ChemicalBook > CAS DataBase List > CEPHALOTAXINE

CEPHALOTAXINE

Product Name: CEPHALOTAXINE
CAS No.: 24316-19-6
Chemical Name: CEPHALOTAXINE
Synonyms: NSC 245454;NSC 128487;Cephalotaxin;Cephalotaxlen;ZINC19795976);(-)-Cephalotaxine;CEPHALOTAXINE USP/EP/BP;Cephalotaxine 24316-19-6;Cephalotaxine hydrochloride;Cephalotaxlen (ZINC19795976)
CBNumber: CB0435666
Molecular Formula: C18H21NO4
Formula Weight: 315.36
MOL File: 24316-19-6.mol

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CEPHALOTAXINE Property

Melting point:: 131-132 °C(Solv: benzene (71-43-2))
Boiling point:: 495.2±45.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: DMF: 10 mg/mL; DMSO: 12 mg/mL; Ethanol: 5 mg/mL
form: powder to crystal
pka: 13.30±0.40(Predicted)
color: White to Orange to Green
CAS DataBase Reference: 24316-19-6

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 3
HS Code: 2939.79.0000
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3641
Product name: Cephalotaxine
Packaging: 25MG
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: C3641
Product name: Cephalotaxine
Packaging: 100MG
Price: $155
Updated: 2025/07/31

TRC

Product number: C261050
Product name: Cephalotaxine
Packaging: 250mg
Price: $240
Updated: 2021/12/16

TRC

Product number: C261050
Product name: Cephalotaxine
Packaging: 100mg
Price: $130
Updated: 2021/12/16

TRC

Product number: C261050
Product name: Cephalotaxine
Packaging: 25mg
Price: $55
Updated: 2021/12/16

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CEPHALOTAXINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Antiviral and antitumor agent.

Definition

ChEBI: A benzazepine alkaloid isolated from Cephalotaxus harringtonia.

Synthesis

38750-57-1

24316-19-6

Sodium borohydride (27 mg, 0.70 mmol, 40 eq.) was added to a stirred solution of (-)-cephathione (S9) (5.5 mg, 18 μmol, 1.0 eq.) in methanol (0.65 mL) at -78 °C. The resulting white mixture was continued to be stirred at -78 °C for 10 minutes, followed by a slow warming to 25 °C and stirring at this temperature for 1 hour. Upon completion of the reaction, the mixture was diluted with water (30 mL) and extracted with dichloromethane (4 x 15 mL). The organic phases were combined, dried with sodium sulfate, gravity filtered, and the filtrate was concentrated by rotary evaporation to afford the target product (-)-1 (5.2 mg, 95% yield) as a light yellow film. Thin layer chromatography (TLC) showed an Rf value of 0.08 (unfolding agent: 10% methanol/dichloromethane). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3), IR and HRMS (ESI): 1H NMR δ 6.68 (s, 1H, ArH), 6.65 (s, 1H, ArH), 5.90 (s, 2H, OCH2O), 4.93 (s, 1H, vinyl H), 4.76 (d, 1H, J = 9Hz, CH(OH )), 3.73 (s, 3H, OCH3), 3.68 (d, 1H, J = 9 Hz, ArCHCH(OH)), 3.35 (m, 1H, CH2), 3.08 (m, 1H, CH2), 2.92 (dd, 1H, J = 12, 11, 7 Hz, CH2), 2.54-2.62 (m, 2H, CH2), 2.36 (ddd, 1H, J = 14, 7Hz, CH2), 2.00 (m, 1H, CH2), 1.60-1.90 (m, 4H, CH2); IR (pure film) 3411 (broad peaks, weak), 2926 (medium), 1651 (medium), 1503 (medium), 1486 (strong), 1222 (strong) cm-1; HRMS (ESI) m/z: C18H22NO4 ([M+H]+) calculated value 316.1549, measured value 316.1559.

References

[1] Journal of the American Chemical Society, 2006, vol. 128, # 32, p. 10370 - 10371
[2] Chemistry - A European Journal, 2008, vol. 14, # 14, p. 4293 - 4306
[3] Patent: WO2009/148654, 2009, A2. Location in patent: Page/Page column 135
[4] Phytochemistry (Elsevier), 1973, vol. 12, p. 2987 - 2991

CEPHALOTAXINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CEPHALOTAXINE manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: CEPHALOTAXINE 24316-19-6
Price: US $0.00-0.00/mg
Min. Order: 20mg
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2022-10-21

Shanghai Standard Technology Co., Ltd.

Product: Cephalotaxine 24316-19-6
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-13

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Cephalotaxine 24316-19-6 24316-19-6
Price: US $22.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-03

24316-19-6, CEPHALOTAXINERelated Search:

Cephalomannine N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine Acetylcephalotaxine Drupacine 2-(Benzo[d][1,3]dioxol-5-yl)ethanol Mephentermine 3-AMINO-3-METHYL-BUTAN-1-OL pentorex PHENTERMINE HARRINGTONINE CEPHALOTAXINE (+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE 1-(3,4-Methylenedioxyphenyl)-2-butanamine 1-(1,3-BENZODIOXOL-5-YL)PROPAN-2-AMINE 1-Methyl-2-pyrrolidineethanol 4-(4-METHOXYPHENYL)-1-BUTENE 3-AMINO-5-HYDROXY-PENTEN-1 cyclopent-2-en-1-ol

(3aR)-2-Methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-ol

[1S-(1a,3aS*,14b)]-1,5,6,8,9,14b-Hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol

NSC 128487

NSC 245454

CEPHALOTAXINE FROM CEPHALOTAXUS &

Cephalotaxin

Cephalotaxlen ((-)-Cephalotaxine

ZINC19795976)

(1S,3aR,14bβ)-1,5,6,8,9,14b-Hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1α-ol

(4R)-7,8-(Methylenebisoxy)-3,4-(trimethylene)-4β,5β-[(3S)-2-methoxy-3-hydroxypropene-1,3-diyl]-1,2,4,5-tetrahydro-3H-3-benzoazepine

Cephalotaxlen

(2S,3S,6R)-4-Methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^{2,6}.0^{6,10}.0^{15,19}]icosa-1(20),4,13,15(19)-tetraen-3-ol

[1S-(1α,3aS*,14bβ)]-1,5,6,8,9,14b-Hexahydro-2-Methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol

Cephalotaxine hydrochloride

Cephalotaxine 24316-19-6

(1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-ol

CEPHALOTAXINE USP/EP/BP

Cephalotaxlen (ZINC19795976)

(-)-Cephalotaxine

Inhibitor,Cephalotaxine,ZINC 19795976,Influenza Virus,ZINC-19795976,inhibit

(11bS,12S,14aR)-13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-ol

Cephalotaxine, 10 mM in DMSO

24316-19-6

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