TUBERCIDIN

Product Name: TUBERCIDIN
CAS No.: 69-33-0
Chemical Name: TUBERCIDIN
Synonyms: (2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;b120121;u-10071;CS-2599;nsc56408;ski26996;TUBERCIDIN;Aids051983;7-Deaza-Ar;7-Deaza-rA
CBNumber: CB0461137
Molecular Formula: C11H14N4O4
Formula Weight: 266.25
MOL File: 69-33-0.mol

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TUBERCIDIN Property

Melting point:: 247-248 °C (decomp)(Solv: water (7732-18-5))
alpha: D17 -67° (50% acetic acid)
Boiling point:: 409.46°C (rough estimate)
Density: 1.2896 (rough estimate)
refractive index: 1.8340 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Soluble in DMSO
form: powder
pka: 12.44±0.70(Predicted)
color: off-white
Merck: 13,9875
BRN: 38498
Stability:: Hygroscopic
InChIKey: HDZZVAMISRMYHH-UIRWVKCDSA-N
CAS DataBase Reference: 69-33-0

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Safety

Hazard Codes: T+
Risk Statements: 28
Safety Statements: 36/37/39-45
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: UY8870000
F: 10
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29419090
Toxicity: LD50 i.v. in mice: 45 mg/kg (Anzai)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T0642
Product name: Tubercidin
Purity: from
Packaging: 10mg
Price: $227
Updated: 2024/03/01

Sigma-Aldrich

Product number: T0642
Product name: Tubercidin
Purity: from
Packaging: 50mg
Price: $337.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: T0642
Product name: Tubercidin
Purity: from
Packaging: 250mg
Price: $2540
Updated: 2024/03/01

TRC

Product number: T897070
Product name: TubercidinTrifluoroacetate
Packaging: 100mg
Price: $970
Updated: 2021/12/16

Usbiological

Product number: 295770
Product name: 7-Deazaadenosine
Packaging: 10mg
Price: $355
Updated: 2021/12/16

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TUBERCIDIN Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

Tubercidin is a nucleoside metabolite first isolated from Streptomyces tubericidus. Tubercidin, like other nucleosides, is a broad spectrum, potent chemotherapeutic agent active against viruses, bacteria, fungi, protozoans and tumours. Tubercidin acts at a diverse range of sites, such as RNA processing, nucleic acid and protein synthesis, and acts as a nucleoside mimic of adenosine.

Definition

ChEBI: An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.

Biological Activity

tubercidin is an adenosine analog antibiotic agent.nucleoside antibiotics are a family of natural products with various biological functions. their biosynthesis is a complex process via multistep enzymatic reactions.

in vitro

previous study showed that tubercidin alone had a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells. bfu-e were more sensitive at higher doses of tubercidin than cfu-gm. the 99% complete inhibition of bfu-e colonies was observed at 10 nm tubercidin, whereas complete inhibition of cfu-gm occurred at 100 nm [1].

in vivo

animal toxicity study showed that four successive daily injections of tubercidin at 5 mg/kg per day could produce 100% mouse mortality within 3 to 5 days, with massive peritonitis and intestinal obstruction. in addition, coadministration of nbmpr-p at 25 mg/kg per day could protect the mice from the tubercidin lethality and allow the repetition of the regimen for a second time with 100% survival [1].

IC 50

3.4 and 3.7 nm for granulocyte-macrophage cfu (cfu-gm) and erythroid burst-forming units (bfu-e), respectively

Purification Methods

7-Deazaadenosine forms needles from hot H2O. It is soluble in H2O (0.33%), MeOH (0.5%) and EtOH (0.05%). It has UV max at 270nm ( 12,100) in 0.001N NaOH. The picrate has m 229-231o(dec). [Tolman et al. J Am Chem Soc 91 2102 1969, Mizuno et al. J Org Chem 28 3329 1963, IR: Anzai et al. J Antibiot (Japan) [9] 10 201 1957, Beilstein 26 IV 1117.]

References

[1] el kouni mh,diop d,o'shea p,carlisle r,sommadossi jp. prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. antimicrob agents chemother.1989 jun;33(6):824-7.
[2] grage tb,rochlin db,weiss aj,wilson wl. clinical studies with tubercidin administered after absorption into human erythrocytes. cancer res.1970 jan;30(1):79-81.

