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BUTYRONITRILE

Product Name
BUTYRONITRILE
CAS No.
109-74-0
Chemical Name
BUTYRONITRILE
Synonyms
BUTANENITRILE;PROPYL CYANIDE;N-BUTYRONITRILE;butanonitrile;n-C3H7CN;NITRILE C4;1-Cyanpropan;Propylkyanid;BUTYRONITRILE;Butyromitrile
CBNumber
CB0436355
Molecular Formula
C4H7N
Formula Weight
69.11
MOL File
109-74-0.mol
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BUTYRONITRILE Property

Melting point:
−112 °C(lit.)
Boiling point:
115-117 °C(lit.)
Density 
0.794 g/mL at 25 °C(lit.)
vapor density 
2.4 (vs air)
vapor pressure 
23 mm Hg ( 25 °C)
refractive index 
n20/D 1.384(lit.)
Flash point:
62 °F
storage temp. 
Flammables area
solubility 
slightly soluble in water; soluble in alcohol, ether and dimethylformamide
form 
Liquid
color 
Clear
explosive limit
1.6% (v/v)
Water Solubility 
Miscible with benzene, alcohol, ether and dimethylformamide. Slightly soluble in water.
Merck 
14,1597
BRN 
1361452
Exposure limits
TLV-TWA 22.5 mg/m3 (8 ppm) (NIOSH).
Dielectric constant
20.7(21℃)
Stability:
Stable. Combustible. Substances to be avoided include strong acids, strong bases, strong oxidizing agents and strong reducing agents.
LogP
0.401 at 30℃
CAS DataBase Reference
109-74-0(CAS DataBase Reference)
EPA Substance Registry System
Butanenitrile (109-74-0)
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Safety

Hazard Codes 
T,F
Risk Statements 
10-23/24/25-11
Safety Statements 
45-63-36/37-16
RIDADR 
UN 2411 3/PG 2
OEB
A
OEL
TWA: 8 ppm (22 mg/m3)
WGK Germany 
1
RTECS 
ET8750000
Autoignition Temperature
910 °F
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29269095
Hazardous Substances Data
109-74-0(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 0.14 g/kg (Smyth)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H330Fatal if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
20760
Product name
Butyronitrile
Purity
purum, ≥99.0% (GC)
Packaging
250ML
Price
$68.3
Updated
2024/03/01
Sigma-Aldrich
Product number
20760
Product name
Butyronitrile
Purity
purum, ≥99.0% (GC)
Packaging
1L
Price
$100
Updated
2024/03/01
TCI Chemical
Product number
B0768
Product name
Butyronitrile
Purity
>99.0%(GC)
Packaging
25mL
Price
$20
Updated
2023/06/20
TCI Chemical
Product number
B0768
Product name
Butyronitrile
Purity
>99.0%(GC)
Packaging
500mL
Price
$74
Updated
2023/06/20
Alfa Aesar
Product number
L02999
Product name
Butyronitrile
Purity
99%
Packaging
250ml
Price
$35
Updated
2023/06/20
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BUTYRONITRILE Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Chemical Properties

n-Butyronitrile has a sharp suffocating odor. Forms cyanide in the body. Butyronitrile [109-74-0], propyl cyanide, butanenitrile, CH3(CH2)2CN, is a colorless liquid slightly miscible with water, miscible with ethanol and diethyl ether. The physical properties are listed in Table 1. Butyronitrile is usually obtained by the catalytic gase-phase reaction of butanol or butyraldehyde with ammonia. Its major use is the manufacture of the poultry drug amprolium.

Uses

Basic material in industrial, chemical, and pharmaceutical intermediates and products; poul- try medicines.

Uses

Butyronitrile serves as an intermediate in the chemical and pharmaceutical industries. It is also involved in the preparation of n-butylamine, butanamide and butyric acid. It acts as a precursor to the poultry drug amprolium. Further, it reacts with phosphorochloridic acid diethyl ester to prepare (1-cyano-propyl)-phosphonic acid diethyl ester. It is also employed to study the effect of stereochemical factors on intervalence charge transfer. In addition to this, it is used in electrolyte composition in dye-sensitized solar cells.

Uses

Butyronitrile is used as a chemical intermediate.

Definition

ChEBI: A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a propyl group.

Production Methods

n-Butyronitrile is prepared from 1-butanol by controlled cyanation with NH3 at 300°C in the presence of Ni-Al203 or zinc phosphide catalysts.

General Description

A clear colorless liquid. Flash point 76°F. Less dense than water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used in the manufacture of other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

BUTYRONITRILE can react vigorously with oxidizing reagents, when heated to decomposition, BUTYRONITRILE emits highly toxic fumes of cyanides and oxides of nitrogen [Sax, 9th ed., 1996, p. 609]. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

Hazard

Flammable, dangerous fire risk.

Health Hazard

n-Butyronitrile is considered a highly hazardous material and full precautions should be used to prevent skin contact or inhalation of the vapor. Inhaled n-butyronitrile is about 2.4 times as toxic as acetonitrile. In order to protect workers, the recommended TWA limit is obtained by dividing that for acetonitrile by the factor 2.4. NIOSH has therefore recommended that employee exposure should not exceed 8 ppm (v/v) (22 mg/m3) compound as a TLV-TWA.

Health Hazard

Butyronitrile showed moderate to high toxicity on test animals. It is an acute toxicant by all routes: inhalation, ingestion, and absorption through skin. The target organs are the liver, kidney, central nervous system, lungs, and sense organs, as well as the peripheral nerve. Its toxicity is on the same order as that of propionitrile; its inhalation toxicity is slightly lower than that of propionitrile, and its oral toxicity is slightly greater than that of propionitrile.
Inhalation can cause nausea, respiratory distress, and damage to liver. Willhite (1981) reported a LC50 value of 249 ppm in mice from 1 hour exposure to its vapor. It produced ataxia, dyspnea, and corneal damage in test animals when given intraperitoneally. The toxic symptoms from subcutaneous applications are tremor, dyspnea, respiratory depression, and spastic paralysis. It is toxic only at low levels by skin absorption.
LD50 value, oral (mice): 27.7 mg/kg
There is no report on its teratogenicity. The reproductive effect of this compound is expected to be similar to that of propionitrile.

Health Hazard

Dizziness, rapid respirations, headache, drowsiness, drop in blood pressure and pulse, delayed symptoms. May cause cyanosis (blue-grey coloring of skin and lips due to lack of oxygen)

Fire Hazard

Special Hazards of Combustion Products: Toxic cyanide fumes

Flammability and Explosibility

Highly flammable

Industrial uses

n-Butyronitrile is used as an industrial solvent, an intermediate in the chemical industry and in poultry medicines.

Safety Profile

A poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. Moderately toxic by inhalation. Experimental reproductive data. A skin irritant. Dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx and CN-.

Purification Methods

Treat it with conc HCl until the smell of the isonitrile had gone, then dry with K2CO3 and fractionally distil [Turner J Chem Soc 1681 1956]. Alternatively it is twice heated at 75o and stirred for several hours with a mixture of 7.7g Na2CO3 and 11.5g KMnO4 per L of butyronitrile. The mixture is cooled, then distilled. The middle fraction is dried over activated alumina. [Schoeller & Wiemann J Am Chem Soc 108 22 1986, Beilstein 2 IV 806.]

Waste Disposal

Burning in a chemical incinerator equipped with an afterburner and scrubber is the most effective way to destroy the compound. Oxidation with ethanolic–KOH can convert butyronitrile to nonhazardous cyanate.

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BUTYRONITRILE Suppliers

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