1,3-Dimethoxy-2-propanol
- Product Name
- 1,3-Dimethoxy-2-propanol
- CAS No.
- 623-69-8
- Chemical Name
- 1,3-Dimethoxy-2-propanol
- Synonyms
- 1,3-DiMethoxy-2-prop;3-Dimethoxy-2-propanol;glycerin dimethyl ether;1,3-dimethoxy-2-propano;1,3-Dimethoxypropan-2-ol;1,3-DIMETHOXY-2-PROPANOL;2-Propanol,1,3-dimethoxy-;glycerol,1,3-dimethylether;Glycerol α,γ-dimethyl ether;Glyceryl-1,3-dimethyl ether
- CBNumber
- CB0458401
- Molecular Formula
- C5H12O3
- Formula Weight
- 120.15
- MOL File
- 623-69-8.mol
1,3-Dimethoxy-2-propanol Property
- Boiling point:
- 169°C (estimate)
- Density
- 1.0085
- refractive index
- 1.4192
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.68±0.20(Predicted)
- form
- liquid
- color
- Colourless
- CAS DataBase Reference
- 623-69-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Propanol, 1,3-dimethoxy-(623-69-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D6094
- Product name
- 1,3-Dimethoxypropan-2-ol
- Purity
- min. 97.0 %
- Packaging
- 5G
- Price
- $39
- Updated
- 2025/07/31
- Product number
- D6094
- Product name
- 1,3-Dimethoxypropan-2-ol
- Purity
- min. 97.0 %
- Packaging
- 25G
- Price
- $116
- Updated
- 2025/07/31
- Product number
- D471325
- Product name
- 1,3-Dimethoxy-2-propanol
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 075288
- Product name
- 1,3-Dimethoxypropan-2-ol
- Purity
- 95+%
- Packaging
- 25g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- FD138811
- Product name
- 1,3-Dimethoxy-2-propanol
- Packaging
- 5G
- Price
- $110
- Updated
- 2021/12/16
1,3-Dimethoxy-2-propanol Chemical Properties,Usage,Production
Uses
1,3-Dimethoxy-2-propanol is a possbile antiknock additive for gasoline and diesel fuel. It is also used to prepare heteroarylcarbamoylbenzene derivatives as glucokinase activators.
Synthesis
67-56-1
106-89-8
623-69-8
According to an improved method described in the literature [15], 1,3-dimethoxy-2-propanol was synthesized by sodium hydroxide catalysis using methanol and 1-chloro-2,3-epoxypropane as raw materials. The procedure was as follows: 165 mL of anhydrous methanol and 11.4 g of sodium hydroxide were added to a 250 mL three-neck flask. The mixture was stirred and heated to reflux to form a homogeneous solution. 1-Chloro-2,3-epoxypropane (25.0 g) was added slowly and dropwise over a period of 1 hour. The reaction solution was kept at reflux for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with concentrated hydrochloric acid to 7. The precipitated sodium chloride was removed by filtration and the filtrate was fractionated under reduced pressure to afford 1,3-dimethoxy-2-propanol (29.8 g, 91.9% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 3.92-3.99 (m, 1H, CH), 3.40-3.49 (m, 4H, CH2), 3.39 (s, 6H, CH3), and 2.59 (s, 1H, OH, the position and intensity of this peak varied with the concentration of the sample).13C NMR (75 MHz, CDCl3): δ 73.9 (CH2), 69.1 (CH), 59.0 (CH3). ESI-HRMS: m/z [M + Na]+ Calculated value: 143.0684 (C5H12O3 + Na), measured value: 143.0684. Elemental analysis results (C5H12O3): Calculated value: C 49.98%, H 10.07%; measured value: C 49.97%, H 9.84%.
References
[1] Chinese Chemical Letters, 2013, vol. 24, # 12, p. 1106 - 1108
[2] Organic Letters, 2017, vol. 19, # 11, p. 2789 - 2792
[3] Patent: WO2011/60228, 2011, A1. Location in patent: Page/Page column 69-70
[4] Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1897, vol. <5> 6 II, p. 350
[5] Green Chemistry, 2015, vol. 17, # 8, p. 4326 - 4333
1,3-Dimethoxy-2-propanol Preparation Products And Raw materials
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View Lastest Price from 1,3-Dimethoxy-2-propanol manufacturers
- Product
- 1,3-Dimethoxy-2-propanol 623-69-8
- Price
- US $60.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-18
- Product
- 1,3-Dimethoxy-2-propanol 623-69-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21
- Product
- 1,3-Dimethoxy-2-propanol 623-69-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11