TUBERCIDIN Preparation Products And Raw materials

Raw materials

Preparation Products

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TUBERCIDIN Suppliers

China 124 Germany 1 Japan 1 Switzerland 2 United Kingdom 3 United States 17 Global 148

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 950
Advantage: 55

Fuyang Ziyi Biological Pharmaceutical Co., Ltd.

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Country: China
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Maanshan geneyan biotech Co.,LTD

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Email: market@geneyan-bio.com
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-5842013-801 18155347026
Fax: 086-553-5843138
Email: sale@huarensh.com
Country: China
ProdList: 296
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

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Email: sales@meilune.com
Country: China
ProdList: 4647
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T&W GROUP

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Chengdu NoVi Biotechnology Co., Ltd.

Tel: 028-81458053
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Nanjing Baifuli Technology Co., Ltd.

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Zhengzhou GranLen pharmaceutical Technology Co., Ltd.

Tel: 0371-85513397
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View Lastest Price from TUBERCIDIN manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 7-Deaza-adeonsine 69-33-0
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 97%min
Supply Ability: 100kgs
Release date: 2021-09-07

Henan Aochuang Chemical Co.,Ltd.

Product: TUBERCIDIN 69-33-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Career Henan Chemical Co

Product: TUBERCIDIN 69-33-0
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-08-02

69-33-0, TUBERCIDINRelated Search:

API-2 SANGIVAMYCIN 5-IODOTUBERCIDIN 4-AMINO-5-CYANO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE tubercidin 5'-phosphate,TUBERCIDIN-5'-O-MONOPHOSPHATE SODIUM SALT,tubercidin-5-monophosphat thiosangivamycin 7-DEAZA-A CEP Triciribine TUBERCIDIN tubercidin 3',5'-cyclic phosphate ara-tubercidin tubercidin 5'-triphosphate tubercidin-5'-diphosphate ara-tubercidin 5'-triphosphate tubercidin 5'-diphosphate-5'-1,2-dipalmitin TUBERCIDIN, [5-3H] SANGIVAMYCIN, [3H]- 7-DEAZA-7-CARBAMOYLADENOSINE HYDRATE

TUBERCIDIN

TUBERCIDINE

3-d)pyrimidin-4-amine,7-beta-d-ribofuranosyl-7h-pyrrolo(

3-d)pyrimidine,4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(

4-amino-7-(beta-d-ribofuranosyl)-pyrrolo(2,3-d)pyrimidine

4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(2,3-d)pyrimidine

7-beta-d-ribofuranosyl-7h-pyrrolo(2,3-d)pyrimidine-4-amine

7-deaza-adenosin

antibiotic155b2t

antibioticxk101-1

b120121

nsc56408

7-Deazaadenosine, XK 101-1, NSC 56408, SparsoMycin A, U 10071

Sparsamycin A

N7-Deazaadenosine

(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-b-D-ribofuranosyl-

ski26996

sparsomycina

u-10071

tubercidin from streptomyces tubercidicus

tubercidin from streptomyces*tubercidicus

7-beta-CD-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

4-AMINO-7-BETA-D-RIBOFURANOSYL-7H-PYROLLO(2,3-D)PYRIMIDINE

7H-Pyrrolo2,3-dpyrimidin-4-amine, 7-.beta.-D-ribofuranosyl-

7-Deaza-D-adenosine

4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine

Sparsomycine A

7-.beta.-D-ribofuranosyl-7H-pyrrolo-[2,3-d]pyrimidin-4-amine

7-Deazadenosine

7H-Pyrrolo(2,3-D)pyrimidine, 4-amino-7-beta-D-ribofuranosyl-

Aids051983

Aids-051983

2-(4-aMinopyrrolo[2,3-d]pyriMidin-7-yl)-5-(hydroxyMethyl)oxolane-3,4-diol

7-deaza-adenosin(Tubercidine)

7-DEAZAADENOSINE

Tubercidin (7-Deazaadenosine

7-Deaza-adeonsine

CS-2599

Tubercidin, >97%

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-

7-Deazaadenosine, Tubercidin, Sparsomycine A

4-Amino-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

TUBERCIDIN USP/EP/BP

7-Deaza-Ar

7-Deaza-rA

Tubercidin (6CI)

69-33-0

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