9-dimethyl-10-phenanthroline

2,9-Dimethyl-o-phenanthroline

2,9-Dimethylphenanthroline

2,9 DiMethy 1,10-phenanthrofine

Neocuproine, 99+% 5GR

NEOCUPROINE GR FOR ANALYSIS 5 G

2,9- twoMethyl -1,10-phen

2,9-Neocuproine

VUF 7738

Cuproin,neo

2,9-dimethyl-1,10-phenanthroline,98%

Neocuproine hemihydrate,2,9-Dimethyl-1,10-phenanthroline

Neocuproine,2,9-Dimethyl-1,10-phenanthroline

Neocuproine Hemihydr

Mephen

Neocuproine, 98.5%

DMPHEN

Neocuproine Vetec(TM) reagent grade, 98%

2,10-diMethyl-1,9-phenanthroline

Neocuproine HeMihydrat

Neo-Cuproin

Neocuproin,hemihydrate

2,9-DIMETHYL-1,10-PHENANTHROLINE

neocuproine free base

Neocuproine,98%

NEOCUPROIN HEMIHYDRATE R. G.

NeocuproineGr

Neocuproine, 99+%

NEOCUPROINE,REAGENT

2,9-DIMETHYL-1,10-PHENANTHROLINE REAGENT (ACS)

1,10-Phenanthroline, 2,9-dimethyl-

2,9-DIMETHYL-1,10-PHENANTHROLINE, REAGENT (ACS)2,9-DIMETHYL-1,10-PHENANTHROLINE, REAGENT (ACS)2,9-DIMETHYL-1,10-PHENANTHROLINE, REAGENT (ACS)2,9-DIMETHYL-1,10-PHENANTHROLINE, REAGENT (ACS)

Neocuproine, 98.5%, reagent grade

2,9-DimethyL

ine hemihydrate

-1,10-phenanthroL

Neocuproin hemihydrate, Reag.

Neocuproine, 95%+

Neocuproine, GR 99%+

Neocuproine (2,9-Dimethyl-1,10-phenanthroline) extrapure, 99%

3-Dihydroflavone

Neocuproine、2,9-Dimethyl-1,10-phenanthroline hemihydrate

Neocuproine 99% AR

484-11-7

C14H12N212H2O

CH32C12H6N2

C14H12N205H2O

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