ChemicalBook > CAS DataBase List > N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- Product Name
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- CAS No.
- 314054-00-7
- Chemical Name
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- Synonyms
- C-176;STING inhibitor 1;C-176 STING inhibitor;N-(4-iodophenyl)-5-nitro-2-furamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
- CBNumber
- CB04522191
- Molecular Formula
- C11H7IN2O4
- Formula Weight
- 358.09
- MOL File
- 314054-00-7.mol
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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Property
- Boiling point:
- 361.2±37.0 °C(Predicted)
- Density
- 1.935±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO (up to 25 mg/ml)
- pka
- 11.14±0.70(Predicted)
- form
- solid
- color
- Brown or yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2559
- Product name
- C-176
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $97.7
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML2559
- Product name
- C-176
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $237
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25859
- Product name
- C-176
- Packaging
- 10mg
- Price
- $40
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25859
- Product name
- C-176
- Packaging
- 50mg
- Price
- $170
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25859
- Product name
- C-176
- Packaging
- 25mg
- Price
- $90
- Updated
- 2024/03/01
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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Chemical Properties,Usage,Production
Description
C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation?via?blockade of palmitoylation at Cys91. Treatment of Trex-/-?mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.
storage
Store at -20°C
References
1)Haag?et al.?(2018),?Targeting STING with covalent small-molecule inhibitors; Nature?559?269
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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