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Boc-L-Tyr(tBu)-OH

Product Name
Boc-L-Tyr(tBu)-OH
CAS No.
47375-34-8
Chemical Name
Boc-L-Tyr(tBu)-OH
Synonyms
BOC-TYR(TBU)-OH;Boc-Tyr(tBu);BOC-L-TYR(TBU)-OH;BOC-TYR(BUT)-OH;Boc-Tyr(tBul)-OH;TIMTEC-BB SBB006926;BOC-TYROSINE(TBU)-OH;Boc-Tyr(tBu)-OH 100g;Boc-Tyr(tBu)-OH, 99.0%;BOC-O-T-BUTYL-L-TYROSINE
CBNumber
CB0434634
Molecular Formula
C18H27NO5
Formula Weight
337.41
MOL File
47375-34-8.mol
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Boc-L-Tyr(tBu)-OH Property

Melting point:
113-118 °C
alpha 
-15 º (C=1% IN DMF)
Boiling point:
484.0±40.0 °C(Predicted)
Density 
1.116±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder to crystal
pka
3.00±0.10(Predicted)
color 
White to Almost white
optical activity
[α]20/D 15.0±1.0°, c = 1% in DMF
Water Solubility 
Soluble in DMF. Insoluble in water.
BRN 
4327336
InChI
InChI=1S/C18H27NO5/c1-17(2,3)23-13-9-7-12(8-10-13)11-14(15(20)21)19-16(22)24-18(4,5)6/h7-10,14H,11H2,1-6H3,(H,19,22)(H,20,21)/t14-/m0/s1
InChIKey
ZEQLLMOXFVKKCN-AWEZNQCLSA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference
47375-34-8(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53023
Product name
Boc-Tyr(tBu)-OH
Purity
Novabiochem?
Packaging
5G
Price
$194
Updated
2024/03/01
Sigma-Aldrich
Product number
8.53023
Product name
Boc-Tyr(tBu)-OH
Purity
Novabiochem?
Packaging
25g
Price
$764
Updated
2024/03/01
TCI Chemical
Product number
B3485
Product name
N-(tert-Butoxycarbonyl)-O-tert-butyl-L-tyrosine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B3485
Product name
N-(tert-Butoxycarbonyl)-O-tert-butyl-L-tyrosine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$86
Updated
2024/03/01
Alfa Aesar
Product number
H62801
Product name
N-Boc-O-tert-butyl-L-tyrosine, 98%
Packaging
5g
Price
$122.65
Updated
2024/03/01
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Boc-L-Tyr(tBu)-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-O-tert-butyl-L-tyrosine (Boc-L-Tyr(tBu)-OH) is used as pharmaceutical intermediate.

Application

Boc-Tyr(tBu)-OH is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. This compound could be used as a starting material to synthesize TPE-Tyr. TPE-Tyr can undergo covalent crosslinking via the formation of dityrosine linkages by exploiting horseradish peroxidase (HRP)-catalyzed phenol polymerization in the presence of H2O2, thereby activating the AIE process and switching on fluorescence emission of TPE core motif[1].

Synthesis

O-tert-butyl-L-tyrosine (2.00 g, 8.42 mmol, 1.0 equiv.) and di-tert-butyl dicarbonate (2.20 g, 10.10 mmol, 1.2 equiv.) were dissolved in a mixture of THF (15 mL) and NaOH (1 N, 30 mL) and stirred at room temperature for 10 h. THF was removed under reduced pressure, and the pH of residual solution was adjusted to 3.0 with dilute hydrochloric acid and the crude product was extracted by ethyl acetate. The combined organic phases was washed with saturated brine (pH 3.0) and dried over anhydrous Na2SO4. The organic solvent was removed under reduced pressure and dried in a vacuum oven at room temperature overnight, affording (N-Boc-O-tert-butyl)-L-Tyr (Boc-O-tert-butyl-L-tyrosine) as a yellowish solid (2.64 g, 93%)[1].

References

[1] Wang X, et al. Highly Selective Fluorogenic Multianalyte Biosensors Constructed via Enzyme-Catalyzed Coupling and Aggregation-Induced Emission. Journal of the American Chemical Society, 2014; 136: 9890–9893.

Boc-L-Tyr(tBu)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-L-Tyr(tBu)-OH Suppliers

Americas 1 China 166 Europe 3 Germany 5 India 3 Japan 3 Switzerland 2 United Kingdom 9 United States 30 Global 222
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23680
Advantage
75
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View Lastest Price from Boc-L-Tyr(tBu)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Tyr(tBu)-OH 47375-34-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
Boc-O-tert-butyl-L-tyrosine 47375-34-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
Boc-O-tert-butyl-L-tyrosine 47375-34-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

47375-34-8, Boc-L-Tyr(tBu)-OHRelated Search:

tert-Butanol tert-Butyl hydroperoxide tert-Butyl methyl ether BUTYL OLEATE 4-tert-Butylcatechol L-Tyrosine Cyhalofop-butyl 4-tert-Butylphenol Boc-Aib-OH Boc-D-Tyr-OH tert-Butyldimethylsilyl chloride Buprofezin Methyl 4-tert-butylbenzoate TYROSINASE Dibutyl phthalate BOC-GLY-LEU-OH Boc-Tyr(Me)-OH O-METHYL-D-TYROSINE

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  • 47375-34-8
  • CH33COC6H4CH2CHCOOHNHCOOCCH33
  • C18H27NO5
  • CARBOXYLIC ACID
  • Peptide Synthesis
  • Specialty Synthesis
  • Tyrosine
  • Amino Acid Derivatives
  • Boc-Amino Acids and Derivative
  • Boc-Amino acid series
  • Amino Acids