(S)-(+)-TETRAHYDROFURFURYL ALCOHOL
- Product Name
- (S)-(+)-TETRAHYDROFURFURYL ALCOHOL
- CAS No.
- 57203-01-7
- Chemical Name
- (S)-(+)-TETRAHYDROFURFURYL ALCOHOL
- Synonyms
- 102205;(2S)-oxolan-2-yl]methanol;(S)-TETRAHYDROFURFURYLALCOHOL;(S)-(+)-TETRAHYDROFURFURYL ALCOHOL;2-FuranMethanol, tetrahydro-, (2S)-;(R)-(-)-2-(Hydroxymethyl)tetrahydrofuran;(R)-(-)-2-(Hydroxymethyl)tetrahydrofurane;(2S)-(+)-2-(Hydroxymethyl)tetrahydrofuran;(S)-(+)-TETRAHYDROFURFURYL ALCOHOL ISO 9001：2015 REACH;(2S)-(+)-(Tetrahydrofur-2-yl)methanol, (S)-(+)-Tetrahydrofurfuryl alcohol
- CBNumber
- CB0448756
- Molecular Formula
- C5H10O2
- Formula Weight
- 102.13
- MOL File
- 57203-01-7.mol
(S)-(+)-TETRAHYDROFURFURYL ALCOHOL Property
- Boiling point:
- 176.8±8.0 °C(Predicted)
- Density
- 1.038±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- liquid
- pka
- 14.44±0.10(Predicted)
- color
- Clear, colourless
- CAS DataBase Reference
- 57203-01-7
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T294085
- Product name
- (S)-(Tetrahydrofuran-2-yl)methanol
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- T294085
- Product name
- (S)-(Tetrahydrofuran-2-yl)methanol
- Packaging
- 500mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 2H01-1-04
- Product name
- (2S)-(+)-2-(Hydroxymethyl)tetrahydrofuran
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- OR40670
- Product name
- (2S)-(+)-2-(Hydroxymethyl)tetrahydrofuran
- Purity
- 96%
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
- Product number
- CCH0001213
- Product name
- 2-FURANMETHANOL, TETRAHYDRO-, (2S)-
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $223.65
- Updated
- 2021/12/16
(S)-(+)-TETRAHYDROFURFURYL ALCOHOL Chemical Properties,Usage,Production
Uses
(S)-(Tetrahydrofuran-2-yl)methanol is used during aminopyrrolopyrimidine derivatives preparation and IGF-1R inhibition in tumors.
Synthesis
87392-05-0
97-99-4
Under argon protection, (R)-tetrahydrofuran-2-carboxylic acid (2 g, 17.22 mmol) was dissolved in 20 mL of tetrahydrofuran (THF) and the reaction flask was cooled in an ice bath. Borane-dimethyl sulfide complex (BH3-SMe2, 2M THF solution, 10 mL, 20.0 mmol) was slowly added to the reaction solution over 10 min. After removing the ice bath, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was again cooled in an ice bath and methanol was slowly added until no gas escaped. Finally, the reaction solution was concentrated under reduced pressure to afford the target product tetrahydrofurfuryl alcohol as an oil (1 g, 60% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 1.55-1.70 (m, 1H), 1.72-1.98 (m, 3H), 3.35-4.00 (m, 6H).
References
[1] European Journal of Organic Chemistry, 2001, # 23, p. 4537 - 4542
[2] Patent: WO2016/16238, 2016, A1. Location in patent: Page/Page column 184
[3] Patent: WO2017/134188, 2017, A1. Location in patent: Page/Page column 48; 49
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 15, p. 2830 - 2841
[5] Journal of Organic Chemistry, 1997, vol. 62, # 2, p. 242 - 243
(S)-(+)-TETRAHYDROFURFURYL ALCOHOL Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(+)-TETRAHYDROFURFURYL ALCOHOL Suppliers
- Tel
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
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View Lastest Price from (S)-(+)-TETRAHYDROFURFURYL ALCOHOL manufacturers
- Product
- (S)-(+)-TETRAHYDROFURFURYL ALCOHOL 57203-01-7
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 5kg ,50kg
- Release date
- 2020-01-08