4-CHLORO-6-FLUOROQUINAZOLINE
- Product Name
- 4-CHLORO-6-FLUOROQUINAZOLINE
- CAS No.
- 16499-61-9
- Chemical Name
- 4-CHLORO-6-FLUOROQUINAZOLINE
- Synonyms
- uoroquinazoL;4-CHLORO-6-FLUOROQUINAZOLINE;Quinazoline, 4-chloro-6-fluoro-;4-Chloro-6-fluoroquinazoline?New
- CBNumber
- CB0456917
- Molecular Formula
- C8H4ClFN2
- Formula Weight
- 182.58
- MOL File
- 16499-61-9.mol
4-CHLORO-6-FLUOROQUINAZOLINE Property
- Boiling point:
- 284.9±20.0 °C(Predicted)
- Density
- 1.447±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 0.17±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C8H4ClFN2/c9-8-6-3-5(10)1-2-7(6)11-4-12-8/h1-4H
- InChIKey
- XIKGISGZFBCGDW-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(F)C=C2)=C(Cl)N=C1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- HazardClass
- IRRITANT
- HS Code
- 2933992000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C384945
- Product name
- 4-Chloro-6-fluoroquinazoline
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C384945
- Product name
- 4-Chloro-6-fluoroquinazoline
- Packaging
- 250mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 3H44-7-07
- Product name
- 4-Chloro-6-fluoroquinazoline
- Packaging
- 250mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 057317
- Product name
- 4-Chloro-6-fluoroquinazoline
- Purity
- 90+%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- PC400552
- Product name
- 4-Chloro-6-fluoroquinazoline
- Packaging
- 1g
- Price
- $276
- Updated
- 2021/12/16
4-CHLORO-6-FLUOROQUINAZOLINE Chemical Properties,Usage,Production
Synthesis
16499-56-2
16499-61-9
General procedure for the synthesis of 4-chloro-6-fluoroquinazoline from 6-fluoro-4-hydroxyquinazoline: a mixture of 6-fluoro-4-hydroxyquinazoline (1.64 g, 10 mmol) with phosphoryl chloride (7.5 mL, 50 mmol) and phosphorus pentachloride (6 g, 30 mmol) was heated and refluxed for 2 hours in a water bath. Upon completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into crushed ice to quench the reaction. The precipitated solid product was collected by filtration, washed well with water to remove residual acid and subsequently dried. The crude product was purified by column chromatography (eluent: hexane/ethyl acetate) to afford the target compound 4-chloro-6-fluoroquinazoline. Yield: 65%; Melting point: 140-142 °C; 1H-NMR (DMSO-d6, 300 MHz) δ 8.12 (s, 1H, ArH), 7.47 (dd, 1H, J = 7.9 Hz and 2.8 Hz, ArH), 7.53 (dd, 1H, J = 8.6 Hz and 5.1 Hz, ArH), 7.62 (s, 1H, ArH ); molecular formula: C8H4ClFN2 (molecular weight: 182); MS (ESI) m/z 183 [M + 1]+.
References
[1] Molecules, 2017, vol. 22, # 2,
[2] Patent: US5955464, 1999, A
[3] Organic Letters, 2010, vol. 12, # 3, p. 552 - 555
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 21, p. 4885 - 4888
[5] Bioorganic Chemistry, 2018, vol. 80, p. 433 - 443
4-CHLORO-6-FLUOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-CHLORO-6-FLUOROQUINAZOLINE manufacturers
- Product
- 4-CHLORO-6-FLUOROQUINAZOLINE 16499-61-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23