4-Iodopyrazole

Product Name: 4-Iodopyrazole
CAS No.: 3469-69-0
Chemical Name: 4-Iodopyrazole
Synonyms: 4-IODO-1H-PYRAZOLE;4-IODOPYRAZOLE;4-Lodophrazole;4-LODO PYRAZOLE;4-iodopyrazole 4-;4-Iodopyrazole>4-IODOPYRAZOLE 99%;4-Iodopyrazole ,98%;4 - iodine pyrazole;4-Iodopyrazole, 97+%
CBNumber: CB0456472
Molecular Formula: C3H3IN2
Formula Weight: 193.97
MOL File: 3469-69-0.mol

More

Less

4-Iodopyrazole Property

Melting point:: 108-110 °C (lit.)
Boiling point:: 291.9±13.0 °C(Predicted)
Density: 2.335±0.06 g/cm3(Predicted)
RTECS: UQ7145000
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 12.99±0.50(Predicted)
form: Crystalline Powder
color: White to off-white
Water Solubility: Soluble in water.
Sensitive: Light Sensitive
InChI: InChI=1S/C3H3IN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
InChIKey: LLNQWPTUJJYTTE-UHFFFAOYSA-N
SMILES: N1C=C(I)C=N1
CAS DataBase Reference: 3469-69-0(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29331990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 213993
Product name: 4-Iodopyrazole
Purity: 99%
Packaging: 10g
Price: $91.3
Updated: 2025/07/31

TCI Chemical

Product number: I0692
Product name: 4-Iodopyrazole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: I0692
Product name: 4-Iodopyrazole
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $186
Updated: 2025/07/31

TRC

Product number: I719470
Product name: 4-Iodopyrazole
Packaging: 100g
Price: $745
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y15229
Product name: 4-Iodopyrazole
Purity: 98%
Packaging: 5g
Price: $5
Updated: 2021/12/16

More

Less

4-Iodopyrazole Chemical Properties,Usage,Production

Chemical Properties

White or off-white solid

Uses

4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.

Uses

4-Iodopyrazole was used in an indium-mediated synthesis of heterobiaryls.

Definition

ChEBI: 4-iodopyrazole is a member of pyrazoles and an organoiodine compound.

General Description

4-Iodopyrazole is a valuable intermediate for the synthesis of biologically active compounds. It undergoes iodination in the presence of iodine and ammonium hydroxide to yield 3,4-di-iodo- and 3,4,5-tri-iodo-pyrazole.

Synthesis

288-13-1

3469-69-0

The general procedure for the synthesis of 4-iodopyrazole from pyrazole is as follows: Example 1: Preparation of 2-amino-3-methyl-5-(1-methyl-1H-pyrazol-4-yl)-5-(3-pyrimidin-5-ylphenyl)-3,5-dihydro-4H-imidazol-4-one Step a): Preparation of compound 2 A mixture of pyrazole (3.00 g, 44.0 mmol), iodine (6.71 g, 26.4 mmol) and ceric ammonium nitrate (14.5 g, 26.4 mmol) in acetonitrile (400 mL) was stirred at room temperature for 2.5 hours. Upon completion of the reaction, the mixture was concentrated and partitioned between ethyl acetate (250 mL) and 5% aqueous sodium bisulfite (250 mL). After addition of water (150 mL), the organic layer was separated, washed with brine (250 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to afford compound 2 (7.80 g, 91% yield) as a white solid with a melting point of 105-108 °C. 1H NMR (300 MHz, CDCl3) δ 7.63 (s, 2H).

References

[1] Tetrahedron Letters, 2001, vol. 42, # 5, p. 863 - 865
[2] Heterocycles, 2003, vol. 60, # 4, p. 879 - 886
[3] Journal of Organic Chemistry, 2003, vol. 68, # 21, p. 8075 - 8079
[4] Tetrahedron Letters, 2001, vol. 42, # 11, p. 2089 - 2092
[5] Russian Chemical Bulletin, 2014, vol. 63, # 2, p. 360 - 367

4-Iodopyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Iodopyrazole Suppliers

Americas 1 Canada 1 China 368 Europe 2 France 1 Germany 4 Hungary 1 India 28 Japan 3 Switzerland 2 Ukraine 1 United Kingdom 11 United States 45 Global 468

Nanjing YiFan Biological Technology Co., Ltd.

Tel: 025-025-52700520 18914499889
Fax: 025-52700520
Email: sales@yfbiotech.com
Country: China
ProdList: 495
Advantage: 58

LEADMEDPHARM CO.,LTD

Tel: 13674959855 13674959855
Email: sales@synthontech.com
Country: China
ProdList: 3035
Advantage: 58

Changzhou Standard Chemicals Ltd.

Tel: 0519-85607885 13776800733
Fax: +86 519 8552788
Email: email@standardschem.com
Country: China
ProdList: 114
Advantage: 62

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Bridge Organics

Tel: +1269-649-4200
Fax: +1269-649-0611
Email: ab@bridgeorganics.com
Country: United States
ProdList: 162
Advantage: 55

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

More

Less

View Lastest Price from 4-Iodopyrazole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4-Iodopyrazole 3469-69-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-28

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Iodopyrazole 3469-69-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Iodopyrazole 3469-69-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

3469-69-0, 4-IodopyrazoleRelated Search:

Pyrazole Pyraclostrobin Zolpidem tartrate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Zolpidem 4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE 3,5-DIMETHYL-4-IODO-1H-PYRAZOLE,3,5-DIMETHYL-4-IODOPYRAZOLE 1-(BENZYLOXY)-4-IODOPYRAZOLE 1-ACETYL-4-IODO-1H-PYRAZOLE,acetyl-4-iodo-1H-pyrazole 3,4-Diiodopyrazole 1-Phenyl-4-iodopyrazole 2-Phenyl-1,5-dimethyl-4-iodo-1H-pyrazole-3(2H)-one 3-Methyl-4-iodopyrazole benzyl-4-iodo-1H-pyrazole,1-BENZYL-4-IODO-1H-PYRAZOLE,1H-(N-BENZYL)-4-IODOPYRAZOLE 5-IODO-1H-PYRAZOLE TERT-BUTYL 4-IODOPYRAZOLE-1-CARBOXYLATE,1-BOC-4-IODOPYRAZOLE,T-BUTYL 4-IODO-1H-PYRAZOLE-1-CARBOXYLATE 1-METHYL-4-IODO-1H-PYRAZOLE (4-IODO-3-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID

4-IODOPYRAZOLE

4-IODO-1H-PYRAZOLE

1H-PYRAZOLE, 4-IODO-

4-Iodo-1H-pyrazole 99%

Crizotinib Impurity 14

4-IODOPYRAZOLE 99%

4-Iodopyrazole ,98%

4-Lodophrazole

4-LODO PYRAZOLE

4-Iodopyrazole, 97+%

4-Iodopyrazole 4-Iodo-1H-pyrazole

4 - iodine pyrazole

4-iodopyrazole 4-

4-Iodopyrazole&gt

4-Iodopyrazole, 98%, for synthesis

3469-69-0

33469-69-0

3469-69-1

C3H3N2I

C3H3IN2

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrazoles

HALOGEN

Halides

Pyrazoles & Triazoles

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrazoles

PyrazolesHeterocyclic Building Blocks

Azoles

blocks

Iodides