ChemicalBook > CAS DataBase List > RHOEADINE

RHOEADINE

Product Name
RHOEADINE
CAS No.
2718-25-4
Chemical Name
RHOEADINE
Synonyms
rhoeadin;rheadine;RHOEADINE;Brn 0098745;(+)-Rheadine;Rheadine (8ci);RHODIZONIC ACID Dihydrate(RG);8β-Methoxy-16-methyl-2,3:10,11-bis[methylenebis(oxy)]rheadan;8-beta-methoxy-16-methyl-2,3:10,11-bis(methylenebis(oxy))rheadan;3:10,11-bis(methylenebis(oxy))-8-methoxy-16-methyl-(8-beta)-rheada
CBNumber
CB5435166
Molecular Formula
C21H21NO6
Formula Weight
383.4
MOL File
2718-25-4.mol
More
Less

RHOEADINE Property

Melting point:
222°C
alpha 
D23 +235° (c = 1.01 in chloroform); D22 +174° (c = 0.69 in pyridine)
Boiling point:
510.32°C (rough estimate)
Density 
1.3202 (rough estimate)
refractive index 
1.5614 (estimate)
pka
6.40±0.40(Predicted)
Water Solubility 
832.6mg/L(25 ºC)
LogP
3.920 (est)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
R317500
Product name
(+)-Rheadine
Packaging
10mg
Price
$4125
Updated
2021/12/16
TRC
Product number
R317500
Product name
(+)-Rheadine
Packaging
25mg
Price
$4950
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48577
Product name
(+)-Rheadine
Packaging
25mg
Price
$5500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0032094
Product name
RHOEADINE
Purity
95.00%
Packaging
25MG
Price
$5775
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48577
Product name
(+)-Rheadine
Packaging
10mg
Price
$4750
Updated
2021/12/16
More
Less

RHOEADINE Chemical Properties,Usage,Production

Description

This alkaloid was found by Hesse in Papaver rhoeas Linn (red poppy) and its reputed existence in opium now appears doubtful. The base crystallizes from a mixture of CHCl3 and Et20 and sublimes at 21 5-225°C/0.02 mm. It has [α]17.5D + 232° (CHCI 3) or [α]19D + 243° (CHCl3). It behaves as a weak base and is sparingly soluble in H20, alkaline solutions and most organic solvents. It dissolves in mineral acids giving an intensely red solution but investigation shows that only a small proportion of the alkaloid is used to produce the colour, the major part being converted into a colourless, crystalline substance, Rhoeagenine, a much stronger base, non-volatile, and stable to acids. This base is not isomeric with the alkaloid as first thought but has the formula C2oH1906N, m.p. 236-8°C; [α]19D + l68° (AcOH).).
Rhoeadine itself contains two methylenedioxy groups, one methoxy group and an N-methyl group. The salts are not easy to prepare but a crystalline hydriodide dihydrate is formed by addition of KI to a solution of the alkaloid in AcOH. The ultraviolet spectrum of the alkaloid shows absorption maxima at 205, 240 and 292 mμ.

Uses

An isoquinoline alkaloid used in the therapeutic field particularly for the prevention and the treatment of pathologies implying a central and/or peripheral disorder.

Uses

As an isoquinoline alkaloid, Rhoeadine can be used in the therapeutic field particularly for the prevention and the treatment of pathologies implying a central and/or peripheral disorder.

Definition

ChEBI: Rhoeadine is an alkaloid.

References

Hesse., Annalen, Suppl., 4, 50 (1S65)
Hesse., ibid, 140, 145 (1S66)
Spath., Monatsh., 68,33 (1936)
Awe., Arch. Pharm., 279,116 (1941)
Santavy etat., Collect. Czech. Chem. Commun., 30,335,3479 (1965)
Mass spectrum:
Dolejs, Hanus., Tetrahedron, 23, 2997 (1967)
Stereochemistry:
Shamma et at., Chem. Commun., 212 (1968)

RHOEADINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

RHOEADINE Suppliers

Canada 1 China 16 Germany 2 India 1 United Kingdom 5 United States 6 Global 31
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8899
Advantage
60
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30240
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58

2718-25-4, RHOEADINERelated Search:

Isochroman 2-(Benzo[d][1,3]dioxol-5-yl)ethanol Phenylephrine INETERMEDIATE OF GALANTHAMINE 1 (R)-(-)-1-AMINO-1-PHENYL-2-METHOXYETHANE 4-CHLORO-2-FLUOROBENZYLAMINE HYDROCHLORIDE dioxethedrin (R)-4-(1-Aminoethyl)phenol (S)-hydroxybutanedioate salt 1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL Norepinephrine RHOEADINE etafedrine Synephrine (S)-(-)-1-(4-Methoxyphenyl)ethylamine 1-(1,3-BENZODIOXOL-5-YL)PROPAN-2-AMINE 1-(1,3-benzodioxol-5-yl)propan-1-amine (1R,2R)-(+)-2-AMINO-1,2-DIPHENYLETHANOL 2,2'-DIMETHYLBIBENZYL

  • 3:10,11-bis(methylenebis(oxy))-8-methoxy-16-methyl-(8-beta)-rheada
  • 8-beta-methoxy-16-methyl-2,3:10,11-bis(methylenebis(oxy))rheadan
  • rheadine
  • rhoeadin
  • RHOEADINE
  • (5bR,13bR,15S)-5b,6,7,8,13b,15-Hexahydro-15-Methoxy-6-Methyl-[1,3]dioxolo[4,5-h]-1,3-dioxolo[7,8][2]benzopyrano[3,4-a][3]benzazepine
  • 8β-Methoxy-16-methyl-2,3:10,11-bis[methylenebis(oxy)]rheadan
  • Brn 0098745
  • Rheadan, 8-methoxy-16-methyl-2,3:10,11-bis(methylenebis(oxy))-, (8-beta)-
  • Rheadine (8ci)
  • RHODIZONIC ACID Dihydrate(RG)
  • [1,3]Dioxolo[4,5-h]-1,3-dioxolo[7,8][2]benzopyrano[3,4-a][3]benzazepine, 5b,6,7,8,13b,15-hexahydro-15-methoxy-6-methyl-, (5bR,13bR,15S)-
  • (+)-Rheadine
  • 2718-25-4
  • Amines
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Alkaloids