Description Chemical Properties Indications Uses References
ChemicalBook > CAS DataBase List > Dyclonine hydrochloride

Dyclonine hydrochloride

Description Chemical Properties Indications Uses References
Product Name
Dyclonine hydrochloride
CAS No.
536-43-6
Chemical Name
Dyclonine hydrochloride
Synonyms
DYCLONINE;DYCLONINE HCL;tanaclone;s154;p-267;c5422;diclonia;DYCLONLNE;dyclothane;Dycloninae
CBNumber
CB0439886
Molecular Formula
C18H28ClNO2
Formula Weight
325.87
MOL File
536-43-6.mol
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Dyclonine hydrochloride Property

Melting point:
175-176°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (20 mg/ml); Water (25 mg/ml)
form 
solid
color 
White
Water Solubility 
Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol.
Merck 
14,3473
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
InChI
InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H
InChIKey
KNZADIMHVBBPOA-UHFFFAOYSA-N
SMILES
C1(C(=O)CCN2CCCCC2)C=CC(OCCCC)=CC=1.Cl
CAS DataBase Reference
536-43-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
UG8750000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1230000
Product name
Dyclonine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$381
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1849
Product name
Dyclonine hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$108
Updated
2022/05/15
TCI Chemical
Product number
D4303
Product name
Dyclonine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$86
Updated
2024/03/01
TCI Chemical
Product number
D4303
Product name
Dyclonine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$250
Updated
2024/03/01
Alfa Aesar
Product number
J61330
Product name
Dyclonine hydrochloride
Packaging
25g
Price
$282.65
Updated
2024/03/01
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Dyclonine hydrochloride Chemical Properties,Usage,Production

Description

Dyclonine hydrochloride is the hydrochloride salt of Dyclonine. Dyclonine belongs to a kind of oral anaesthetic. It is contained in the “Sucrets” as well as some kinds of Cepacol sore throat spray as an active ingredient. Dyclonine takes effect through reversibly binding to the activated sodium channels located on the neuronal membrane. This decreases the permeability of sodium across the neuronal membrane, further increasing the threshold for excitation. Overall, Dyclonine stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and further suppressing the subsequent conduction. This causes a transient and reversible anaesthetic effect in a local area of the body.

Chemical Properties

Dyclonine hydrochloride is a white crystalline powder possessing topical anesthetic properties characterized by rapid onset of effect, lack of systemic toxicity and a low index of sensitization.

Indications

Dyclonine hydrochloride is a ketone derivative without an ester or amide linkage that may be used in patients who are allergic to the common anesthetics. Dyclonine offers advantages over other topical anesthetic agents.Extensive experience with the topical preparation has shown it to be effective and safe. As a topical anesthetic, dyclonine hydrochloride is available by prescription, and to patients it is available over-the-counter in Sucrets lozenges.
Classification: Ketone.
Available concentration: Formulated for use in dentistry as a 0.5% or 1% solution.
Onset of action: Slow; may take up to 10 minutes to become effective. Duration: Average duration of 30 minutes; however, effects may last up to 1 hour.
Maximum recommended dose: 200 mg (40 mL of 0.5% solution or 20 mL of a 1% solution).
Metabolism/excretion: No information is available on the metabolism and excretion of dyclonine hydrochloride.
Pregnancy/lactation: FDA Category C/Caution is recommended during lactation.

Uses

Dyclonine hydrochloride is used for the temporary relief of the following occasional mouth and throat symptoms: pain, minor irritation, sore mouth and sore throat. It is a sodium channel blocker and a HSP90 chaperone protein inhibitor. It shows local anesthetic effects in vivo and is orally active.

References

https://en.wikipedia.org/wiki/Dyclonine
https://pubchem.ncbi.nlm.nih.gov/compound/Dyclonine_hydrochloride#section=Top

Description

Dyclonine (536-43-6) is a? topical anesthetic which has been used for oral and throat analgesia.1 Enhances neuronal mitochondrial function, potentiating respiration and providing protection against insults associated with neurodegenerative disorders.2 Inhibits aldehyde dehydrogenase ALDH3A1 resulting in accumulation of 4-hydroxynonenal, which renders head and neck squamous cell carcinoma cells sensitive to the cystine-glutamate antiporter inhibitor, sulfasalazine.3 Rescues frataxin deficiency in animal models as well as in buccal cells of patients with Friedreich’s Ataxia.4 Enhances the cytotoxic effect of proteasome inhibitors MG-1325 and bortezomib6 in cancer cells.

Chemical Properties

White Crystalline Solid

Originator

Dyclone,Dow,US,1956

Uses

Provides anesthesia of mucous membranes. Apply 5 to 10 minutes before a procedure; apply b.i.d. to t.i.d. for pain relief. Onset of action is within 2 to 10 minutes. Anesthesia lasts 30 to 60 minutes.

Uses

anesthetic (topical)

Uses

Used as a local anesthetic

Uses

Dyclonine hydrochloride is used for the temporary relief of the following occasional mouth and throat symptoms: pain, minor irritation, sore mouth and sore throat. It is a sodium channel blocker and a HSP90 chaperone protein inhibitor. It shows local anesthetic effects in vivo and is orally active.

Definition

ChEBI: The hydrochloride salt of dyclonine.

Manufacturing Process

A mixture of 17.6 grams of p-n-butoxyacetophenone, 12.1 grams of piperidine hydrochloride, 4.5 grams paraformaldehyde, 0.25 cc concentrated hydrochloric acid, 52.5 cc nitroethane, 7.5 cc of 95% ethanol, and 15 cc of toluene was boiled under reflux for one hour, removing water formed in the reaction by means of a condensate trap. The mixture was then cooled. The crystals which formed were collected by filtration, washed with anhydrous ether and recrystallized from methyl ethyl ketone. The crystals thus obtained, which melted at 174-175°C, were shown by analysis to be 4-n-butoxy-β- piperidinopropiophenone hydrochloride.

brand name

Dyclone (AstraZeneca).

Therapeutic Function

Local anesthetic

References

Groeben et al. (2001), Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics: a comparison of lidocaine, ropivacaine, and dyclonine; Anesthesiology, 94 423 Boglarka et al. (2020), High-Throughput Small Molecule Screen Identifies Modulators of Mitochondrial Function in Neurons; iScience, 23 100931 Okazaki et al. (2018), Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells; Oncotarget, 9 33832 Sahdeo et al. (2014), Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedriech’s ataxia; Hum. Mol. Genet., 23 6848 Ju et al. (2009), Dyclonine and alverine citrate enhance the cytotoxic effects of proteasome inhibitor MG132 on breast cancer cells; J. Mol. Med., 23 205 Ju et al. (2014), Dyclonine enhances the cytotoxic effect of proteasome inhibitor bortezomib in multiple myeloma cells; Mol. Med. Rep., 10 2609

Dyclonine hydrochloride Preparation Products And Raw materials

Raw materials

Sodium bromide

Preparation Products

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View Lastest Price from Dyclonine hydrochloride manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Dyclonine hydrochloride 536-43-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2024-12-20
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dyclonine Hydrochloride 536-43-6
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-17
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Dyclonine hydrochloride 536-43-6
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-15

536-43-6, Dyclonine hydrochlorideRelated Search:

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