2-(Benzo[d][1,3]dioxol-5-yl)ethanol

Product Name: 2-(Benzo[d][1,3]dioxol-5-yl)ethanol
CAS No.: 6006-82-2
Chemical Name: 2-(Benzo[d][1,3]dioxol-5-yl)ethanol
Synonyms: Homopiperonyl alcohol;1,3-Benzodioxole-5-ethanol;2-(1,3-BENZODIOXOL-5-YL)ETHANOL;3,4-METHYLENEDIOXYPHENYL-1-ETHANOL;5-(2-Hydroxyethyl)-1,3-benzodioxole;2-(1,3-Benzodioxol-5-yl)ethanol 97%;2-(3,4-Methylenedioxyphenyl)ethanol;2-(benzo[d][1,3]dioxol-5-yl)ethanol;2-(2H-1,3-Benzodioxol-5-yl)ethan-1-ol;3,4-(METHYLENEDIOXY)PHENETHYL ALCOHOL
CBNumber: CB2688462
Molecular Formula: C9H10O3
Formula Weight: 166.17
MOL File: 6006-82-2.mol

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2-(Benzo[d][1,3]dioxol-5-yl)ethanol Property

Boiling point:: 115-117
Density: 1.269±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 14.87±0.10(Predicted)
Appearance: Light yellow to yellow Liquid

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B115013
Product name: 2-(2H-1,3-benzodioxol-5-yl)ethan-1-ol
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 064063
Product name: 2-(2H-1,3-Benzodioxol-5-yl)ethan-1-ol
Purity: 95+%
Packaging: 500mg
Price: $262
Updated: 2021/12/16

Matrix Scientific

Product number: 064063
Product name: 2-(2H-1,3-Benzodioxol-5-yl)ethan-1-ol
Purity: 95+%
Packaging: 1g
Price: $328
Updated: 2021/12/16

AK Scientific

Product number: 6478AE
Product name: 2-(2H-1,3-Benzodioxol-5-yl)ethan-1-ol
Packaging: 2.5g
Price: $714
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0018474
Product name: 2-(1,3-BENZODIOXOL-5-YL)ETHANOL
Purity: 95.00%
Packaging: 500MG
Price: $720.84
Updated: 2021/12/16

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2-(Benzo[d][1,3]dioxol-5-yl)ethanol Chemical Properties,Usage,Production

Synthesis

2861-28-1

6006-82-2

6.2.1 Synthesis of 2-(1,3-benzodioxol-5-yl)ethanol (21) [9]. A solution of anhydrous THF (10 mL) with acid 20 (3.00 mmol) was slowly added dropwise to a suspension of anhydrous THF (20 mL) with lithium aluminum hydride (0.114 g, 3.00 mmol) over 15 min. After 4 h of reaction, methanol (1 mL) and 10% NaOH aqueous solution (2 mL) were added sequentially to quench the excess reducing agent until aluminum hydroxide precipitate was formed. Subsequently, the reaction mixture was neutralized with 10% aqueous hydrochloric acid solution (about 5 mL). The resulting mixture was extracted with ethyl acetate (3 x 15 mL), and the combined organic phases were washed with brine, concentrated under reduced pressure, and dried over anhydrous sodium sulfate. The residue was purified by silica gel column chromatography (eluent: CHCl3/EtOH = 100:1) to afford the target product, sterol 21, as a yellow oil in a yield of 0.489 g (98%). Thin layer chromatography (TLC) Rf = 0.5 (CHCl3/EtOH = 20:1). IR (thin film, cm-1): 3351, 2883, 1607, 1503, 1489, 1442, 1247, 1040. 1H NMR (CDCl3): δ 1.87 (br, 1H, ArCH2CH2OH); 2.76 (t, J = 6.5 Hz, 2H, ArCH2CH2OH); 3.78 (t, J = 6.5 Hz, 2H, ArCH2CH2OH); 5.91 (s, 2H, OCH2O); 6.65 (dd, J = 7.8 Hz, J = 1.6 Hz, 1H, 4'); 6.71-6.70 (m, 1H, 2'); 6.75 (d, J = 7.8 Hz, 1H, 5').13C NMR (CDCl3): δ 38.6 (ArCH2CH2OH); 63.5 (ArCH2CH2OH); 100.6 (OCH2O); 108.1 (CH, 2'); 109.1 (CH, 5'); 121.7 (CH, 6'); 132.0 (C, 1'); 145.9 (CH, 4'); 147.5 (CH, 3').

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 22, p. 3333 - 3340
[2] Patent: US6342610, 2002, B2. Location in patent: Page column 121
[3] European Journal of Medicinal Chemistry, 2016, vol. 122, p. 601 - 610
[4] Tetrahedron Letters, 1997, vol. 38, # 25, p. 4347 - 4350
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 14, p. 4618 - 4627

2-(Benzo[d][1,3]dioxol-5-yl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Benzo[d][1,3]dioxol-5-yl)ethanol Suppliers

Belgium 1 China 39 Germany 2 India 1 Switzerland 1 United Kingdom 8 United States 8 Global 60

J & K SCIENTIFIC LTD.

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Thermo Fisher Scientific

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9ding chemical ( Shanghai) Limited

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Amadis Chemical Company Limited

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9ding chemical ( Shanghai) Limited

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Aikon International Limited

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Shanghai Haohong Pharmaceutical Co., Ltd.

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SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

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