API-2
- Product Name
- API-2
- CAS No.
- 35943-35-2
- Chemical Name
- API-2
- Synonyms
- TCN;IAP1;MIHC;MYHL;BBMI;API-2;BIRC3;RNF49;MYO1A;DFNA48
- CBNumber
- CB3270000
- Molecular Formula
- C13H16N6O4
- Formula Weight
- 320.3
- MOL File
- 35943-35-2.mol
API-2 Property
- Melting point:
- 207 °C (decomp)
- Boiling point:
- 459.21°C (rough estimate)
- Density
- 1.2633 (rough estimate)
- refractive index
- 1.7000 (estimate)
- storage temp.
- Store at RT
- solubility
- DMSO: >10mg/mL
- form
- powder
- pka
- 12.35±0.70(Predicted)
- color
- tan
- InChIKey
- HOGVTUZUJGHKPL-HTVVRFAVSA-N
Safety
- WGK Germany
- 3
- RTECS
- RY8455000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T3830
- Product name
- Triciribine hydrate
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 124038
- Product name
- InSolution? Akt Inhibitor V, Triciribine
- Packaging
- 2mg
- Price
- $345
- Updated
- 2024/03/01
- Product number
- SAB1303874
- Product name
- ANTI-MYO1A (CENTER S291) antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400μL
- Price
- $461
- Updated
- 2023/01/07
- Product number
- 10010237
- Product name
- Triciribine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 10010237
- Product name
- Triciribine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
API-2 Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
Uses
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
Uses
Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.
Definition
ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor.
Biological Activity
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Biochem/physiol Actions
Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.
storage
Store at RT
API-2 Preparation Products And Raw materials
Raw materials
Preparation Products
API-2 Suppliers
- Tel
- 27-27-84888682 18086046872
- Fax
- 027-84888682
- hhdpharm@hotmail.com
- Country
- China
- ProdList
- 117
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94838
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 0510-83588313-802 18800520310;
- sales@chemshuttle.com
- Country
- China
- ProdList
- 3062
- Advantage
- 62
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4647
- Advantage
- 58
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1494
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 400-6206333 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
View Lastest Price from API-2 manufacturers
- Product
- API-2 35943-35-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-04-14
- Product
- API-2 / TRICIRIBINE 35943-35-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2023-08-07
- Product
- Triciribine hydrate;TCN 35943-35-2
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 98%+
- Supply Ability
- 100kgs
- Release date
- 2021-05-27