Boc-L-Tyr(tBu)-OH

ChemicalBook > CAS DataBase List > Boc-L-Tyr(tBu)-OH

Product Name: Boc-L-Tyr(tBu)-OH
CAS No.: 47375-34-8
Chemical Name: Boc-L-Tyr(tBu)-OH
Synonyms: BOC-TYR(TBU)-OH;Boc-Tyr(tBu);BOC-L-TYR(TBU)-OH;BOC-TYR(BUT)-OH;Boc-Tyr(tBul)-OH;TIMTEC-BB SBB006926;BOC-TYROSINE(TBU)-OH;Boc-Tyr(tBu)-OH 100g;Boc-Tyr(tBu)-OH, 99.0%;BOC-O-T-BUTYL-L-TYROSINE
CBNumber: CB0434634
Molecular Formula: C18H27NO5
Formula Weight: 337.41
MOL File: 47375-34-8.mol

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Boc-L-Tyr(tBu)-OH Property

Melting point:: 113-118 °C
alpha: -15 º (C=1% IN DMF)
Boiling point:: 484.0±40.0 °C(Predicted)
Density: 1.116±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder to crystal
pka: 3.00±0.10(Predicted)
color: White to Almost white
optical activity: [α]20/D 15.0±1.0°, c = 1% in DMF
Water Solubility: Soluble in DMF. Insoluble in water.
BRN: 4327336
InChI: InChI=1S/C18H27NO5/c1-17(2,3)23-13-9-7-12(8-10-13)11-14(15(20)21)19-16(22)24-18(4,5)6/h7-10,14H,11H2,1-6H3,(H,19,22)(H,20,21)/t14-/m0/s1
InChIKey: ZEQLLMOXFVKKCN-AWEZNQCLSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 47375-34-8(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53023
Product name: Boc-Tyr(tBu)-OH
Purity: Novabiochem?
Packaging: 5G
Price: $194
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.53023
Product name: Boc-Tyr(tBu)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $764
Updated: 2024/03/01

TCI Chemical

Product number: B3485
Product name: N-(tert-Butoxycarbonyl)-O-tert-butyl-L-tyrosine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $29
Updated: 2024/03/01

TCI Chemical

Product number: B3485
Product name: N-(tert-Butoxycarbonyl)-O-tert-butyl-L-tyrosine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $86
Updated: 2024/03/01

Alfa Aesar

Product number: H62801
Product name: N-Boc-O-tert-butyl-L-tyrosine, 98%
Packaging: 5g
Price: $122.65
Updated: 2024/03/01

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Boc-L-Tyr(tBu)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-O-tert-butyl-L-tyrosine (Boc-L-Tyr(tBu)-OH) is used as pharmaceutical intermediate.

Application

Boc-Tyr(tBu)-OH is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. This compound could be used as a starting material to synthesize TPE-Tyr. TPE-Tyr can undergo covalent crosslinking via the formation of dityrosine linkages by exploiting horseradish peroxidase (HRP)-catalyzed phenol polymerization in the presence of H2O2, thereby activating the AIE process and switching on fluorescence emission of TPE core motif[1].

Synthesis

O-tert-butyl-L-tyrosine (2.00 g, 8.42 mmol, 1.0 equiv.) and di-tert-butyl dicarbonate (2.20 g, 10.10 mmol, 1.2 equiv.) were dissolved in a mixture of THF (15 mL) and NaOH (1 N, 30 mL) and stirred at room temperature for 10 h. THF was removed under reduced pressure, and the pH of residual solution was adjusted to 3.0 with dilute hydrochloric acid and the crude product was extracted by ethyl acetate. The combined organic phases was washed with saturated brine (pH 3.0) and dried over anhydrous Na2SO4. The organic solvent was removed under reduced pressure and dried in a vacuum oven at room temperature overnight, affording (N-Boc-O-tert-butyl)-L-Tyr (Boc-O-tert-butyl-L-tyrosine) as a yellowish solid (2.64 g, 93%)[1].

References

[1] Wang X, et al. Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission. Journal of the American Chemical Society, 2014; 136: 9890–9893.

Boc-L-Tyr(tBu)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-L-Tyr(tBu)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Tyr(tBu)-OH 47375-34-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: Boc-O-tert-butyl-L-tyrosine 47375-34-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: Boc-O-tert-butyl-L-tyrosine 47375-34-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500KG
Release date: 2018-08-19

47375-34-8, Boc-L-Tyr(tBu)-OHRelated Search:

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BOC-0-tert-butyl-L-tyrosine

47375-34-8

CH33COC6H4CH2CHCOOHNHCOOCCH33

C18H27NO5

CARBOXYLIC ACID

Peptide Synthesis

Specialty Synthesis

Tyrosine

Amino Acid Derivatives

Boc-Amino Acids and Derivative

Boc-Amino acid series

Amino Acids